ID 1T5AA STANDARD; PRT; 567 AA. DT CONVERTED FROM PDB (SEQRES) 1T5A DE Pyruvate kinase, M2 isozyme OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.800 CC R-Factor 0.231 FT #SUB 60 24 ASP A 436 400 ARG B Protein S 1 FT #SUB 428 392 LEU A 436 400 ARG B Protein S 7 FT #SUB 432 396 GLU A 432 396 GLU B Protein S 9 FT #SUB 432 396 GLU A 435 399 ARG B Protein S 1 FT #SUB 435 399 ARG A 432 396 GLU B Protein S 1 FT #SUB 435 399 ARG A 435 399 ARG B Protein S 5 FT #SUB 435 399 ARG A 454 418 GLU B Protein S 8 FT #SUB 436 400 ARG A 60 24 ASP B Protein S 1 FT #SUB 436 400 ARG A 428 392 LEU B Protein S 5 FT #SUB 438 402 ALA A 458 422 LYS B Protein S 1 FT #SUB 439 403 PRO A 458 422 LYS B Protein B 1 FT #SUB 440 404 ILE A 58 22 MET B Protein S 1 FT #SUB 441 405 THR A 458 422 LYS B Protein A 4 FT #SUB 441 405 THR A 459 423 CYS B Protein B 1 FT #SUB 444 408 PRO A 563 527 VAL B Protein A 3 FT #SUB 446 410 GLU A 458 422 LYS B Protein S 1 FT #SUB 447 411 ALA A 455 419 ALA B Protein A 3 FT #SUB 447 411 ALA A 458 422 LYS B Protein A 4 FT #SUB 448 412 THR A 563 527 VAL B Protein S 2 FT #SUB 450 414 VAL A 454 418 GLU B Protein A 4 FT #SUB 451 415 GLY A 451 415 GLY B Protein B 2 FT #SUB 454 418 GLU A 435 399 ARG B Protein S 11 FT #SUB 454 418 GLU A 450 414 VAL B Protein S 3 FT #SUB 454 418 GLU A 454 418 GLU B Protein S 4 FT #SUB 455 419 ALA A 447 411 ALA B Protein A 3 FT #SUB 458 422 LYS A 438 402 ALA B Protein S 1 FT #SUB 458 422 LYS A 439 403 PRO B Protein S 1 FT #SUB 458 422 LYS A 441 405 THR B Protein A 3 FT #SUB 458 422 LYS A 446 410 GLU B Protein S 1 FT #SUB 458 422 LYS A 447 411 ALA B Protein S 1 FT #SUB 458 422 LYS A 450 414 VAL B Protein S 2 FT #SUB 458 422 LYS A 480 444 TYR B Protein S 2 FT #SUB 459 423 CYS A 441 405 THR B Protein A 2 FT #SUB 480 444 TYR A 458 422 LYS B Protein S 2 FT #SUB 559 523 ASN A 561 525 MET B Protein B 1 FT #SUB 559 523 ASN A 562 526 ARG B Protein A 4 FT #SUB 559 523 ASN A 563 527 VAL B Protein A 6 FT #SUB 560 524 THR A 561 525 MET B Protein B 2 FT #SUB 560 524 THR A 562 526 ARG B Protein S 3 FT #SUB 561 525 MET A 559 523 ASN B Protein B 1 FT #SUB 561 525 MET A 560 524 THR B Protein B 2 FT #SUB 561 525 MET A 561 525 MET B Protein A 10 FT #SUB 562 526 ARG A 559 523 ASN B Protein A 5 FT #SUB 562 526 ARG A 560 524 THR B Protein S 4 FT #SUB 563 527 VAL A 444 408 PRO B Protein S 4 FT #SUB 563 527 VAL A 448 412 THR B Protein S 2 FT #SUB 563 527 VAL A 559 523 ASN B Protein B 6 FT #SUB 53 17 GLN A 344 308 LEU C Protein S 1 FT #SUB 61 25 THR A 433 397 GLU C Protein A 12 FT #SUB 62 26 PHE A 62 26 PHE C Protein S 1 FT #SUB 62 26 PHE A 429 393 GLN C Protein S 1 FT #SUB 62 26 PHE A 433 397 GLU C Protein A 9 FT #SUB 63 27 LEU A 351 315 GLY C Protein S 2 FT #SUB 63 27 LEU A 433 397 GLU C Protein A 4 FT #SUB 63 27 LEU A 434 398 LEU C Protein S 1 FT #SUB 63 27 LEU A 437 401 LEU C Protein S 2 FT #SUB 64 28 GLU A 355 319 ARG C Protein S 2 FT #SUB 64 28 GLU A 437 401 LEU C Protein S 1 FT #SUB 66 30 MET A 347 311 LYS C Protein A 2 FT #SUB 66 30 MET A 348 312 MET C Protein B 3 FT #SUB 67 31 CYS A 348 312 MET C Protein B 1 FT #SUB 67 31 CYS A 351 315 GLY C Protein S 2 FT #SUB 67 31 CYS A 352 316 ARG C Protein A 11 FT #SUB 67 31 CYS A 355 319 ARG C Protein S 4 FT #SUB 69 33 LEU A 344 308 LEU C Protein S 1 FT #SUB 69 33 LEU A 347 311 LYS C Protein S 1 FT #SUB 69 33 LEU A 348 312 MET C Protein B 2 FT #SUB 71 35 ILE A 310 274 HIS C Protein S 2 FT #SUB 71 35 ILE A 313 277 VAL C Protein S 1 FT #SUB 71 35 ILE A 337 301 ILE C Protein S 2 FT #SUB 71 35 ILE A 341 305 LYS C Protein A 4 FT #SUB 71 35 ILE A 344 308 LEU C Protein S 1 FT #SUB 71 35 ILE A 345 309 ALA C Protein S 2 FT #SUB 72 36 ASP A 310 274 HIS C Protein S 4 FT #SUB 72 36 ASP A 314 278 ARG C Protein S 1 FT #SUB 214 178 ASP A 378 342 ARG C Protein S 1 FT #SUB 215 179 GLY A 375 339 ARG C Protein B 1 FT #SUB 216 180 LEU A 373 337 LYS C Protein S 1 FT #SUB 310 274 HIS A 71 35 ILE C Protein S 2 FT #SUB 310 274 HIS A 72 36 ASP C Protein S 4 FT #SUB 313 277 VAL A 71 35 ILE C Protein S 1 FT #SUB 330 294 ARG A 378 342 ARG C Protein A 9 FT #SUB 330 294 ARG A 382 346 SER C Protein S 1 FT #SUB 331 295 GLY A 378 342 ARG C Protein B 4 FT #SUB 334 298 GLY A 378 342 ARG C Protein B 7 FT #SUB 335 299 ILE A 378 342 ARG C Protein S 2 FT #SUB 340 304 GLU A 413 377 MET C Protein S 1 FT #SUB 340 304 GLU A 416 380 LEU C Protein S 3 FT #SUB 340 304 GLU A 417 381 ILE C Protein S 1 FT #SUB 340 304 GLU A 420 384 GLU C Protein B 2 FT #SUB 341 305 LYS A 71 35 ILE C Protein A 4 FT #SUB 341 305 LYS A 420 384 GLU C Protein S 6 FT #SUB 343 307 PHE A 385 349 ALA C Protein S 6 FT #SUB 343 307 PHE A 420 384 GLU C Protein S 2 FT #SUB 343 307 PHE A 421 385 ALA C Protein S 3 FT #SUB 344 308 LEU A 71 35 ILE C Protein S 1 FT #SUB 344 308 LEU A 420 384 GLU C Protein S 1 FT #SUB 344 308 LEU A 424 388 ALA C Protein S 1 FT #SUB 345 309 ALA A 71 35 ILE C Protein B 1 FT #SUB 347 311 LYS A 69 33 LEU C Protein S 1 FT #SUB 347 311 LYS A 386 350 ASN C Protein S 2 FT #SUB 347 311 LYS A 389 353 LEU C Protein S 1 FT #SUB 348 312 MET A 66 30 MET C Protein A 3 FT #SUB 348 312 MET A 67 31 CYS C Protein S 1 FT #SUB 348 312 MET A 69 33 LEU C Protein S 2 FT #SUB 351 315 GLY A 63 27 LEU C Protein B 1 FT #SUB 351 315 GLY A 67 31 CYS C Protein B 2 FT #SUB 352 316 ARG A 67 31 CYS C Protein A 8 FT #SUB 355 319 ARG A 67 31 CYS C Protein S 5 FT #SUB 365 329 GLN A 377 341 THR C Protein S 4 FT #SUB 365 329 GLN A 378 342 ARG C Protein S 4 FT #SUB 365 329 GLN A 379 343 ALA C Protein B 1 FT #SUB 373 337 LYS A 216 180 LEU C Protein S 1 FT #SUB 375 339 ARG A 215 179 GLY C Protein S 1 FT #SUB 377 341 THR A 365 329 GLN C Protein A 4 FT #SUB 378 342 ARG A 214 178 ASP C Protein S 1 FT #SUB 378 342 ARG A 330 294 ARG C Protein S 8 FT #SUB 378 342 ARG A 331 295 GLY C Protein S 6 FT #SUB 378 342 ARG A 334 298 GLY C Protein S 5 FT #SUB 378 342 ARG A 335 299 ILE C Protein S 2 FT #SUB 378 342 ARG A 365 329 GLN C Protein A 8 FT #SUB 379 343 ALA A 365 329 GLN C Protein S 1 FT #SUB 379 343 ALA A 379 343 ALA C Protein B 1 FT #SUB 379 343 ALA A 383 347 ASP C Protein A 5 FT #SUB 382 346 SER A 330 294 ARG C Protein S 2 FT #SUB 382 346 SER A 383 347 ASP C Protein S 3 FT #SUB 383 347 ASP A 379 343 ALA C Protein S 7 FT #SUB 383 347 ASP A 382 346 SER C Protein S 3 FT #SUB 385 349 ALA A 343 307 PHE C Protein S 6 FT #SUB 386 350 ASN A 347 311 LYS C Protein S 2 FT #SUB 386 350 ASN A 386 350 ASN C Protein S 11 FT #SUB 389 353 LEU A 347 311 LYS C Protein S 1 FT #SUB 416 380 LEU A 340 304 GLU C Protein A 4 FT #SUB 417 381 ILE A 340 304 GLU C Protein A 4 FT #SUB 420 384 GLU A 340 304 GLU C Protein S 3 FT #SUB 420 384 GLU A 341 305 LYS C Protein S 7 FT #SUB 420 384 GLU A 343 307 PHE C Protein A 3 FT #SUB 420 384 GLU A 344 308 LEU C Protein S 1 FT #SUB 421 385 ALA A 343 307 PHE C Protein A 3 FT #SUB 424 388 ALA A 344 308 LEU C Protein S 1 FT #SUB 429 393 GLN A 62 26 PHE C Protein S 2 FT #SUB 429 393 GLN A 429 393 GLN C Protein S 5 FT #SUB 433 397 GLU A 61 25 THR C Protein S 10 FT #SUB 433 397 GLU A 62 26 PHE C Protein S 9 FT #SUB 433 397 GLU A 63 27 LEU C Protein S 4 FT #SUB 434 398 LEU A 63 27 LEU C Protein S 1 FT #SUB 437 401 LEU A 63 27 LEU C Protein S 3 FT #SUB 437 401 LEU A 64 28 GLU C Protein S 1 FT #SUB 60 24 ASP A 60 24 ASP D Protein S 12 FT #HET 79 43 ARG A 9 705 GOL A S 1 FT #HET 102 66 LYS A 9 705 GOL A B 3 FT #HET 103 67 SER A 9 705 GOL A B 1 FT #HET 104 68 GLY A 9 705 GOL A B 1 FT #HET 111 75 ASN A 3 534 PO4 A S 1 FT #HET 111 75 ASN A 5 701 K A S 1 FT #HET 113 77 SER A 3 534 PO4 A S 1 FT #HET 113 77 SER A 5 701 K A S 2 FT #HET 114 78 HIS A 3 534 PO4 A S 4 FT #HET 114 78 HIS A 6 702 GOL A S 3 FT #HET 115 79 GLY A 6 702 GOL A B 2 FT #HET 142 106 ARG A 9 705 GOL A S 3 FT #HET 149 113 ASP A 5 701 K A S 1 FT #HET 150 114 THR A 5 701 K A B 1 FT #HET 153 117 PRO A 8 704 GOL A B 3 FT #HET 154 118 GLU A 8 704 GOL A B 1 FT #HET 155 119 ILE A 8 704 GOL A B 1 FT #HET 156 120 ARG A 3 534 PO4 A S 6 FT #HET 242 206 LYS A 6 702 GOL A S 3 FT #HET 252 216 VAL A 8 704 GOL A S 6 FT #HET 279 243 SER A 5 701 K A S 1 FT #HET 280 244 PHE A 8 704 GOL A S 4 FT #HET 306 270 LYS A 2 533 OXL A S 2 FT #HET 306 270 LYS A 5 701 K A S 1 FT #HET 308 272 GLU A 2 533 OXL A S 5 FT #HET 308 272 GLU A 4 601 MG A S 2 FT #HET 321 285 GLU A 10 706 GOL A A 3 FT #HET 323 287 SER A 10 706 GOL A B 1 FT #HET 324 288 ASP A 10 706 GOL A S 2 FT #HET 329 293 ALA A 2 533 OXL A A 8 FT #HET 330 294 ARG A 2 533 OXL A B 2 FT #HET 331 295 GLY A 2 533 OXL A B 3 FT #HET 332 296 ASP A 2 533 OXL A A 5 FT #HET 332 296 ASP A 4 601 MG A S 2 FT #HET 336 300 GLU A 8 704 GOL A S 3 FT #HET 358 322 LYS A 10 706 GOL A S 6 FT #HET 364 328 THR A 2 533 OXL A S 6 FT #HET 396 360 MET A 2 533 OXL A S 1 FT #HET 415 379 ASN A 9 705 GOL A S 3 FT #HET 467 431 LEU A 1 532 FBP A A 5 FT #HET 468 432 THR A 1 532 FBP A A 8 FT #HET 469 433 LYS A 1 532 FBP A A 14 FT #HET 470 434 SER A 1 532 FBP A A 5 FT #HET 473 437 SER A 1 532 FBP A A 8 FT #HET 518 482 TRP A 1 532 FBP A S 8 FT #HET 518 482 TRP A 7 703 GOL A S 2 FT #HET 519 483 ALA A 7 703 GOL A B 1 FT #HET 523 487 ASP A 7 703 GOL A S 1 FT #HET 525 489 ARG A 1 532 FBP A S 9 FT #HET 549 513 THR A 7 703 GOL A S 4 FT #HET 550 514 GLY A 1 532 FBP A B 5 FT #HET 550 514 GLY A 7 703 GOL A B 4 FT #HET 552 516 ARG A 1 532 FBP A B 3 FT #HET 553 517 PRO A 1 532 FBP A A 5 FT #HET 554 518 GLY A 1 532 FBP A B 9 FT #HET 555 519 SER A 1 532 FBP A A 11 FT #HET 556 520 GLY A 1 532 FBP A B 4 FT #HET 557 521 PHE A 1 532 FBP A A 4 FT #HET 558 522 THR A 1 532 FBP A A 3 FT DISORDER 1 48 CC SEQUENCE 519 AA (ATOM); CC IQTQQLHAAM ADTFLEHMCR LDIDSPPITA RNTGIICTIG PASRSVETLK EMIKSGMNVA CC RLNFSHGTHE YHAETIKNVR TATESFASDP ILYRPVAVAL DTKGPEIRTG LIKGSGTAEV CC ELKKGATLKI TLDNAYMEKC DENILWLDYK NICKVVEVGS KIYVDDGLIS LQVKQKGADF CC LVTEVENGGS LGSKKGVNLP GAAVDLPAVS EKDIQDLKFG VEQDVDMVFA SFIRKASDVH CC EVRKVLGEKG KNIKIISKIE NHEGVRRFDE ILEASDGIMV ARGDLGIEIP AEKVFLAQKM CC MIGRCNRAGK PVICATQMLE SMIKKPRPTR AEGSDVANAV LDGADCIMLS GETAKGDYPL CC EAVRMQNLIA REAEAAIYHL QLFEELRRLA PITSDPTEAT AVGAVEASFK CCSGAIIVLT CC KSGRSAHQVA RYRPRAPIIA VTRNPQTARQ AHLYRGIFPV LCKDPVQEAW AEDVDLRVNF CC AMNVGKARGF FKKGDVVIVL TGWRPGSGFT NTMRVVPVP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDHPFTMSKPHSEAGTAFIQ CC ATOM ------------------------------------------------IQ CC ** CC SEQRES TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEM CC ATOM TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEM CC ************************************************** CC SEQRES IKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDT CC ATOM IKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDT CC ************************************************** CC SEQRES KGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI CC ATOM KGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI CC ************************************************** CC SEQRES CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGA CC ATOM CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGA CC ************************************************** CC SEQRES AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN CC ATOM AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN CC ************************************************** CC SEQRES IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI CC ATOM IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI CC ************************************************** CC SEQRES GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE CC ATOM GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE CC ************************************************** CC SEQRES TAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV CC ATOM TAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV CC ************************************************** CC SEQRES GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAH CC ATOM GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAH CC ************************************************** CC SEQRES LYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG CC ATOM LYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG CC ************************************************** CC SEQRES WRPGSGFTNTMRVVPVP CC ATOM WRPGSGFTNTMRVVPVP CC ***************** SQ SEQUENCE 567 AA; MW; CN; MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDHPFTMSKP HSEAGTAFIQ TQQLHAAMAD TFLEHMCRLD IDSPPITARN TGIICTIGPA SRSVETLKEM IKSGMNVARL NFSHGTHEYH AETIKNVRTA TESFASDPIL YRPVAVALDT KGPEIRTGLI KGSGTAEVEL KKGATLKITL DNAYMEKCDE NILWLDYKNI CKVVEVGSKI YVDDGLISLQ VKQKGADFLV TEVENGGSLG SKKGVNLPGA AVDLPAVSEK DIQDLKFGVE QDVDMVFASF IRKASDVHEV RKVLGEKGKN IKIISKIENH EGVRRFDEIL EASDGIMVAR GDLGIEIPAE KVFLAQKMMI GRCNRAGKPV ICATQMLESM IKKPRPTRAE GSDVANAVLD GADCIMLSGE TAKGDYPLEA VRMQNLIARE AEAAIYHLQL FEELRRLAPI TSDPTEATAV GAVEASFKCC SGAIIVLTKS GRSAHQVARY RPRAPIIAVT RNPQTARQAH LYRGIFPVLC KDPVQEAWAE DVDLRVNFAM NVGKARGFFK KGDVVIVLTG WRPGSGFTNT MRVVPVP // ID 1T5AB STANDARD; PRT; 567 AA. DT CONVERTED FROM PDB (SEQRES) 1T5A DE Pyruvate kinase, M2 isozyme OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.800 CC R-Factor 0.231 FT #SUB 58 22 MET B 440 404 ILE A Protein S 1 FT #SUB 60 24 ASP B 436 400 ARG A Protein S 1 FT #SUB 428 392 LEU B 436 400 ARG A Protein S 5 FT #SUB 432 396 GLU B 432 396 GLU A Protein S 9 FT #SUB 432 396 GLU B 435 399 ARG A Protein S 1 FT #SUB 435 399 ARG B 432 396 GLU A Protein S 1 FT #SUB 435 399 ARG B 435 399 ARG A Protein S 5 FT #SUB 435 399 ARG B 454 418 GLU A Protein S 11 FT #SUB 436 400 ARG B 60 24 ASP A Protein S 1 FT #SUB 436 400 ARG B 428 392 LEU A Protein S 7 FT #SUB 438 402 ALA B 458 422 LYS A Protein S 1 FT #SUB 439 403 PRO B 458 422 LYS A Protein B 1 FT #SUB 441 405 THR B 458 422 LYS A Protein A 3 FT #SUB 441 405 THR B 459 423 CYS A Protein B 2 FT #SUB 444 408 PRO B 563 527 VAL A Protein A 4 FT #SUB 446 410 GLU B 458 422 LYS A Protein S 1 FT #SUB 447 411 ALA B 455 419 ALA A Protein A 3 FT #SUB 447 411 ALA B 458 422 LYS A Protein B 1 FT #SUB 448 412 THR B 563 527 VAL A Protein S 2 FT #SUB 450 414 VAL B 454 418 GLU A Protein S 3 FT #SUB 450 414 VAL B 458 422 LYS A Protein S 2 FT #SUB 451 415 GLY B 451 415 GLY A Protein B 2 FT #SUB 454 418 GLU B 435 399 ARG A Protein S 8 FT #SUB 454 418 GLU B 450 414 VAL A Protein S 4 FT #SUB 454 418 GLU B 454 418 GLU A Protein S 4 FT #SUB 455 419 ALA B 447 411 ALA A Protein A 3 FT #SUB 458 422 LYS B 438 402 ALA A Protein S 1 FT #SUB 458 422 LYS B 439 403 PRO A Protein S 1 FT #SUB 458 422 LYS B 441 405 THR A Protein A 4 FT #SUB 458 422 LYS B 446 410 GLU A Protein S 1 FT #SUB 458 422 LYS B 447 411 ALA A Protein S 4 FT #SUB 458 422 LYS B 480 444 TYR A Protein S 2 FT #SUB 459 423 CYS B 441 405 THR A Protein B 1 FT #SUB 480 444 TYR B 458 422 LYS A Protein S 2 FT #SUB 559 523 ASN B 561 525 MET A Protein B 1 FT #SUB 559 523 ASN B 562 526 ARG A Protein A 5 FT #SUB 559 523 ASN B 563 527 VAL A Protein A 6 FT #SUB 560 524 THR B 561 525 MET A Protein B 2 FT #SUB 560 524 THR B 562 526 ARG A Protein S 4 FT #SUB 561 525 MET B 559 523 ASN A Protein B 1 FT #SUB 561 525 MET B 560 524 THR A Protein B 2 FT #SUB 561 525 MET B 561 525 MET A Protein A 10 FT #SUB 562 526 ARG B 559 523 ASN A Protein A 4 FT #SUB 562 526 ARG B 560 524 THR A Protein S 3 FT #SUB 563 527 VAL B 444 408 PRO A Protein S 3 FT #SUB 563 527 VAL B 448 412 THR A Protein S 2 FT #SUB 563 527 VAL B 559 523 ASN A Protein B 6 FT #SUB 60 24 ASP B 60 24 ASP C Protein S 9 FT #SUB 53 17 GLN B 344 308 LEU D Protein S 1 FT #SUB 61 25 THR B 433 397 GLU D Protein A 10 FT #SUB 62 26 PHE B 62 26 PHE D Protein S 1 FT #SUB 62 26 PHE B 429 393 GLN D Protein S 2 FT #SUB 62 26 PHE B 433 397 GLU D Protein A 8 FT #SUB 63 27 LEU B 351 315 GLY D Protein S 2 FT #SUB 63 27 LEU B 433 397 GLU D Protein A 4 FT #SUB 63 27 LEU B 434 398 LEU D Protein S 1 FT #SUB 63 27 LEU B 437 401 LEU D Protein S 3 FT #SUB 64 28 GLU B 355 319 ARG D Protein S 2 FT #SUB 64 28 GLU B 437 401 LEU D Protein S 1 FT #SUB 66 30 MET B 347 311 LYS D Protein A 2 FT #SUB 66 30 MET B 348 312 MET D Protein B 3 FT #SUB 67 31 CYS B 348 312 MET D Protein B 1 FT #SUB 67 31 CYS B 351 315 GLY D Protein S 2 FT #SUB 67 31 CYS B 352 316 ARG D Protein A 11 FT #SUB 67 31 CYS B 355 319 ARG D Protein S 5 FT #SUB 69 33 LEU B 344 308 LEU D Protein S 1 FT #SUB 69 33 LEU B 347 311 LYS D Protein S 1 FT #SUB 69 33 LEU B 348 312 MET D Protein B 2 FT #SUB 71 35 ILE B 310 274 HIS D Protein S 2 FT #SUB 71 35 ILE B 313 277 VAL D Protein S 2 FT #SUB 71 35 ILE B 337 301 ILE D Protein S 2 FT #SUB 71 35 ILE B 341 305 LYS D Protein A 4 FT #SUB 71 35 ILE B 344 308 LEU D Protein S 1 FT #SUB 71 35 ILE B 345 309 ALA D Protein S 2 FT #SUB 72 36 ASP B 310 274 HIS D Protein S 5 FT #SUB 72 36 ASP B 314 278 ARG D Protein S 3 FT #SUB 75 39 PRO B 341 305 LYS D Protein S 1 FT #SUB 214 178 ASP B 378 342 ARG D Protein S 1 FT #SUB 215 179 GLY B 375 339 ARG D Protein B 1 FT #SUB 216 180 LEU B 373 337 LYS D Protein S 1 FT #SUB 310 274 HIS B 71 35 ILE D Protein S 2 FT #SUB 310 274 HIS B 72 36 ASP D Protein S 4 FT #SUB 313 277 VAL B 71 35 ILE D Protein S 1 FT #SUB 314 278 ARG B 72 36 ASP D Protein S 1 FT #SUB 330 294 ARG B 378 342 ARG D Protein A 11 FT #SUB 330 294 ARG B 382 346 SER D Protein S 2 FT #SUB 331 295 GLY B 378 342 ARG D Protein B 7 FT #SUB 334 298 GLY B 378 342 ARG D Protein B 5 FT #SUB 335 299 ILE B 378 342 ARG D Protein S 2 FT #SUB 337 301 ILE B 71 35 ILE D Protein S 1 FT #SUB 340 304 GLU B 416 380 LEU D Protein S 4 FT #SUB 340 304 GLU B 417 381 ILE D Protein S 3 FT #SUB 340 304 GLU B 420 384 GLU D Protein A 3 FT #SUB 341 305 LYS B 71 35 ILE D Protein A 4 FT #SUB 341 305 LYS B 420 384 GLU D Protein S 7 FT #SUB 343 307 PHE B 385 349 ALA D Protein S 5 FT #SUB 343 307 PHE B 420 384 GLU D Protein S 3 FT #SUB 343 307 PHE B 421 385 ALA D Protein S 3 FT #SUB 344 308 LEU B 53 17 GLN D Protein S 1 FT #SUB 344 308 LEU B 69 33 LEU D Protein B 1 FT #SUB 344 308 LEU B 71 35 ILE D Protein S 1 FT #SUB 344 308 LEU B 420 384 GLU D Protein S 1 FT #SUB 344 308 LEU B 424 388 ALA D Protein S 1 FT #SUB 345 309 ALA B 71 35 ILE D Protein A 2 FT #SUB 347 311 LYS B 66 30 MET D Protein B 1 FT #SUB 347 311 LYS B 69 33 LEU D Protein S 1 FT #SUB 347 311 LYS B 386 350 ASN D Protein S 2 FT #SUB 347 311 LYS B 389 353 LEU D Protein S 2 FT #SUB 348 312 MET B 66 30 MET D Protein A 3 FT #SUB 348 312 MET B 67 31 CYS D Protein S 1 FT #SUB 348 312 MET B 69 33 LEU D Protein S 2 FT #SUB 351 315 GLY B 63 27 LEU D Protein B 1 FT #SUB 351 315 GLY B 67 31 CYS D Protein B 2 FT #SUB 352 316 ARG B 67 31 CYS D Protein A 10 FT #SUB 355 319 ARG B 64 28 GLU D Protein S 1 FT #SUB 355 319 ARG B 67 31 CYS D Protein S 5 FT #SUB 364 328 THR B 378 342 ARG D Protein B 1 FT #SUB 365 329 GLN B 377 341 THR D Protein S 4 FT #SUB 365 329 GLN B 378 342 ARG D Protein S 8 FT #SUB 365 329 GLN B 379 343 ALA D Protein B 1 FT #SUB 373 337 LYS B 216 180 LEU D Protein S 1 FT #SUB 375 339 ARG B 211 175 TYR D Protein S 1 FT #SUB 375 339 ARG B 215 179 GLY D Protein S 2 FT #SUB 377 341 THR B 365 329 GLN D Protein A 6 FT #SUB 378 342 ARG B 214 178 ASP D Protein S 1 FT #SUB 378 342 ARG B 330 294 ARG D Protein S 11 FT #SUB 378 342 ARG B 331 295 GLY D Protein S 8 FT #SUB 378 342 ARG B 334 298 GLY D Protein S 5 FT #SUB 378 342 ARG B 335 299 ILE D Protein S 2 FT #SUB 378 342 ARG B 364 328 THR D Protein S 1 FT #SUB 378 342 ARG B 365 329 GLN D Protein A 8 FT #SUB 379 343 ALA B 365 329 GLN D Protein S 1 FT #SUB 379 343 ALA B 366 330 MET D Protein S 1 FT #SUB 379 343 ALA B 379 343 ALA D Protein B 1 FT #SUB 379 343 ALA B 383 347 ASP D Protein A 8 FT #SUB 382 346 SER B 330 294 ARG D Protein S 2 FT #SUB 382 346 SER B 383 347 ASP D Protein S 4 FT #SUB 383 347 ASP B 379 343 ALA D Protein S 8 FT #SUB 383 347 ASP B 382 346 SER D Protein S 4 FT #SUB 385 349 ALA B 343 307 PHE D Protein S 6 FT #SUB 386 350 ASN B 347 311 LYS D Protein S 2 FT #SUB 386 350 ASN B 386 350 ASN D Protein S 11 FT #SUB 389 353 LEU B 347 311 LYS D Protein S 1 FT #SUB 416 380 LEU B 340 304 GLU D Protein A 7 FT #SUB 417 381 ILE B 340 304 GLU D Protein A 3 FT #SUB 420 384 GLU B 340 304 GLU D Protein S 3 FT #SUB 420 384 GLU B 341 305 LYS D Protein S 8 FT #SUB 420 384 GLU B 343 307 PHE D Protein A 3 FT #SUB 420 384 GLU B 344 308 LEU D Protein S 1 FT #SUB 421 385 ALA B 343 307 PHE D Protein A 4 FT #SUB 424 388 ALA B 343 307 PHE D Protein S 1 FT #SUB 424 388 ALA B 344 308 LEU D Protein S 1 FT #SUB 429 393 GLN B 62 26 PHE D Protein S 1 FT #SUB 429 393 GLN B 429 393 GLN D Protein S 5 FT #SUB 433 397 GLU B 61 25 THR D Protein S 10 FT #SUB 433 397 GLU B 62 26 PHE D Protein S 9 FT #SUB 433 397 GLU B 63 27 LEU D Protein S 4 FT #SUB 434 398 LEU B 63 27 LEU D Protein S 1 FT #SUB 437 401 LEU B 63 27 LEU D Protein S 3 FT #SUB 437 401 LEU B 64 28 GLU D Protein S 1 FT #HET 79 43 ARG B 18 705 GOL B S 1 FT #HET 102 66 LYS B 18 705 GOL B B 2 FT #HET 103 67 SER B 18 705 GOL B B 1 FT #HET 111 75 ASN B 13 534 PO4 B S 1 FT #HET 111 75 ASN B 15 702 K B S 2 FT #HET 113 77 SER B 15 702 K B S 2 FT #HET 114 78 HIS B 13 534 PO4 B S 5 FT #HET 114 78 HIS B 16 703 GOL B S 5 FT #HET 115 79 GLY B 16 703 GOL B B 1 FT #HET 142 106 ARG B 18 705 GOL B S 3 FT #HET 149 113 ASP B 15 702 K B S 1 FT #HET 150 114 THR B 15 702 K B B 1 FT #HET 156 120 ARG B 13 534 PO4 B S 5 FT #HET 242 206 LYS B 16 703 GOL B S 2 FT #HET 279 243 SER B 15 702 K B S 1 FT #HET 291 255 ARG B 19 706 GOL B S 2 FT #HET 306 270 LYS B 12 533 OXL B S 3 FT #HET 306 270 LYS B 14 602 MG B S 1 FT #HET 308 272 GLU B 12 533 OXL B S 6 FT #HET 308 272 GLU B 14 602 MG B S 2 FT #HET 321 285 GLU B 19 706 GOL B A 4 FT #HET 322 286 ALA B 19 706 GOL B B 4 FT #HET 324 288 ASP B 19 706 GOL B S 1 FT #HET 329 293 ALA B 12 533 OXL B A 10 FT #HET 330 294 ARG B 12 533 OXL B B 2 FT #HET 331 295 GLY B 12 533 OXL B B 4 FT #HET 332 296 ASP B 12 533 OXL B A 7 FT #HET 332 296 ASP B 14 602 MG B S 2 FT #HET 358 322 LYS B 19 706 GOL B S 2 FT #HET 364 328 THR B 12 533 OXL B S 6 FT #HET 396 360 MET B 12 533 OXL B S 1 FT #HET 415 379 ASN B 18 705 GOL B S 1 FT #HET 467 431 LEU B 11 532 FBP B A 5 FT #HET 468 432 THR B 11 532 FBP B A 7 FT #HET 469 433 LYS B 11 532 FBP B A 16 FT #HET 470 434 SER B 11 532 FBP B A 7 FT #HET 471 435 GLY B 11 532 FBP B B 1 FT #HET 472 436 ARG B 11 532 FBP B A 2 FT #HET 473 437 SER B 11 532 FBP B A 8 FT #HET 518 482 TRP B 11 532 FBP B S 4 FT #HET 518 482 TRP B 17 704 GOL B S 1 FT #HET 519 483 ALA B 17 704 GOL B A 4 FT #HET 522 486 VAL B 17 704 GOL B S 2 FT #HET 523 487 ASP B 17 704 GOL B S 3 FT #HET 525 489 ARG B 11 532 FBP B S 9 FT #HET 536 500 ARG B 18 705 GOL B S 1 FT #HET 550 514 GLY B 11 532 FBP B B 4 FT #HET 550 514 GLY B 17 704 GOL B B 1 FT #HET 552 516 ARG B 11 532 FBP B B 2 FT #HET 553 517 PRO B 11 532 FBP B A 4 FT #HET 554 518 GLY B 11 532 FBP B B 11 FT #HET 555 519 SER B 11 532 FBP B A 12 FT #HET 556 520 GLY B 11 532 FBP B B 4 FT #HET 557 521 PHE B 11 532 FBP B A 4 FT #HET 558 522 THR B 11 532 FBP B A 4 FT DISORDER 1 48 CC SEQUENCE 519 AA (ATOM); CC IQTQQLHAAM ADTFLEHMCR LDIDSPPITA RNTGIICTIG PASRSVETLK EMIKSGMNVA CC RLNFSHGTHE YHAETIKNVR TATESFASDP ILYRPVAVAL DTKGPEIRTG LIKGSGTAEV CC ELKKGATLKI TLDNAYMEKC DENILWLDYK NICKVVEVGS KIYVDDGLIS LQVKQKGADF CC LVTEVENGGS LGSKKGVNLP GAAVDLPAVS EKDIQDLKFG VEQDVDMVFA SFIRKASDVH CC EVRKVLGEKG KNIKIISKIE NHEGVRRFDE ILEASDGIMV ARGDLGIEIP AEKVFLAQKM CC MIGRCNRAGK PVICATQMLE SMIKKPRPTR AEGSDVANAV LDGADCIMLS GETAKGDYPL CC EAVRMQNLIA REAEAAIYHL QLFEELRRLA PITSDPTEAT AVGAVEASFK CCSGAIIVLT CC KSGRSAHQVA RYRPRAPIIA VTRNPQTARQ AHLYRGIFPV LCKDPVQEAW AEDVDLRVNF CC AMNVGKARGF FKKGDVVIVL TGWRPGSGFT NTMRVVPVP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDHPFTMSKPHSEAGTAFIQ CC ATOM ------------------------------------------------IQ CC ** CC SEQRES TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEM CC ATOM TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEM CC ************************************************** CC SEQRES IKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDT CC ATOM IKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDT CC ************************************************** CC SEQRES KGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI CC ATOM KGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI CC ************************************************** CC SEQRES CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGA CC ATOM CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGA CC ************************************************** CC SEQRES AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN CC ATOM AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN CC ************************************************** CC SEQRES IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI CC ATOM IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI CC ************************************************** CC SEQRES GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE CC ATOM GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE CC ************************************************** CC SEQRES TAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV CC ATOM TAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV CC ************************************************** CC SEQRES GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAH CC ATOM GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAH CC ************************************************** CC SEQRES LYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG CC ATOM LYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG CC ************************************************** CC SEQRES WRPGSGFTNTMRVVPVP CC ATOM WRPGSGFTNTMRVVPVP CC ***************** SQ SEQUENCE 567 AA; MW; CN; MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDHPFTMSKP HSEAGTAFIQ TQQLHAAMAD TFLEHMCRLD IDSPPITARN TGIICTIGPA SRSVETLKEM IKSGMNVARL NFSHGTHEYH AETIKNVRTA TESFASDPIL YRPVAVALDT KGPEIRTGLI KGSGTAEVEL KKGATLKITL DNAYMEKCDE NILWLDYKNI CKVVEVGSKI YVDDGLISLQ VKQKGADFLV TEVENGGSLG SKKGVNLPGA AVDLPAVSEK DIQDLKFGVE QDVDMVFASF IRKASDVHEV RKVLGEKGKN IKIISKIENH EGVRRFDEIL EASDGIMVAR GDLGIEIPAE KVFLAQKMMI GRCNRAGKPV ICATQMLESM IKKPRPTRAE GSDVANAVLD GADCIMLSGE TAKGDYPLEA VRMQNLIARE AEAAIYHLQL FEELRRLAPI TSDPTEATAV GAVEASFKCC SGAIIVLTKS GRSAHQVARY RPRAPIIAVT RNPQTARQAH LYRGIFPVLC KDPVQEAWAE DVDLRVNFAM NVGKARGFFK KGDVVIVLTG WRPGSGFTNT MRVVPVP // ID 1T5AC STANDARD; PRT; 567 AA. DT CONVERTED FROM PDB (SEQRES) 1T5A DE Pyruvate kinase, M2 isozyme OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.800 CC R-Factor 0.231 FT #SUB 61 25 THR C 433 397 GLU A Protein A 10 FT #SUB 62 26 PHE C 62 26 PHE A Protein S 1 FT #SUB 62 26 PHE C 429 393 GLN A Protein S 2 FT #SUB 62 26 PHE C 433 397 GLU A Protein A 9 FT #SUB 63 27 LEU C 351 315 GLY A Protein S 1 FT #SUB 63 27 LEU C 433 397 GLU A Protein A 4 FT #SUB 63 27 LEU C 434 398 LEU A Protein S 1 FT #SUB 63 27 LEU C 437 401 LEU A Protein S 3 FT #SUB 64 28 GLU C 437 401 LEU A Protein S 1 FT #SUB 66 30 MET C 348 312 MET A Protein B 3 FT #SUB 67 31 CYS C 348 312 MET A Protein B 1 FT #SUB 67 31 CYS C 351 315 GLY A Protein S 2 FT #SUB 67 31 CYS C 352 316 ARG A Protein A 8 FT #SUB 67 31 CYS C 355 319 ARG A Protein S 5 FT #SUB 69 33 LEU C 347 311 LYS A Protein S 1 FT #SUB 69 33 LEU C 348 312 MET A Protein B 2 FT #SUB 71 35 ILE C 310 274 HIS A Protein S 2 FT #SUB 71 35 ILE C 313 277 VAL A Protein S 1 FT #SUB 71 35 ILE C 341 305 LYS A Protein A 4 FT #SUB 71 35 ILE C 344 308 LEU A Protein S 1 FT #SUB 71 35 ILE C 345 309 ALA A Protein S 1 FT #SUB 72 36 ASP C 310 274 HIS A Protein S 4 FT #SUB 214 178 ASP C 378 342 ARG A Protein S 1 FT #SUB 215 179 GLY C 375 339 ARG A Protein B 1 FT #SUB 216 180 LEU C 373 337 LYS A Protein S 1 FT #SUB 310 274 HIS C 71 35 ILE A Protein S 2 FT #SUB 310 274 HIS C 72 36 ASP A Protein S 4 FT #SUB 313 277 VAL C 71 35 ILE A Protein S 1 FT #SUB 314 278 ARG C 72 36 ASP A Protein S 1 FT #SUB 330 294 ARG C 378 342 ARG A Protein A 8 FT #SUB 330 294 ARG C 382 346 SER A Protein S 2 FT #SUB 331 295 GLY C 378 342 ARG A Protein B 6 FT #SUB 334 298 GLY C 378 342 ARG A Protein B 5 FT #SUB 335 299 ILE C 378 342 ARG A Protein S 2 FT #SUB 337 301 ILE C 71 35 ILE A Protein S 2 FT #SUB 340 304 GLU C 416 380 LEU A Protein S 4 FT #SUB 340 304 GLU C 417 381 ILE A Protein A 4 FT #SUB 340 304 GLU C 420 384 GLU A Protein A 3 FT #SUB 341 305 LYS C 71 35 ILE A Protein A 4 FT #SUB 341 305 LYS C 420 384 GLU A Protein S 7 FT #SUB 343 307 PHE C 385 349 ALA A Protein S 6 FT #SUB 343 307 PHE C 420 384 GLU A Protein S 3 FT #SUB 343 307 PHE C 421 385 ALA A Protein S 3 FT #SUB 344 308 LEU C 53 17 GLN A Protein S 1 FT #SUB 344 308 LEU C 69 33 LEU A Protein B 1 FT #SUB 344 308 LEU C 71 35 ILE A Protein S 1 FT #SUB 344 308 LEU C 420 384 GLU A Protein S 1 FT #SUB 344 308 LEU C 424 388 ALA A Protein S 1 FT #SUB 345 309 ALA C 71 35 ILE A Protein A 2 FT #SUB 347 311 LYS C 66 30 MET A Protein B 2 FT #SUB 347 311 LYS C 69 33 LEU A Protein S 1 FT #SUB 347 311 LYS C 386 350 ASN A Protein S 2 FT #SUB 347 311 LYS C 389 353 LEU A Protein S 1 FT #SUB 348 312 MET C 66 30 MET A Protein A 3 FT #SUB 348 312 MET C 67 31 CYS A Protein S 1 FT #SUB 348 312 MET C 69 33 LEU A Protein S 2 FT #SUB 351 315 GLY C 63 27 LEU A Protein B 2 FT #SUB 351 315 GLY C 67 31 CYS A Protein B 2 FT #SUB 352 316 ARG C 67 31 CYS A Protein A 11 FT #SUB 355 319 ARG C 64 28 GLU A Protein S 2 FT #SUB 355 319 ARG C 67 31 CYS A Protein S 4 FT #SUB 365 329 GLN C 377 341 THR A Protein S 4 FT #SUB 365 329 GLN C 378 342 ARG A Protein S 8 FT #SUB 365 329 GLN C 379 343 ALA A Protein B 1 FT #SUB 373 337 LYS C 216 180 LEU A Protein S 1 FT #SUB 375 339 ARG C 215 179 GLY A Protein S 1 FT #SUB 377 341 THR C 365 329 GLN A Protein A 4 FT #SUB 378 342 ARG C 214 178 ASP A Protein S 1 FT #SUB 378 342 ARG C 330 294 ARG A Protein S 9 FT #SUB 378 342 ARG C 331 295 GLY A Protein S 4 FT #SUB 378 342 ARG C 334 298 GLY A Protein S 7 FT #SUB 378 342 ARG C 335 299 ILE A Protein S 2 FT #SUB 378 342 ARG C 365 329 GLN A Protein A 4 FT #SUB 379 343 ALA C 365 329 GLN A Protein S 1 FT #SUB 379 343 ALA C 379 343 ALA A Protein B 1 FT #SUB 379 343 ALA C 383 347 ASP A Protein A 7 FT #SUB 382 346 SER C 330 294 ARG A Protein S 1 FT #SUB 382 346 SER C 383 347 ASP A Protein S 3 FT #SUB 383 347 ASP C 379 343 ALA A Protein S 5 FT #SUB 383 347 ASP C 382 346 SER A Protein S 3 FT #SUB 385 349 ALA C 343 307 PHE A Protein S 6 FT #SUB 386 350 ASN C 347 311 LYS A Protein S 2 FT #SUB 386 350 ASN C 386 350 ASN A Protein S 11 FT #SUB 389 353 LEU C 347 311 LYS A Protein S 1 FT #SUB 413 377 MET C 340 304 GLU A Protein S 1 FT #SUB 416 380 LEU C 340 304 GLU A Protein S 3 FT #SUB 417 381 ILE C 340 304 GLU A Protein S 1 FT #SUB 420 384 GLU C 340 304 GLU A Protein S 2 FT #SUB 420 384 GLU C 341 305 LYS A Protein S 6 FT #SUB 420 384 GLU C 343 307 PHE A Protein A 2 FT #SUB 420 384 GLU C 344 308 LEU A Protein S 1 FT #SUB 421 385 ALA C 343 307 PHE A Protein A 3 FT #SUB 424 388 ALA C 344 308 LEU A Protein S 1 FT #SUB 429 393 GLN C 62 26 PHE A Protein S 1 FT #SUB 429 393 GLN C 429 393 GLN A Protein S 5 FT #SUB 433 397 GLU C 61 25 THR A Protein S 12 FT #SUB 433 397 GLU C 62 26 PHE A Protein S 9 FT #SUB 433 397 GLU C 63 27 LEU A Protein S 4 FT #SUB 434 398 LEU C 63 27 LEU A Protein S 1 FT #SUB 437 401 LEU C 63 27 LEU A Protein S 2 FT #SUB 437 401 LEU C 64 28 GLU A Protein S 1 FT #SUB 60 24 ASP C 60 24 ASP B Protein S 9 FT #SUB 58 22 MET C 440 404 ILE D Protein S 1 FT #SUB 60 24 ASP C 436 400 ARG D Protein S 1 FT #SUB 428 392 LEU C 436 400 ARG D Protein S 6 FT #SUB 432 396 GLU C 432 396 GLU D Protein S 11 FT #SUB 432 396 GLU C 435 399 ARG D Protein S 1 FT #SUB 435 399 ARG C 432 396 GLU D Protein S 1 FT #SUB 435 399 ARG C 435 399 ARG D Protein S 5 FT #SUB 435 399 ARG C 454 418 GLU D Protein S 11 FT #SUB 436 400 ARG C 60 24 ASP D Protein S 1 FT #SUB 436 400 ARG C 428 392 LEU D Protein S 7 FT #SUB 438 402 ALA C 458 422 LYS D Protein S 1 FT #SUB 439 403 PRO C 458 422 LYS D Protein B 1 FT #SUB 440 404 ILE C 58 22 MET D Protein S 1 FT #SUB 441 405 THR C 458 422 LYS D Protein A 4 FT #SUB 441 405 THR C 459 423 CYS D Protein B 2 FT #SUB 444 408 PRO C 563 527 VAL D Protein A 3 FT #SUB 446 410 GLU C 458 422 LYS D Protein S 1 FT #SUB 447 411 ALA C 455 419 ALA D Protein A 3 FT #SUB 447 411 ALA C 458 422 LYS D Protein B 1 FT #SUB 448 412 THR C 563 527 VAL D Protein S 1 FT #SUB 450 414 VAL C 454 418 GLU D Protein S 3 FT #SUB 450 414 VAL C 458 422 LYS D Protein S 1 FT #SUB 451 415 GLY C 451 415 GLY D Protein B 2 FT #SUB 454 418 GLU C 435 399 ARG D Protein S 10 FT #SUB 454 418 GLU C 450 414 VAL D Protein S 3 FT #SUB 454 418 GLU C 454 418 GLU D Protein S 4 FT #SUB 455 419 ALA C 447 411 ALA D Protein A 2 FT #SUB 458 422 LYS C 439 403 PRO D Protein S 1 FT #SUB 458 422 LYS C 441 405 THR D Protein A 4 FT #SUB 458 422 LYS C 446 410 GLU D Protein S 1 FT #SUB 458 422 LYS C 447 411 ALA D Protein S 3 FT #SUB 458 422 LYS C 480 444 TYR D Protein S 2 FT #SUB 459 423 CYS C 441 405 THR D Protein B 1 FT #SUB 480 444 TYR C 458 422 LYS D Protein S 2 FT #SUB 559 523 ASN C 561 525 MET D Protein B 1 FT #SUB 559 523 ASN C 562 526 ARG D Protein A 4 FT #SUB 559 523 ASN C 563 527 VAL D Protein A 6 FT #SUB 560 524 THR C 561 525 MET D Protein B 2 FT #SUB 560 524 THR C 562 526 ARG D Protein S 1 FT #SUB 561 525 MET C 559 523 ASN D Protein B 1 FT #SUB 561 525 MET C 560 524 THR D Protein B 2 FT #SUB 561 525 MET C 561 525 MET D Protein A 7 FT #SUB 562 526 ARG C 559 523 ASN D Protein A 3 FT #SUB 562 526 ARG C 560 524 THR D Protein S 1 FT #SUB 563 527 VAL C 444 408 PRO D Protein S 1 FT #SUB 563 527 VAL C 448 412 THR D Protein S 1 FT #SUB 563 527 VAL C 559 523 ASN D Protein B 6 FT #HET 79 43 ARG C 29 708 GOL C S 2 FT #HET 102 66 LYS C 29 708 GOL C B 3 FT #HET 103 67 SER C 29 708 GOL C B 2 FT #HET 104 68 GLY C 29 708 GOL C B 2 FT #HET 111 75 ASN C 22 534 PO4 C S 1 FT #HET 111 75 ASN C 24 703 K C S 2 FT #HET 113 77 SER C 24 703 K C S 2 FT #HET 114 78 HIS C 22 534 PO4 C S 4 FT #HET 114 78 HIS C 25 704 GOL C S 3 FT #HET 115 79 GLY C 25 704 GOL C B 1 FT #HET 142 106 ARG C 29 708 GOL C S 4 FT #HET 149 113 ASP C 24 703 K C A 3 FT #HET 150 114 THR C 24 703 K C B 2 FT #HET 153 117 PRO C 27 706 GOL C A 4 FT #HET 156 120 ARG C 22 534 PO4 C S 5 FT #HET 242 206 LYS C 25 704 GOL C S 4 FT #HET 245 209 VAL C 27 706 GOL C B 1 FT #HET 246 210 ASN C 27 706 GOL C A 4 FT #HET 247 211 LEU C 27 706 GOL C B 2 FT #HET 252 216 VAL C 27 706 GOL C S 3 FT #HET 280 244 PHE C 27 706 GOL C S 6 FT #HET 291 255 ARG C 30 709 GOL C S 1 FT #HET 306 270 LYS C 21 533 OXL C S 3 FT #HET 306 270 LYS C 23 603 MG C S 1 FT #HET 308 272 GLU C 21 533 OXL C S 7 FT #HET 308 272 GLU C 23 603 MG C S 3 FT #HET 321 285 GLU C 30 709 GOL C A 7 FT #HET 322 286 ALA C 30 709 GOL C B 2 FT #HET 323 287 SER C 30 709 GOL C B 1 FT #HET 324 288 ASP C 30 709 GOL C S 1 FT #HET 329 293 ALA C 21 533 OXL C A 7 FT #HET 331 295 GLY C 21 533 OXL C B 3 FT #HET 332 296 ASP C 21 533 OXL C A 7 FT #HET 332 296 ASP C 23 603 MG C S 2 FT #HET 336 300 GLU C 27 706 GOL C S 7 FT #HET 353 317 CYS C 28 707 GOL C A 7 FT #HET 354 318 ASN C 28 707 GOL C A 11 FT #HET 357 321 GLY C 28 707 GOL C B 8 FT #HET 358 322 LYS C 28 707 GOL C B 6 FT #HET 358 322 LYS C 30 709 GOL C S 5 FT #HET 364 328 THR C 21 533 OXL C S 6 FT #HET 393 357 ASP C 28 707 GOL C S 5 FT #HET 415 379 ASN C 29 708 GOL C S 2 FT #HET 467 431 LEU C 20 532 FBP C A 5 FT #HET 468 432 THR C 20 532 FBP C A 6 FT #HET 469 433 LYS C 20 532 FBP C A 12 FT #HET 470 434 SER C 20 532 FBP C A 6 FT #HET 472 436 ARG C 20 532 FBP C A 2 FT #HET 473 437 SER C 20 532 FBP C A 8 FT #HET 479 443 ARG C 28 707 GOL C A 2 FT #HET 481 445 ARG C 28 707 GOL C S 8 FT #HET 502 466 TYR C 28 707 GOL C S 2 FT #HET 518 482 TRP C 20 532 FBP C S 1 FT #HET 518 482 TRP C 26 705 GOL C S 1 FT #HET 523 487 ASP C 26 705 GOL C S 1 FT #HET 525 489 ARG C 20 532 FBP C S 10 FT #HET 536 500 ARG C 29 708 GOL C S 1 FT #HET 549 513 THR C 26 705 GOL C S 2 FT #HET 550 514 GLY C 20 532 FBP C B 4 FT #HET 552 516 ARG C 20 532 FBP C B 3 FT #HET 553 517 PRO C 20 532 FBP C A 4 FT #HET 554 518 GLY C 20 532 FBP C B 9 FT #HET 555 519 SER C 20 532 FBP C A 14 FT #HET 556 520 GLY C 20 532 FBP C B 5 FT #HET 557 521 PHE C 20 532 FBP C A 5 FT #HET 558 522 THR C 20 532 FBP C A 4 FT #HET 562 526 ARG C 26 705 GOL C S 3 FT DISORDER 1 48 CC SEQUENCE 519 AA (ATOM); CC IQTQQLHAAM ADTFLEHMCR LDIDSPPITA RNTGIICTIG PASRSVETLK EMIKSGMNVA CC RLNFSHGTHE YHAETIKNVR TATESFASDP ILYRPVAVAL DTKGPEIRTG LIKGSGTAEV CC ELKKGATLKI TLDNAYMEKC DENILWLDYK NICKVVEVGS KIYVDDGLIS LQVKQKGADF CC LVTEVENGGS LGSKKGVNLP GAAVDLPAVS EKDIQDLKFG VEQDVDMVFA SFIRKASDVH CC EVRKVLGEKG KNIKIISKIE NHEGVRRFDE ILEASDGIMV ARGDLGIEIP AEKVFLAQKM CC MIGRCNRAGK PVICATQMLE SMIKKPRPTR AEGSDVANAV LDGADCIMLS GETAKGDYPL CC EAVRMQNLIA REAEAAIYHL QLFEELRRLA PITSDPTEAT AVGAVEASFK CCSGAIIVLT CC KSGRSAHQVA RYRPRAPIIA VTRNPQTARQ AHLYRGIFPV LCKDPVQEAW AEDVDLRVNF CC AMNVGKARGF FKKGDVVIVL TGWRPGSGFT NTMRVVPVP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDHPFTMSKPHSEAGTAFIQ CC ATOM ------------------------------------------------IQ CC ** CC SEQRES TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEM CC ATOM TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEM CC ************************************************** CC SEQRES IKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDT CC ATOM IKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDT CC ************************************************** CC SEQRES KGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI CC ATOM KGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI CC ************************************************** CC SEQRES CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGA CC ATOM CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGA CC ************************************************** CC SEQRES AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN CC ATOM AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN CC ************************************************** CC SEQRES IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI CC ATOM IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI CC ************************************************** CC SEQRES GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE CC ATOM GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE CC ************************************************** CC SEQRES TAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV CC ATOM TAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV CC ************************************************** CC SEQRES GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAH CC ATOM GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAH CC ************************************************** CC SEQRES LYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG CC ATOM LYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG CC ************************************************** CC SEQRES WRPGSGFTNTMRVVPVP CC ATOM WRPGSGFTNTMRVVPVP CC ***************** SQ SEQUENCE 567 AA; MW; CN; MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDHPFTMSKP HSEAGTAFIQ TQQLHAAMAD TFLEHMCRLD IDSPPITARN TGIICTIGPA SRSVETLKEM IKSGMNVARL NFSHGTHEYH AETIKNVRTA TESFASDPIL YRPVAVALDT KGPEIRTGLI KGSGTAEVEL KKGATLKITL DNAYMEKCDE NILWLDYKNI CKVVEVGSKI YVDDGLISLQ VKQKGADFLV TEVENGGSLG SKKGVNLPGA AVDLPAVSEK DIQDLKFGVE QDVDMVFASF IRKASDVHEV RKVLGEKGKN IKIISKIENH EGVRRFDEIL EASDGIMVAR GDLGIEIPAE KVFLAQKMMI GRCNRAGKPV ICATQMLESM IKKPRPTRAE GSDVANAVLD GADCIMLSGE TAKGDYPLEA VRMQNLIARE AEAAIYHLQL FEELRRLAPI TSDPTEATAV GAVEASFKCC SGAIIVLTKS GRSAHQVARY RPRAPIIAVT RNPQTARQAH LYRGIFPVLC KDPVQEAWAE DVDLRVNFAM NVGKARGFFK KGDVVIVLTG WRPGSGFTNT MRVVPVP // ID 1T5AD STANDARD; PRT; 567 AA. DT CONVERTED FROM PDB (SEQRES) 1T5A DE Pyruvate kinase, M2 isozyme OS Homo sapiens CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.800 CC R-Factor 0.231 FT #SUB 60 24 ASP D 60 24 ASP A Protein S 12 FT #SUB 53 17 GLN D 344 308 LEU B Protein S 1 FT #SUB 61 25 THR D 433 397 GLU B Protein A 10 FT #SUB 62 26 PHE D 62 26 PHE B Protein S 1 FT #SUB 62 26 PHE D 429 393 GLN B Protein S 1 FT #SUB 62 26 PHE D 433 397 GLU B Protein A 9 FT #SUB 63 27 LEU D 351 315 GLY B Protein S 1 FT #SUB 63 27 LEU D 433 397 GLU B Protein A 4 FT #SUB 63 27 LEU D 434 398 LEU B Protein S 1 FT #SUB 63 27 LEU D 437 401 LEU B Protein S 3 FT #SUB 64 28 GLU D 355 319 ARG B Protein S 1 FT #SUB 64 28 GLU D 437 401 LEU B Protein S 1 FT #SUB 66 30 MET D 347 311 LYS B Protein S 1 FT #SUB 66 30 MET D 348 312 MET B Protein B 3 FT #SUB 67 31 CYS D 348 312 MET B Protein B 1 FT #SUB 67 31 CYS D 351 315 GLY B Protein S 2 FT #SUB 67 31 CYS D 352 316 ARG B Protein A 10 FT #SUB 67 31 CYS D 355 319 ARG B Protein S 5 FT #SUB 69 33 LEU D 344 308 LEU B Protein S 1 FT #SUB 69 33 LEU D 347 311 LYS B Protein S 1 FT #SUB 69 33 LEU D 348 312 MET B Protein B 2 FT #SUB 71 35 ILE D 310 274 HIS B Protein S 2 FT #SUB 71 35 ILE D 313 277 VAL B Protein S 1 FT #SUB 71 35 ILE D 337 301 ILE B Protein S 1 FT #SUB 71 35 ILE D 341 305 LYS B Protein A 4 FT #SUB 71 35 ILE D 344 308 LEU B Protein S 1 FT #SUB 71 35 ILE D 345 309 ALA B Protein S 2 FT #SUB 72 36 ASP D 310 274 HIS B Protein S 4 FT #SUB 72 36 ASP D 314 278 ARG B Protein S 1 FT #SUB 211 175 TYR D 375 339 ARG B Protein S 1 FT #SUB 214 178 ASP D 378 342 ARG B Protein S 1 FT #SUB 215 179 GLY D 375 339 ARG B Protein B 2 FT #SUB 216 180 LEU D 373 337 LYS B Protein S 1 FT #SUB 310 274 HIS D 71 35 ILE B Protein S 2 FT #SUB 310 274 HIS D 72 36 ASP B Protein S 5 FT #SUB 313 277 VAL D 71 35 ILE B Protein S 2 FT #SUB 314 278 ARG D 72 36 ASP B Protein S 3 FT #SUB 330 294 ARG D 378 342 ARG B Protein A 11 FT #SUB 330 294 ARG D 382 346 SER B Protein S 2 FT #SUB 331 295 GLY D 378 342 ARG B Protein B 8 FT #SUB 334 298 GLY D 378 342 ARG B Protein B 5 FT #SUB 335 299 ILE D 378 342 ARG B Protein S 2 FT #SUB 337 301 ILE D 71 35 ILE B Protein S 2 FT #SUB 340 304 GLU D 416 380 LEU B Protein S 7 FT #SUB 340 304 GLU D 417 381 ILE B Protein S 3 FT #SUB 340 304 GLU D 420 384 GLU B Protein A 3 FT #SUB 341 305 LYS D 71 35 ILE B Protein A 4 FT #SUB 341 305 LYS D 75 39 PRO B Protein S 1 FT #SUB 341 305 LYS D 420 384 GLU B Protein S 8 FT #SUB 343 307 PHE D 385 349 ALA B Protein S 6 FT #SUB 343 307 PHE D 420 384 GLU B Protein S 3 FT #SUB 343 307 PHE D 421 385 ALA B Protein S 4 FT #SUB 343 307 PHE D 424 388 ALA B Protein S 1 FT #SUB 344 308 LEU D 53 17 GLN B Protein S 1 FT #SUB 344 308 LEU D 69 33 LEU B Protein B 1 FT #SUB 344 308 LEU D 71 35 ILE B Protein S 1 FT #SUB 344 308 LEU D 420 384 GLU B Protein S 1 FT #SUB 344 308 LEU D 424 388 ALA B Protein S 1 FT #SUB 345 309 ALA D 71 35 ILE B Protein A 2 FT #SUB 347 311 LYS D 66 30 MET B Protein B 2 FT #SUB 347 311 LYS D 69 33 LEU B Protein S 1 FT #SUB 347 311 LYS D 386 350 ASN B Protein S 2 FT #SUB 347 311 LYS D 389 353 LEU B Protein S 1 FT #SUB 348 312 MET D 66 30 MET B Protein A 3 FT #SUB 348 312 MET D 67 31 CYS B Protein S 1 FT #SUB 348 312 MET D 69 33 LEU B Protein S 2 FT #SUB 351 315 GLY D 63 27 LEU B Protein B 2 FT #SUB 351 315 GLY D 67 31 CYS B Protein B 2 FT #SUB 352 316 ARG D 67 31 CYS B Protein A 11 FT #SUB 355 319 ARG D 64 28 GLU B Protein S 2 FT #SUB 355 319 ARG D 67 31 CYS B Protein S 5 FT #SUB 364 328 THR D 378 342 ARG B Protein B 1 FT #SUB 365 329 GLN D 377 341 THR B Protein S 6 FT #SUB 365 329 GLN D 378 342 ARG B Protein S 8 FT #SUB 365 329 GLN D 379 343 ALA B Protein B 1 FT #SUB 366 330 MET D 379 343 ALA B Protein B 1 FT #SUB 373 337 LYS D 216 180 LEU B Protein S 1 FT #SUB 375 339 ARG D 215 179 GLY B Protein S 1 FT #SUB 377 341 THR D 365 329 GLN B Protein A 4 FT #SUB 378 342 ARG D 214 178 ASP B Protein S 1 FT #SUB 378 342 ARG D 330 294 ARG B Protein S 11 FT #SUB 378 342 ARG D 331 295 GLY B Protein S 7 FT #SUB 378 342 ARG D 334 298 GLY B Protein S 5 FT #SUB 378 342 ARG D 335 299 ILE B Protein S 2 FT #SUB 378 342 ARG D 364 328 THR B Protein S 1 FT #SUB 378 342 ARG D 365 329 GLN B Protein A 8 FT #SUB 379 343 ALA D 365 329 GLN B Protein S 1 FT #SUB 379 343 ALA D 379 343 ALA B Protein B 1 FT #SUB 379 343 ALA D 383 347 ASP B Protein A 8 FT #SUB 382 346 SER D 330 294 ARG B Protein S 2 FT #SUB 382 346 SER D 383 347 ASP B Protein S 4 FT #SUB 383 347 ASP D 379 343 ALA B Protein S 8 FT #SUB 383 347 ASP D 382 346 SER B Protein S 4 FT #SUB 385 349 ALA D 343 307 PHE B Protein S 5 FT #SUB 386 350 ASN D 347 311 LYS B Protein S 2 FT #SUB 386 350 ASN D 386 350 ASN B Protein S 11 FT #SUB 389 353 LEU D 347 311 LYS B Protein S 2 FT #SUB 416 380 LEU D 340 304 GLU B Protein A 4 FT #SUB 417 381 ILE D 340 304 GLU B Protein A 3 FT #SUB 420 384 GLU D 340 304 GLU B Protein S 3 FT #SUB 420 384 GLU D 341 305 LYS B Protein S 7 FT #SUB 420 384 GLU D 343 307 PHE B Protein A 3 FT #SUB 420 384 GLU D 344 308 LEU B Protein S 1 FT #SUB 421 385 ALA D 343 307 PHE B Protein A 3 FT #SUB 424 388 ALA D 344 308 LEU B Protein S 1 FT #SUB 429 393 GLN D 62 26 PHE B Protein S 2 FT #SUB 429 393 GLN D 429 393 GLN B Protein S 5 FT #SUB 433 397 GLU D 61 25 THR B Protein S 10 FT #SUB 433 397 GLU D 62 26 PHE B Protein S 8 FT #SUB 433 397 GLU D 63 27 LEU B Protein S 4 FT #SUB 434 398 LEU D 63 27 LEU B Protein S 1 FT #SUB 437 401 LEU D 63 27 LEU B Protein S 3 FT #SUB 437 401 LEU D 64 28 GLU B Protein S 1 FT #SUB 58 22 MET D 440 404 ILE C Protein S 1 FT #SUB 60 24 ASP D 436 400 ARG C Protein S 1 FT #SUB 428 392 LEU D 436 400 ARG C Protein S 7 FT #SUB 432 396 GLU D 432 396 GLU C Protein S 11 FT #SUB 432 396 GLU D 435 399 ARG C Protein S 1 FT #SUB 435 399 ARG D 432 396 GLU C Protein S 1 FT #SUB 435 399 ARG D 435 399 ARG C Protein S 5 FT #SUB 435 399 ARG D 454 418 GLU C Protein S 10 FT #SUB 436 400 ARG D 60 24 ASP C Protein S 1 FT #SUB 436 400 ARG D 428 392 LEU C Protein S 6 FT #SUB 439 403 PRO D 458 422 LYS C Protein B 1 FT #SUB 440 404 ILE D 58 22 MET C Protein S 1 FT #SUB 441 405 THR D 458 422 LYS C Protein A 4 FT #SUB 441 405 THR D 459 423 CYS C Protein B 1 FT #SUB 444 408 PRO D 563 527 VAL C Protein S 1 FT #SUB 446 410 GLU D 458 422 LYS C Protein S 1 FT #SUB 447 411 ALA D 455 419 ALA C Protein A 2 FT #SUB 447 411 ALA D 458 422 LYS C Protein A 3 FT #SUB 448 412 THR D 563 527 VAL C Protein S 1 FT #SUB 450 414 VAL D 454 418 GLU C Protein S 3 FT #SUB 451 415 GLY D 451 415 GLY C Protein B 2 FT #SUB 454 418 GLU D 435 399 ARG C Protein S 11 FT #SUB 454 418 GLU D 450 414 VAL C Protein S 3 FT #SUB 454 418 GLU D 454 418 GLU C Protein S 4 FT #SUB 455 419 ALA D 447 411 ALA C Protein A 3 FT #SUB 458 422 LYS D 438 402 ALA C Protein S 1 FT #SUB 458 422 LYS D 439 403 PRO C Protein S 1 FT #SUB 458 422 LYS D 441 405 THR C Protein A 4 FT #SUB 458 422 LYS D 446 410 GLU C Protein S 1 FT #SUB 458 422 LYS D 447 411 ALA C Protein S 1 FT #SUB 458 422 LYS D 450 414 VAL C Protein S 1 FT #SUB 458 422 LYS D 480 444 TYR C Protein S 2 FT #SUB 459 423 CYS D 441 405 THR C Protein A 2 FT #SUB 480 444 TYR D 458 422 LYS C Protein S 2 FT #SUB 559 523 ASN D 561 525 MET C Protein B 1 FT #SUB 559 523 ASN D 562 526 ARG C Protein B 3 FT #SUB 559 523 ASN D 563 527 VAL C Protein A 6 FT #SUB 560 524 THR D 561 525 MET C Protein B 2 FT #SUB 560 524 THR D 562 526 ARG C Protein S 1 FT #SUB 561 525 MET D 559 523 ASN C Protein B 1 FT #SUB 561 525 MET D 560 524 THR C Protein B 2 FT #SUB 561 525 MET D 561 525 MET C Protein A 7 FT #SUB 562 526 ARG D 559 523 ASN C Protein A 4 FT #SUB 562 526 ARG D 560 524 THR C Protein S 1 FT #SUB 563 527 VAL D 444 408 PRO C Protein S 3 FT #SUB 563 527 VAL D 448 412 THR C Protein S 1 FT #SUB 563 527 VAL D 559 523 ASN C Protein B 6 FT #HET 79 43 ARG D 39 708 GOL D S 1 FT #HET 102 66 LYS D 39 708 GOL D B 4 FT #HET 103 67 SER D 39 708 GOL D B 2 FT #HET 104 68 GLY D 39 708 GOL D B 4 FT #HET 111 75 ASN D 33 534 PO4 D S 1 FT #HET 111 75 ASN D 35 704 K D S 1 FT #HET 113 77 SER D 35 704 K D S 2 FT #HET 114 78 HIS D 33 534 PO4 D S 3 FT #HET 114 78 HIS D 36 705 GOL D A 7 FT #HET 115 79 GLY D 36 705 GOL D B 2 FT #HET 142 106 ARG D 39 708 GOL D S 3 FT #HET 149 113 ASP D 35 704 K D S 1 FT #HET 150 114 THR D 35 704 K D B 1 FT #HET 153 117 PRO D 38 707 GOL D B 3 FT #HET 154 118 GLU D 35 704 K D S 1 FT #HET 156 120 ARG D 33 534 PO4 D S 4 FT #HET 242 206 LYS D 36 705 GOL D S 3 FT #HET 245 209 VAL D 38 707 GOL D B 1 FT #HET 246 210 ASN D 38 707 GOL D B 3 FT #HET 247 211 LEU D 38 707 GOL D A 6 FT #HET 252 216 VAL D 38 707 GOL D S 3 FT #HET 279 243 SER D 35 704 K D S 1 FT #HET 280 244 PHE D 38 707 GOL D S 2 FT #HET 291 255 ARG D 40 709 GOL D S 2 FT #HET 306 270 LYS D 32 533 OXL D S 3 FT #HET 308 272 GLU D 32 533 OXL D S 7 FT #HET 308 272 GLU D 34 604 MG D S 1 FT #HET 321 285 GLU D 40 709 GOL D A 4 FT #HET 322 286 ALA D 40 709 GOL D B 3 FT #HET 323 287 SER D 40 709 GOL D B 1 FT #HET 324 288 ASP D 40 709 GOL D S 1 FT #HET 329 293 ALA D 32 533 OXL D A 7 FT #HET 330 294 ARG D 32 533 OXL D B 2 FT #HET 331 295 GLY D 32 533 OXL D B 3 FT #HET 332 296 ASP D 32 533 OXL D A 8 FT #HET 332 296 ASP D 34 604 MG D S 2 FT #HET 336 300 GLU D 38 707 GOL D S 7 FT #HET 358 322 LYS D 40 709 GOL D S 1 FT #HET 364 328 THR D 32 533 OXL D S 6 FT #HET 415 379 ASN D 39 708 GOL D S 2 FT #HET 467 431 LEU D 31 532 FBP D A 7 FT #HET 468 432 THR D 31 532 FBP D A 7 FT #HET 469 433 LYS D 31 532 FBP D A 13 FT #HET 470 434 SER D 31 532 FBP D A 7 FT #HET 471 435 GLY D 31 532 FBP D B 1 FT #HET 472 436 ARG D 31 532 FBP D A 2 FT #HET 473 437 SER D 31 532 FBP D A 8 FT #HET 518 482 TRP D 31 532 FBP D S 6 FT #HET 522 486 VAL D 37 706 GOL D S 1 FT #HET 523 487 ASP D 37 706 GOL D S 4 FT #HET 525 489 ARG D 31 532 FBP D S 11 FT #HET 549 513 THR D 37 706 GOL D S 2 FT #HET 550 514 GLY D 31 532 FBP D B 5 FT #HET 550 514 GLY D 37 706 GOL D B 1 FT #HET 552 516 ARG D 31 532 FBP D B 3 FT #HET 553 517 PRO D 31 532 FBP D A 4 FT #HET 554 518 GLY D 31 532 FBP D B 6 FT #HET 555 519 SER D 31 532 FBP D A 11 FT #HET 556 520 GLY D 31 532 FBP D B 4 FT #HET 557 521 PHE D 31 532 FBP D A 4 FT #HET 558 522 THR D 31 532 FBP D A 4 FT #HET 562 526 ARG D 37 706 GOL D S 5 FT DISORDER 1 48 CC SEQUENCE 519 AA (ATOM); CC IQTQQLHAAM ADTFLEHMCR LDIDSPPITA RNTGIICTIG PASRSVETLK EMIKSGMNVA CC RLNFSHGTHE YHAETIKNVR TATESFASDP ILYRPVAVAL DTKGPEIRTG LIKGSGTAEV CC ELKKGATLKI TLDNAYMEKC DENILWLDYK NICKVVEVGS KIYVDDGLIS LQVKQKGADF CC LVTEVENGGS LGSKKGVNLP GAAVDLPAVS EKDIQDLKFG VEQDVDMVFA SFIRKASDVH CC EVRKVLGEKG KNIKIISKIE NHEGVRRFDE ILEASDGIMV ARGDLGIEIP AEKVFLAQKM CC MIGRCNRAGK PVICATQMLE SMIKKPRPTR AEGSDVANAV LDGADCIMLS GETAKGDYPL CC EAVRMQNLIA REAEAAIYHL QLFEELRRLA PITSDPTEAT AVGAVEASFK CCSGAIIVLT CC KSGRSAHQVA RYRPRAPIIA VTRNPQTARQ AHLYRGIFPV LCKDPVQEAW AEDVDLRVNF CC AMNVGKARGF FKKGDVVIVL TGWRPGSGFT NTMRVVPVP CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDHPFTMSKPHSEAGTAFIQ CC ATOM ------------------------------------------------IQ CC ** CC SEQRES TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEM CC ATOM TQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEM CC ************************************************** CC SEQRES IKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDT CC ATOM IKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDT CC ************************************************** CC SEQRES KGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI CC ATOM KGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNI CC ************************************************** CC SEQRES CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGA CC ATOM CKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGA CC ************************************************** CC SEQRES AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN CC ATOM AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKN CC ************************************************** CC SEQRES IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI CC ATOM IKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMI CC ************************************************** CC SEQRES GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE CC ATOM GRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGE CC ************************************************** CC SEQRES TAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV CC ATOM TAKGDYPLEAVRMQNLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAV CC ************************************************** CC SEQRES GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAH CC ATOM GAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAH CC ************************************************** CC SEQRES LYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG CC ATOM LYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTG CC ************************************************** CC SEQRES WRPGSGFTNTMRVVPVP CC ATOM WRPGSGFTNTMRVVPVP CC ***************** SQ SEQUENCE 567 AA; MW; CN; MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDHPFTMSKP HSEAGTAFIQ TQQLHAAMAD TFLEHMCRLD IDSPPITARN TGIICTIGPA SRSVETLKEM IKSGMNVARL NFSHGTHEYH AETIKNVRTA TESFASDPIL YRPVAVALDT KGPEIRTGLI KGSGTAEVEL KKGATLKITL DNAYMEKCDE NILWLDYKNI CKVVEVGSKI YVDDGLISLQ VKQKGADFLV TEVENGGSLG SKKGVNLPGA AVDLPAVSEK DIQDLKFGVE QDVDMVFASF IRKASDVHEV RKVLGEKGKN IKIISKIENH EGVRRFDEIL EASDGIMVAR GDLGIEIPAE KVFLAQKMMI GRCNRAGKPV ICATQMLESM IKKPRPTRAE GSDVANAVLD GADCIMLSGE TAKGDYPLEA VRMQNLIARE AEAAIYHLQL FEELRRLAPI TSDPTEATAV GAVEASFKCC SGAIIVLTKS GRSAHQVARY RPRAPIIAVT RNPQTARQAH LYRGIFPVLC KDPVQEAWAE DVDLRVNFAM NVGKARGFFK KGDVVIVLTG WRPGSGFTNT MRVVPVP //