ID 1XOMA STANDARD; PRT; 349 AA. DT CONVERTED FROM PDB (SEQRES) 1XOM DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.550 CC R-Factor 0.184 FT #SUB 154 218 GLU A 175 239 LYS B Protein S 3 FT #SUB 156 220 ALA A 197 261 ARG B Protein B 1 FT #SUB 157 221 LEU A 171 235 ALA B Protein B 2 FT #SUB 157 221 LEU A 174 238 PHE B Protein S 1 FT #SUB 157 221 LEU A 175 239 LYS B Protein S 4 FT #SUB 158 222 MET A 158 222 MET B Protein S 5 FT #SUB 158 222 MET A 159 223 TYR B Protein A 6 FT #SUB 158 222 MET A 171 235 ALA B Protein B 1 FT #SUB 159 223 TYR A 158 222 MET B Protein S 6 FT #SUB 159 223 TYR A 159 223 TYR B Protein S 4 FT #SUB 160 224 ASN A 167 231 ASN B Protein S 7 FT #SUB 160 224 ASN A 170 234 LEU B Protein S 6 FT #SUB 160 224 ASN A 171 235 ALA B Protein S 1 FT #SUB 160 224 ASN A 197 261 ARG B Protein B 1 FT #SUB 160 224 ASN A 201 265 ILE B Protein A 2 FT #SUB 161 225 ASP A 197 261 ARG B Protein A 11 FT #SUB 167 231 ASN A 160 224 ASN B Protein A 6 FT #SUB 170 234 LEU A 160 224 ASN B Protein A 6 FT #SUB 171 235 ALA A 157 221 LEU B Protein A 2 FT #SUB 171 235 ALA A 158 222 MET B Protein S 1 FT #SUB 171 235 ALA A 160 224 ASN B Protein B 1 FT #SUB 175 239 LYS A 158 222 MET B Protein S 1 FT #SUB 178 242 GLN A 157 221 LEU B Protein S 1 FT #SUB 197 261 ARG A 156 220 ALA B Protein S 2 FT #SUB 197 261 ARG A 160 224 ASN B Protein S 1 FT #SUB 197 261 ARG A 161 225 ASP B Protein S 11 FT #SUB 201 265 ILE A 160 224 ASN B Protein S 3 FT #HET 51 115 ASN A 9 715 EDO A S 8 FT #HET 86 150 GLU A 7 707 EDO A A 6 FT #HET 87 151 ASP A 7 707 EDO A B 3 FT #HET 89 153 TYR A 7 707 EDO A A 5 FT #HET 91 155 ALA A 7 707 EDO A A 2 FT #HET 91 155 ALA A 9 715 EDO A A 5 FT #HET 95 159 TYR A 3 603 CIO A S 4 FT #HET 96 160 HIS A 3 603 CIO A S 3 FT #HET 97 161 ASN A 9 715 EDO A S 3 FT #HET 98 162 ASN A 7 707 EDO A S 5 FT #HET 98 162 ASN A 9 715 EDO A S 5 FT #HET 99 163 ILE A 9 715 EDO A S 4 FT #HET 100 164 HIS A 1 1001 ZN A S 3 FT #HET 111 175 LEU A 10 716 EDO A S 1 FT #HET 114 178 THR A 10 716 EDO A S 5 FT #HET 115 179 PRO A 8 712 EDO A S 2 FT #HET 116 180 ALA A 8 712 EDO A A 3 FT #HET 119 183 ALA A 11 719 EDO A B 4 FT #HET 120 184 VAL A 11 719 EDO A B 3 FT #HET 122 186 THR A 5 703 EDO A S 2 FT #HET 125 189 GLU A 5 703 EDO A S 1 FT #HET 136 200 HIS A 1 1001 ZN A S 3 FT #HET 137 201 ASP A 1 1001 ZN A S 3 FT #HET 137 201 ASP A 2 1002 MG A S 3 FT #HET 145 209 ASN A 6 704 EDO A S 3 FT #HET 146 210 GLN A 6 704 EDO A A 2 FT #HET 149 213 ILE A 6 704 EDO A S 1 FT #HET 174 238 PHE A 12 720 EDO A S 4 FT #HET 185 249 PHE A 12 720 EDO A S 3 FT #HET 193 257 ARG A 12 720 EDO A A 10 FT #HET 197 261 ARG A 12 720 EDO A S 2 FT #HET 198 262 LYS A 4 702 EDO A A 6 FT #HET 201 265 ILE A 4 702 EDO A S 2 FT #HET 202 266 ASP A 4 702 EDO A S 4 FT #HET 207 271 THR A 3 603 CIO A B 1 FT #HET 209 273 MET A 3 603 CIO A S 9 FT #HET 231 295 SER A 8 712 EDO A B 2 FT #HET 232 296 GLY A 8 712 EDO A B 2 FT #HET 242 306 ARG A 5 703 EDO A S 5 FT #HET 254 318 ASP A 1 1001 ZN A S 3 FT #HET 254 318 ASP A 3 603 CIO A S 1 FT #HET 255 319 LEU A 3 603 CIO A S 3 FT #HET 257 321 ASN A 3 603 CIO A S 4 FT #HET 268 332 TRP A 3 603 CIO A B 2 FT #HET 269 333 THR A 3 603 CIO A A 6 FT #HET 272 336 ILE A 3 603 CIO A S 7 FT #HET 273 337 MET A 3 603 CIO A S 4 FT #HET 276 340 PHE A 3 603 CIO A S 11 FT #HET 293 357 MET A 3 603 CIO A S 6 FT #HET 304 368 SER A 3 603 CIO A A 4 FT #HET 305 369 GLN A 3 603 CIO A S 18 FT #HET 308 372 PHE A 3 603 CIO A S 37 FT #HET 320 384 TRP A 10 716 EDO A S 2 FT #HET 324 388 VAL A 10 716 EDO A S 2 FT #HET 325 389 HIS A 8 712 EDO A B 3 FT #HET 326 390 PRO A 8 712 EDO A S 1 FT #HET 327 391 ASP A 8 712 EDO A S 8 FT #HET 327 391 ASP A 10 716 EDO A A 5 FT #HET 328 392 ALA A 10 716 EDO A A 5 FT #HET 331 395 ILE A 10 716 EDO A S 2 FT DISORDER 1 21 FT DISORDER 348 349 CC SEQUENCE 326 AA (ATOM); CC TEQEDVLAKE LEDVNKWGLH VFRIAELSGN RPLTVIMHTI FQERDLLKTF KIPVDTLITY CC LMTLEDHYHA DVAYHNNIHA ADVVQSTHVL LSTPALEAVF TDLEILAAIF ASAIHDVDHP CC GVSNQFLINT NSELALMYND SSVLENHHLA VGFKLLQEEN CDIFQNLTKK QRQSLRKMVI CC DIVLATDMSK HMNLLADLKT MVETKKVTSS GVLLLDNYSD RIQVLQNMVH CADLSNPTKP CC LQLYRQWTDR IMEEFFRQGD RERERGMEIS PMCDKHNASV EKSQVGFIDY IVHPLWETWA CC DLVHPDAQDI LDTLEDNREW YQSTIP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MGSSHHHHHHSSGLVPRGSHMTEQEDVLAKELEDVNKWGLHVFRIAELSG CC ATOM ---------------------TEQEDVLAKELEDVNKWGLHVFRIAELSG CC ***************************** CC SEQRES NRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIH CC ATOM NRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIH CC ************************************************** CC SEQRES AADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN CC ATOM AADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN CC ************************************************** CC SEQRES TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMV CC ATOM TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMV CC ************************************************** CC SEQRES IDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV CC ATOM IDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV CC ************************************************** CC SEQRES HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS CC ATOM HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS CC ************************************************** CC SEQRES VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQS CC ATOM VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP-- CC *********************************************** SQ SEQUENCE 349 AA; MW; CN; MGSSHHHHHH SSGLVPRGSH MTEQEDVLAK ELEDVNKWGL HVFRIAELSG NRPLTVIMHT IFQERDLLKT FKIPVDTLIT YLMTLEDHYH ADVAYHNNIH AADVVQSTHV LLSTPALEAV FTDLEILAAI FASAIHDVDH PGVSNQFLIN TNSELALMYN DSSVLENHHL AVGFKLLQEE NCDIFQNLTK KQRQSLRKMV IDIVLATDMS KHMNLLADLK TMVETKKVTS SGVLLLDNYS DRIQVLQNMV HCADLSNPTK PLQLYRQWTD RIMEEFFRQG DRERERGMEI SPMCDKHNAS VEKSQVGFID YIVHPLWETW ADLVHPDAQD ILDTLEDNRE WYQSTIPQS // ID 1XOMB STANDARD; PRT; 349 AA. DT CONVERTED FROM PDB (SEQRES) 1XOM DE cAMP-specific 3',5'-cyclic phosphodiesterase 4D OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 1.550 CC R-Factor 0.184 FT #SUB 156 220 ALA B 197 261 ARG A Protein B 2 FT #SUB 157 221 LEU B 171 235 ALA A Protein B 2 FT #SUB 157 221 LEU B 178 242 GLN A Protein S 1 FT #SUB 158 222 MET B 158 222 MET A Protein S 5 FT #SUB 158 222 MET B 159 223 TYR A Protein A 6 FT #SUB 158 222 MET B 171 235 ALA A Protein B 1 FT #SUB 158 222 MET B 175 239 LYS A Protein S 1 FT #SUB 159 223 TYR B 158 222 MET A Protein S 6 FT #SUB 159 223 TYR B 159 223 TYR A Protein S 4 FT #SUB 160 224 ASN B 167 231 ASN A Protein S 6 FT #SUB 160 224 ASN B 170 234 LEU A Protein S 6 FT #SUB 160 224 ASN B 171 235 ALA A Protein S 1 FT #SUB 160 224 ASN B 197 261 ARG A Protein B 1 FT #SUB 160 224 ASN B 201 265 ILE A Protein A 3 FT #SUB 161 225 ASP B 197 261 ARG A Protein A 11 FT #SUB 167 231 ASN B 160 224 ASN A Protein A 7 FT #SUB 170 234 LEU B 160 224 ASN A Protein A 6 FT #SUB 171 235 ALA B 157 221 LEU A Protein A 2 FT #SUB 171 235 ALA B 158 222 MET A Protein S 1 FT #SUB 171 235 ALA B 160 224 ASN A Protein B 1 FT #SUB 174 238 PHE B 157 221 LEU A Protein S 1 FT #SUB 175 239 LYS B 154 218 GLU A Protein S 3 FT #SUB 175 239 LYS B 157 221 LEU A Protein A 4 FT #SUB 197 261 ARG B 156 220 ALA A Protein S 1 FT #SUB 197 261 ARG B 160 224 ASN A Protein S 1 FT #SUB 197 261 ARG B 161 225 ASP A Protein S 11 FT #SUB 201 265 ILE B 160 224 ASN A Protein S 2 FT #HET 28 92 LEU B 20 710 EDO B S 2 FT #HET 49 113 SER B 20 710 EDO B A 6 FT #HET 56 120 VAL B 20 710 EDO B S 2 FT #HET 95 159 TYR B 15 601 CIO B S 5 FT #HET 96 160 HIS B 15 601 CIO B S 4 FT #HET 100 164 HIS B 13 2001 ZN B S 3 FT #HET 136 200 HIS B 13 2001 ZN B S 3 FT #HET 137 201 ASP B 13 2001 ZN B S 3 FT #HET 137 201 ASP B 14 2002 MG B S 3 FT #HET 144 208 SER B 21 711 EDO B S 7 FT #HET 160 224 ASN B 4 702 EDO A B 1 FT #HET 162 226 SER B 4 702 EDO A S 1 FT #HET 171 235 ALA B 26 721 EDO B B 1 FT #HET 172 236 VAL B 26 721 EDO B S 1 FT #HET 174 238 PHE B 24 717 EDO B S 5 FT #HET 175 239 LYS B 26 721 EDO B S 1 FT #HET 177 241 LEU B 24 717 EDO B S 1 FT #HET 185 249 PHE B 24 717 EDO B S 2 FT #HET 191 255 LYS B 19 709 EDO B B 1 FT #HET 193 257 ARG B 24 717 EDO B A 4 FT #HET 193 257 ARG B 25 718 EDO B A 9 FT #HET 194 258 GLN B 19 709 EDO B S 7 FT #HET 194 258 GLN B 25 718 EDO B A 5 FT #HET 195 259 SER B 19 709 EDO B A 6 FT #HET 196 260 LEU B 24 717 EDO B S 2 FT #HET 197 261 ARG B 24 717 EDO B S 3 FT #HET 197 261 ARG B 25 718 EDO B S 3 FT #HET 198 262 LYS B 19 709 EDO B S 1 FT #HET 207 271 THR B 15 601 CIO B B 1 FT #HET 209 273 MET B 15 601 CIO B S 8 FT #HET 254 318 ASP B 13 2001 ZN B S 3 FT #HET 255 319 LEU B 15 601 CIO B S 2 FT #HET 257 321 ASN B 15 601 CIO B S 4 FT #HET 261 325 PRO B 17 705 EDO B A 2 FT #HET 263 327 GLN B 18 706 EDO B S 1 FT #HET 266 330 ARG B 16 701 EDO B S 1 FT #HET 266 330 ARG B 22 713 EDO B A 13 FT #HET 268 332 TRP B 15 601 CIO B B 2 FT #HET 269 333 THR B 15 601 CIO B A 6 FT #HET 269 333 THR B 22 713 EDO B S 2 FT #HET 270 334 ASP B 22 713 EDO B S 5 FT #HET 272 336 ILE B 15 601 CIO B S 11 FT #HET 273 337 MET B 15 601 CIO B S 4 FT #HET 276 340 PHE B 15 601 CIO B S 11 FT #HET 276 340 PHE B 21 711 EDO B S 3 FT #HET 279 343 GLN B 21 711 EDO B S 5 FT #HET 291 355 SER B 21 711 EDO B S 3 FT #HET 293 357 MET B 15 601 CIO B S 5 FT #HET 301 365 VAL B 22 713 EDO B S 1 FT #HET 302 366 GLU B 16 701 EDO B S 7 FT #HET 304 368 SER B 15 601 CIO B A 4 FT #HET 305 369 GLN B 15 601 CIO B S 17 FT #HET 308 372 PHE B 15 601 CIO B S 34 FT #HET 334 398 THR B 17 705 EDO B S 1 FT #HET 337 401 ASP B 23 714 EDO B A 4 FT #HET 338 402 ASN B 23 714 EDO B A 6 FT #HET 341 405 TRP B 16 701 EDO B S 3 FT #HET 342 406 TYR B 16 701 EDO B S 2 FT #HET 342 406 TYR B 22 713 EDO B S 7 FT DISORDER 1 23 FT DISORDER 230 232 FT DISORDER 348 349 CC SEQUENCE 321 AA (ATOM); CC QEDVLAKELE DVNKWGLHVF RIAELSGNRP LTVIMHTIFQ ERDLLKTFKI PVDTLITYLM CC TLEDHYHADV AYHNNIHAAD VVQSTHVLLS TPALEAVFTD LEILAAIFAS AIHDVDHPGV CC SNQFLINTNS ELALMYNDSS VLENHHLAVG FKLLQEENCD IFQNLTKKQR QSLRKMVIDI CC VLATDMSKHM NLLADLKTMV ETKKVTVLLL DNYSDRIQVL QNMVHCADLS NPTKPLQLYR CC QWTDRIMEEF FRQGDRERER GMEISPMCDK HNASVEKSQV GFIDYIVHPL WETWADLVHP CC DAQDILDTLE DNREWYQSTI P CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MGSSHHHHHHSSGLVPRGSHMTEQEDVLAKELEDVNKWGLHVFRIAELSG CC ATOM -----------------------QEDVLAKELEDVNKWGLHVFRIAELSG CC *************************** CC SEQRES NRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIH CC ATOM NRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIH CC ************************************************** CC SEQRES AADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN CC ATOM AADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLIN CC ************************************************** CC SEQRES TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMV CC ATOM TNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMV CC ************************************************** CC SEQRES IDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV CC ATOM IDIVLATDMSKHMNLLADLKTMVETKKVT---VLLLDNYSDRIQVLQNMV CC ***************************** ****************** CC SEQRES HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS CC ATOM HCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNAS CC ************************************************** CC SEQRES VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQS CC ATOM VEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP-- CC *********************************************** SQ SEQUENCE 349 AA; MW; CN; MGSSHHHHHH SSGLVPRGSH MTEQEDVLAK ELEDVNKWGL HVFRIAELSG NRPLTVIMHT IFQERDLLKT FKIPVDTLIT YLMTLEDHYH ADVAYHNNIH AADVVQSTHV LLSTPALEAV FTDLEILAAI FASAIHDVDH PGVSNQFLIN TNSELALMYN DSSVLENHHL AVGFKLLQEE NCDIFQNLTK KQRQSLRKMV IDIVLATDMS KHMNLLADLK TMVETKKVTS SGVLLLDNYS DRIQVLQNMV HCADLSNPTK PLQLYRQWTD RIMEEFFRQG DRERERGMEI SPMCDKHNAS VEKSQVGFID YIVHPLWETW ADLVHPDAQD ILDTLEDNRE WYQSTIPQS //