ID	1RO6A	STANDARD;	PRT;	378	AA.
DT	CONVERTED FROM PDB (SEQRES) 1RO6
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.000
CC	R-Factor	0.218
FT	#SUB	15	 165 	HIS	A	345	 495 	GLN	B	Protein	S	3
FT	#SUB	18	 168 	LYS	A	344	 494 	GLU	B	Protein	S	3
FT	#SUB	19	 169 	GLU	A	344	 494 	GLU	B	Protein	S	3
FT	#SUB	29	 179 	ASN	A	342	 492 	LEU	B	Protein	S	1
FT	#SUB	32	 182 	ASN	A	342	 492 	LEU	B	Protein	S	4
FT	#SUB	32	 182 	ASN	A	343	 493 	ASP	B	Protein	S	5
FT	#SUB	32	 182 	ASN	A	344	 494 	GLU	B	Protein	S	4
FT	#SUB	36	 186 	TYR	A	343	 493 	ASP	B	Protein	S	2
FT	#SUB	36	 186 	TYR	A	345	 495 	GLN	B	Protein	S	1
FT	#SUB	249	 399 	SER	A	329	 479 	TRP	B	Protein	S	1
FT	#SUB	250	 400 	LEU	A	332	 482 	SER	B	Protein	S	2
FT	#SUB	250	 400 	LEU	A	333	 483 	MET	B	Protein	S	2
FT	#SUB	251	 401 	GLU	A	332	 482 	SER	B	Protein	A	6
FT	#SUB	251	 401 	GLU	A	341	 491 	PRO	B	Protein	S	5
FT	#SUB	254	 404 	ARG	A	331	 481 	GLN	B	Protein	S	1
FT	#SUB	254	 404 	ARG	A	332	 482 	SER	B	Protein	S	5
FT	#SUB	254	 404 	ARG	A	334	 484 	ILE	B	Protein	S	5
FT	#SUB	255	 405 	GLN	A	340	 490 	PRO	B	Protein	S	3
FT	#SUB	255	 405 	GLN	A	341	 491 	PRO	B	Protein	S	1
FT	#SUB	258	 408 	ASP	A	338	 488 	PRO	B	Protein	S	3
FT	#SUB	258	 408 	ASP	A	340	 490 	PRO	B	Protein	S	2
FT	#SUB	329	 479 	TRP	A	333	 483 	MET	B	Protein	S	9
FT	#SUB	333	 483 	MET	A	335	 485 	PRO	B	Protein	S	3
FT	#SUB	340	 490 	PRO	A	285	 435 	HIS	B	Protein	S	1
FT	#SUB	341	 491 	PRO	A	285	 435 	HIS	B	Protein	S	2
FT	#SUB	342	 492 	LEU	A	288	 438 	SER	B	Protein	S	6
FT	#SUB	342	 492 	LEU	A	290	 440 	GLU	B	Protein	A	12
FT	#SUB	342	 492 	LEU	A	333	 483 	MET	B	Protein	S	2
FT	#SUB	342	 492 	LEU	A	335	 485 	PRO	B	Protein	S	1
FT	#SUB	343	 493 	ASP	A	290	 440 	GLU	B	Protein	S	5
FT	#HET	44	 194 	CYS	A	3	531 	ARS	A	A	4
FT	#HET	83	 233 	TYR	A	4	601 	ROL	A	S	24
FT	#HET	84	 234 	HIS	A	2	530 	MN	A	S	1
FT	#HET	84	 234 	HIS	A	4	601 	ROL	A	S	13
FT	#HET	88	 238 	HIS	A	1	529 	ZN	A	S	3
FT	#HET	88	 238 	HIS	A	4	601 	ROL	A	S	1
FT	#HET	124	 274 	HIS	A	1	529 	ZN	A	S	3
FT	#HET	125	 275 	ASP	A	1	529 	ZN	A	S	3
FT	#HET	125	 275 	ASP	A	2	530 	MN	A	S	3
FT	#HET	197	 347 	MET	A	4	601 	ROL	A	S	9
FT	#HET	242	 392 	ASP	A	1	529 	ZN	A	S	3
FT	#HET	242	 392 	ASP	A	4	601 	ROL	A	A	7
FT	#HET	243	 393 	LEU	A	4	601 	ROL	A	S	8
FT	#HET	245	 395 	ASN	A	4	601 	ROL	A	S	18
FT	#HET	246	 396 	PRO	A	4	601 	ROL	A	S	2
FT	#HET	253	 403 	TYR	A	4	601 	ROL	A	S	8
FT	#HET	256	 406 	TRP	A	4	601 	ROL	A	A	7
FT	#HET	257	 407 	THR	A	4	601 	ROL	A	A	20
FT	#HET	260	 410 	ILE	A	4	601 	ROL	A	S	22
FT	#HET	261	 411 	MET	A	4	601 	ROL	A	S	6
FT	#HET	264	 414 	PHE	A	4	601 	ROL	A	S	28
FT	#HET	281	 431 	MET	A	4	601 	ROL	A	S	10
FT	#HET	292	 442 	SER	A	4	601 	ROL	A	A	18
FT	#HET	293	 443 	GLN	A	4	601 	ROL	A	S	35
FT	#HET	296	 446 	PHE	A	4	601 	ROL	A	S	55
FT	DISORDER	1	1
FT	DISORDER	346	378
CC	SEQUENCE	344 AA (ATOM);
CC	SISRFGVNTE NEDHLAKELE DLNKWGLNIF NVAGYSHNRP LTCIMYAIFQ ERDLLKTFRI
CC	SSDTFITYMM TLEDHYHSDV AYHNSLHAAD VAQSTHVLLS TPALDAVFTD LEILAAIFAA
CC	AIHDVDHPGV SNQFLINTNS ELALMYNDES VLENHHLAVG FKLLQEEHCD IFMNLTKKQR
CC	QTLRKMVIDM VLATDMSKHM SLLADLKTMV ETKKVTSSGV LLLDNYTDRI QVLRNMVHCA
CC	DLSNPTKSLE LYRQWTDRIM EEFFQQGDKE RERGMEISPM CDKHTASVEK SQVGFIDYIV
CC	HPLWETWADL VQPDAQDILD TLEDNRNWYQ SMIPQAPAPP LDEQ
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIF
CC	ATOM   -SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIF
CC	        *************************************************
CC	SEQRES QERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
CC	ATOM   QERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
CC	       **************************************************
CC	SEQRES STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
CC	ATOM   STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
CC	       **************************************************
CC	SEQRES SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKH
CC	ATOM   SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKH
CC	       **************************************************
CC	SEQRES MSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL
CC	ATOM   MSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL
CC	       **************************************************
CC	SEQRES ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYI
CC	ATOM   ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYI
CC	       **************************************************
CC	SEQRES VHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQAPAPPLDEQNRDCQ
CC	ATOM   VHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQAPAPPLDEQ-----
CC	       *********************************************     
CC	SEQRES GLMEKFQFELTLDEEDSEGPEKEGEGHS
CC	ATOM   ----------------------------
CC	                                   
SQ	SEQUENCE	378 AA;      MW;         CN;
	MSISRFGVNT ENEDHLAKEL EDLNKWGLNI FNVAGYSHNR PLTCIMYAIF QERDLLKTFR
	ISSDTFITYM MTLEDHYHSD VAYHNSLHAA DVAQSTHVLL STPALDAVFT DLEILAAIFA
	AAIHDVDHPG VSNQFLINTN SELALMYNDE SVLENHHLAV GFKLLQEEHC DIFMNLTKKQ
	RQTLRKMVID MVLATDMSKH MSLLADLKTM VETKKVTSSG VLLLDNYTDR IQVLRNMVHC
	ADLSNPTKSL ELYRQWTDRI MEEFFQQGDK ERERGMEISP MCDKHTASVE KSQVGFIDYI
	VHPLWETWAD LVQPDAQDIL DTLEDNRNWY QSMIPQAPAP PLDEQNRDCQ GLMEKFQFEL
	TLDEEDSEGP EKEGEGHS
//
ID	1RO6B	STANDARD;	PRT;	378	AA.
DT	CONVERTED FROM PDB (SEQRES) 1RO6
DE	cAMP-specific 3',5'-cyclic phosphodiesterase 4B
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.000
CC	R-Factor	0.218
FT	#SUB	285	 435 	HIS	B	340	 490 	PRO	A	Protein	S	1
FT	#SUB	285	 435 	HIS	B	341	 491 	PRO	A	Protein	B	2
FT	#SUB	288	 438 	SER	B	342	 492 	LEU	A	Protein	S	6
FT	#SUB	290	 440 	GLU	B	342	 492 	LEU	A	Protein	S	12
FT	#SUB	290	 440 	GLU	B	343	 493 	ASP	A	Protein	S	5
FT	#SUB	329	 479 	TRP	B	249	 399 	SER	A	Protein	S	1
FT	#SUB	331	 481 	GLN	B	254	 404 	ARG	A	Protein	B	1
FT	#SUB	332	 482 	SER	B	250	 400 	LEU	A	Protein	B	2
FT	#SUB	332	 482 	SER	B	251	 401 	GLU	A	Protein	S	6
FT	#SUB	332	 482 	SER	B	254	 404 	ARG	A	Protein	B	5
FT	#SUB	333	 483 	MET	B	250	 400 	LEU	A	Protein	A	2
FT	#SUB	333	 483 	MET	B	329	 479 	TRP	A	Protein	A	9
FT	#SUB	333	 483 	MET	B	342	 492 	LEU	A	Protein	B	2
FT	#SUB	334	 484 	ILE	B	254	 404 	ARG	A	Protein	B	5
FT	#SUB	335	 485 	PRO	B	333	 483 	MET	A	Protein	S	3
FT	#SUB	335	 485 	PRO	B	342	 492 	LEU	A	Protein	S	1
FT	#SUB	338	 488 	PRO	B	258	 408 	ASP	A	Protein	S	3
FT	#SUB	340	 490 	PRO	B	255	 405 	GLN	A	Protein	S	3
FT	#SUB	340	 490 	PRO	B	258	 408 	ASP	A	Protein	S	2
FT	#SUB	341	 491 	PRO	B	251	 401 	GLU	A	Protein	A	5
FT	#SUB	341	 491 	PRO	B	255	 405 	GLN	A	Protein	B	1
FT	#SUB	342	 492 	LEU	B	29	 179 	ASN	A	Protein	B	1
FT	#SUB	342	 492 	LEU	B	32	 182 	ASN	A	Protein	A	4
FT	#SUB	343	 493 	ASP	B	32	 182 	ASN	A	Protein	A	5
FT	#SUB	343	 493 	ASP	B	36	 186 	TYR	A	Protein	S	2
FT	#SUB	344	 494 	GLU	B	18	 168 	LYS	A	Protein	S	3
FT	#SUB	344	 494 	GLU	B	19	 169 	GLU	A	Protein	S	3
FT	#SUB	344	 494 	GLU	B	32	 182 	ASN	A	Protein	A	4
FT	#SUB	345	 495 	GLN	B	15	 165 	HIS	A	Protein	S	3
FT	#SUB	345	 495 	GLN	B	36	 186 	TYR	A	Protein	S	1
FT	#HET	83	 233 	TYR	B	7	602 	ROL	B	S	27
FT	#HET	84	 234 	HIS	B	7	602 	ROL	B	S	13
FT	#HET	88	 238 	HIS	B	5	529 	ZN	B	S	3
FT	#HET	88	 238 	HIS	B	7	602 	ROL	B	S	1
FT	#HET	124	 274 	HIS	B	5	529 	ZN	B	S	3
FT	#HET	124	 274 	HIS	B	6	530 	MN	B	A	2
FT	#HET	125	 275 	ASP	B	5	529 	ZN	B	S	3
FT	#HET	125	 275 	ASP	B	6	530 	MN	B	S	2
FT	#HET	125	 275 	ASP	B	7	602 	ROL	B	S	1
FT	#HET	154	 304 	GLU	B	6	530 	MN	B	S	2
FT	#HET	157	 307 	HIS	B	6	530 	MN	B	S	2
FT	#HET	195	 345 	THR	B	6	530 	MN	B	S	2
FT	#HET	197	 347 	MET	B	7	602 	ROL	B	S	8
FT	#HET	242	 392 	ASP	B	5	529 	ZN	B	S	3
FT	#HET	242	 392 	ASP	B	7	602 	ROL	B	A	14
FT	#HET	243	 393 	LEU	B	7	602 	ROL	B	S	9
FT	#HET	245	 395 	ASN	B	7	602 	ROL	B	S	17
FT	#HET	253	 403 	TYR	B	7	602 	ROL	B	S	7
FT	#HET	256	 406 	TRP	B	7	602 	ROL	B	A	6
FT	#HET	257	 407 	THR	B	7	602 	ROL	B	A	22
FT	#HET	260	 410 	ILE	B	7	602 	ROL	B	S	24
FT	#HET	261	 411 	MET	B	7	602 	ROL	B	S	4
FT	#HET	264	 414 	PHE	B	7	602 	ROL	B	S	20
FT	#HET	281	 431 	MET	B	7	602 	ROL	B	S	8
FT	#HET	292	 442 	SER	B	7	602 	ROL	B	A	29
FT	#HET	293	 443 	GLN	B	7	602 	ROL	B	A	38
FT	#HET	296	 446 	PHE	B	7	602 	ROL	B	A	46
FT	DISORDER	1	1
FT	DISORDER	346	378
CC	SEQUENCE	344 AA (ATOM);
CC	SISRFGVNTE NEDHLAKELE DLNKWGLNIF NVAGYSHNRP LTCIMYAIFQ ERDLLKTFRI
CC	SSDTFITYMM TLEDHYHSDV AYHNSLHAAD VAQSTHVLLS TPALDAVFTD LEILAAIFAA
CC	AIHDVDHPGV SNQFLINTNS ELALMYNDES VLENHHLAVG FKLLQEEHCD IFMNLTKKQR
CC	QTLRKMVIDM VLATDMSKHM SLLADLKTMV ETKKVTSSGV LLLDNYTDRI QVLRNMVHCA
CC	DLSNPTKSLE LYRQWTDRIM EEFFQQGDKE RERGMEISPM CDKHTASVEK SQVGFIDYIV
CC	HPLWETWADL VQPDAQDILD TLEDNRNWYQ SMIPQAPAPP LDEQ
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIF
CC	ATOM   -SISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIF
CC	        *************************************************
CC	SEQRES QERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
CC	ATOM   QERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLL
CC	       **************************************************
CC	SEQRES STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
CC	ATOM   STPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
CC	       **************************************************
CC	SEQRES SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKH
CC	ATOM   SVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKH
CC	       **************************************************
CC	SEQRES MSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL
CC	ATOM   MSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSL
CC	       **************************************************
CC	SEQRES ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYI
CC	ATOM   ELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYI
CC	       **************************************************
CC	SEQRES VHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQAPAPPLDEQNRDCQ
CC	ATOM   VHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQAPAPPLDEQ-----
CC	       *********************************************     
CC	SEQRES GLMEKFQFELTLDEEDSEGPEKEGEGHS
CC	ATOM   ----------------------------
CC	                                   
SQ	SEQUENCE	378 AA;      MW;         CN;
	MSISRFGVNT ENEDHLAKEL EDLNKWGLNI FNVAGYSHNR PLTCIMYAIF QERDLLKTFR
	ISSDTFITYM MTLEDHYHSD VAYHNSLHAA DVAQSTHVLL STPALDAVFT DLEILAAIFA
	AAIHDVDHPG VSNQFLINTN SELALMYNDE SVLENHHLAV GFKLLQEEHC DIFMNLTKKQ
	RQTLRKMVID MVLATDMSKH MSLLADLKTM VETKKVTSSG VLLLDNYTDR IQVLRNMVHC
	ADLSNPTKSL ELYRQWTDRI MEEFFQQGDK ERERGMEISP MCDKHTASVE KSQVGFIDYI
	VHPLWETWAD LVQPDAQDIL DTLEDNRNWY QSMIPQAPAP PLDEQNRDCQ GLMEKFQFEL
	TLDEEDSEGP EKEGEGHS
//