ID 1F8IA STANDARD; PRT; 429 AA. DT CONVERTED FROM PDB (SEQRES) 1F8I DE ISOCITRATE LYASE OS Mycobacterium tuberculosis H37Rv CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.250 CC R-Factor 0.166 FT #SUB 66 65 TRP A 370 369 GLN B Protein S 2 FT #SUB 68 67 ASN A 366 365 TYR B Protein S 9 FT #SUB 68 67 ASN A 370 369 GLN B Protein S 1 FT #SUB 69 68 ALA A 366 365 TYR B Protein B 7 FT #SUB 70 69 LEU A 363 362 ALA B Protein S 3 FT #SUB 70 69 LEU A 366 365 TYR B Protein S 9 FT #SUB 74 73 THR A 99 98 ASP B Protein A 8 FT #SUB 74 73 THR A 355 354 LEU B Protein S 3 FT #SUB 75 74 GLY A 99 98 ASP B Protein B 3 FT #SUB 76 75 ASN A 98 97 GLY B Protein S 1 FT #SUB 76 75 ASN A 99 98 ASP B Protein A 17 FT #SUB 76 75 ASN A 352 351 PHE B Protein S 2 FT #SUB 76 75 ASN A 355 354 LEU B Protein S 1 FT #SUB 76 75 ASN A 356 355 ASN B Protein A 9 FT #SUB 77 76 MET A 355 354 LEU B Protein A 2 FT #SUB 77 76 MET A 359 358 MET B Protein A 2 FT #SUB 80 79 GLN A 356 355 ASN B Protein S 10 FT #SUB 80 79 GLN A 360 359 PHE B Protein S 5 FT #SUB 81 80 GLN A 359 358 MET B Protein S 5 FT #SUB 81 80 GLN A 363 362 ALA B Protein B 1 FT #SUB 83 82 ARG A 360 359 PHE B Protein S 2 FT #SUB 84 83 ALA A 360 359 PHE B Protein A 2 FT #SUB 84 83 ALA A 363 362 ALA B Protein S 2 FT #SUB 84 83 ALA A 364 363 TYR B Protein S 2 FT #SUB 84 83 ALA A 367 366 ALA B Protein B 1 FT #SUB 86 85 LEU A 366 365 TYR B Protein S 2 FT #SUB 94 93 TRP A 394 393 HIS B Protein S 7 FT #SUB 94 93 TRP A 395 394 GLN B Protein S 4 FT #SUB 94 93 TRP A 398 397 VAL B Protein S 1 FT #SUB 98 97 GLY A 76 75 ASN B Protein B 1 FT #SUB 98 97 GLY A 124 123 ARG B Protein B 1 FT #SUB 98 97 GLY A 398 397 VAL B Protein B 1 FT #SUB 99 98 ASP A 74 73 THR B Protein S 8 FT #SUB 99 98 ASP A 75 74 GLY B Protein S 4 FT #SUB 99 98 ASP A 76 75 ASN B Protein S 17 FT #SUB 99 98 ASP A 124 123 ARG B Protein A 5 FT #SUB 104 103 GLY A 124 123 ARG B Protein B 8 FT #SUB 104 103 GLY A 127 126 ASN B Protein B 5 FT #SUB 105 104 HIS A 124 123 ARG B Protein B 3 FT #SUB 105 104 HIS A 127 126 ASN B Protein A 9 FT #SUB 106 105 THR A 124 123 ARG B Protein A 6 FT #SUB 106 105 THR A 128 127 ALA B Protein S 2 FT #SUB 106 105 THR A 131 130 ARG B Protein B 3 FT #SUB 106 105 THR A 398 397 VAL B Protein S 3 FT #SUB 107 106 TYR A 131 130 ARG B Protein S 2 FT #SUB 107 106 TYR A 398 397 VAL B Protein B 8 FT #SUB 107 106 TYR A 403 402 PHE B Protein S 2 FT #SUB 108 107 PRO A 398 397 VAL B Protein A 3 FT #SUB 108 107 PRO A 400 399 ALA B Protein S 2 FT #SUB 108 107 PRO A 403 402 PHE B Protein S 5 FT #SUB 110 109 GLN A 418 417 ALA B Protein S 1 FT #SUB 112 111 LEU A 403 402 PHE B Protein S 2 FT #SUB 124 123 ARG A 98 97 GLY B Protein S 1 FT #SUB 124 123 ARG A 99 98 ASP B Protein S 5 FT #SUB 124 123 ARG A 104 103 GLY B Protein A 8 FT #SUB 124 123 ARG A 105 104 HIS B Protein S 3 FT #SUB 124 123 ARG A 106 105 THR B Protein S 6 FT #SUB 127 126 ASN A 104 103 GLY B Protein S 5 FT #SUB 127 126 ASN A 105 104 HIS B Protein S 7 FT #SUB 128 127 ALA A 106 105 THR B Protein A 2 FT #SUB 131 130 ARG A 105 104 HIS B Protein S 1 FT #SUB 131 130 ARG A 106 105 THR B Protein S 5 FT #SUB 131 130 ARG A 107 106 TYR B Protein S 2 FT #SUB 189 188 GLU A 416 415 THR B Protein S 4 FT #SUB 191 190 LYS A 416 415 THR B Protein S 5 FT #SUB 192 191 SER A 395 394 GLN B Protein S 1 FT #SUB 194 193 HIS A 422 421 SER B Protein B 3 FT #SUB 194 193 HIS A 423 422 THR B Protein A 4 FT #SUB 195 194 LEU A 395 394 GLN B Protein S 7 FT #SUB 195 194 LEU A 418 417 ALA B Protein A 5 FT #SUB 195 194 LEU A 422 421 SER B Protein A 2 FT #SUB 196 195 GLY A 417 416 THR B Protein B 2 FT #SUB 196 195 GLY A 418 417 ALA B Protein B 6 FT #SUB 196 195 GLY A 420 419 THR B Protein B 1 FT #SUB 196 195 GLY A 422 421 SER B Protein B 3 FT #SUB 197 196 GLY A 416 415 THR B Protein B 2 FT #SUB 197 196 GLY A 417 416 THR B Protein B 2 FT #SUB 199 198 VAL A 416 415 THR B Protein S 1 FT #SUB 237 236 LEU A 415 414 SER B Protein S 2 FT #SUB 255 254 THR A 415 414 SER B Protein S 3 FT #SUB 256 255 ARG A 413 412 ASN B Protein S 1 FT #SUB 257 256 GLU A 414 413 SER B Protein S 2 FT #SUB 257 256 GLU A 415 414 SER B Protein S 8 FT #SUB 259 258 PHE A 416 415 THR B Protein S 1 FT #SUB 288 287 GLY A 423 422 THR B Protein B 1 FT #SUB 288 287 GLY A 427 426 GLN B Protein B 1 FT #SUB 315 314 CYS A 371 370 MET B Protein S 3 FT #SUB 317 316 PRO A 374 373 TYR B Protein S 5 FT #SUB 317 316 PRO A 378 377 GLN B Protein B 1 FT #SUB 317 316 PRO A 394 393 HIS B Protein B 2 FT #SUB 317 316 PRO A 428 427 PHE B Protein B 1 FT #SUB 318 317 SER A 394 393 HIS B Protein A 6 FT #SUB 318 317 SER A 395 394 GLN B Protein S 1 FT #SUB 318 317 SER A 423 422 THR B Protein A 4 FT #SUB 318 317 SER A 428 427 PHE B Protein B 2 FT #SUB 319 318 PHE A 378 377 GLN B Protein B 4 FT #SUB 319 318 PHE A 427 426 GLN B Protein B 2 FT #SUB 320 319 ASN A 378 377 GLN B Protein B 1 FT #SUB 320 319 ASN A 382 381 PHE B Protein S 4 FT #SUB 320 319 ASN A 427 426 GLN B Protein A 4 FT #SUB 320 319 ASN A 428 427 PHE B Protein B 1 FT #SUB 321 320 TRP A 371 370 MET B Protein S 3 FT #SUB 321 320 TRP A 375 374 VAL B Protein S 1 FT #SUB 321 320 TRP A 378 377 GLN B Protein A 5 FT #SUB 322 321 LYS A 375 374 VAL B Protein S 2 FT #SUB 322 321 LYS A 379 378 GLU B Protein S 5 FT #SUB 323 322 LYS A 426 425 GLY B Protein S 1 FT #SUB 323 322 LYS A 427 426 GLN B Protein S 3 FT #SUB 324 323 HIS A 427 426 GLN B Protein S 5 FT #SUB 330 329 ILE A 371 370 MET B Protein A 4 FT #SUB 330 329 ILE A 372 371 SER B Protein S 2 FT #SUB 330 329 ILE A 375 374 VAL B Protein S 1 FT #SUB 331 330 ALA A 372 371 SER B Protein A 3 FT #SUB 334 333 GLN A 366 365 TYR B Protein S 5 FT #SUB 334 333 GLN A 370 369 GLN B Protein S 6 FT #SUB 334 333 GLN A 371 370 MET B Protein S 2 FT #SUB 345 344 GLN A 366 365 TYR B Protein B 1 FT #SUB 347 346 ILE A 366 365 TYR B Protein S 2 FT #SUB 347 346 ILE A 371 370 MET B Protein S 2 FT #SUB 347 346 ILE A 374 373 TYR B Protein S 4 FT #SUB 349 348 LEU A 394 393 HIS B Protein S 5 FT #SUB 350 349 ALA A 359 358 MET B Protein B 1 FT #SUB 350 349 ALA A 362 361 LEU B Protein S 1 FT #SUB 351 350 GLY A 359 358 MET B Protein B 1 FT #SUB 352 351 PHE A 76 75 ASN B Protein S 2 FT #SUB 352 351 PHE A 391 390 ALA B Protein S 1 FT #SUB 352 351 PHE A 394 393 HIS B Protein S 3 FT #SUB 352 351 PHE A 397 396 GLU B Protein S 1 FT #SUB 353 352 HIS A 374 373 TYR B Protein S 3 FT #SUB 353 352 HIS A 381 380 GLU B Protein A 13 FT #SUB 353 352 HIS A 391 390 ALA B Protein S 2 FT #SUB 353 352 HIS A 392 391 THR B Protein S 1 FT #SUB 353 352 HIS A 394 393 HIS B Protein S 5 FT #SUB 354 353 ALA A 358 357 SER B Protein B 3 FT #SUB 354 353 ALA A 359 358 MET B Protein S 1 FT #SUB 354 353 ALA A 377 376 LEU B Protein B 1 FT #SUB 355 354 LEU A 74 73 THR B Protein S 2 FT #SUB 355 354 LEU A 77 76 MET B Protein S 1 FT #SUB 356 355 ASN A 76 75 ASN B Protein S 9 FT #SUB 356 355 ASN A 80 79 GLN B Protein A 10 FT #SUB 356 355 ASN A 389 388 TYR B Protein A 4 FT #SUB 356 355 ASN A 391 390 ALA B Protein S 1 FT #SUB 357 356 TYR A 377 376 LEU B Protein S 1 FT #SUB 357 356 TYR A 380 379 ARG B Protein S 4 FT #SUB 357 356 TYR A 381 380 GLU B Protein S 1 FT #SUB 357 356 TYR A 384 383 ALA B Protein S 1 FT #SUB 357 356 TYR A 387 386 ARG B Protein S 1 FT #SUB 357 356 TYR A 389 388 TYR B Protein A 7 FT #SUB 358 357 SER A 354 353 ALA B Protein S 4 FT #SUB 358 357 SER A 358 357 SER B Protein S 4 FT #SUB 359 358 MET A 77 76 MET B Protein S 1 FT #SUB 359 358 MET A 81 80 GLN B Protein S 4 FT #SUB 359 358 MET A 351 350 GLY B Protein S 2 FT #SUB 360 359 PHE A 80 79 GLN B Protein A 5 FT #SUB 360 359 PHE A 83 82 ARG B Protein S 1 FT #SUB 360 359 PHE A 387 386 ARG B Protein S 4 FT #SUB 360 359 PHE A 389 388 TYR B Protein S 10 FT #SUB 361 360 ASP A 387 386 ARG B Protein S 3 FT #SUB 362 361 LEU A 350 349 ALA B Protein S 1 FT #SUB 363 362 ALA A 70 69 LEU B Protein A 3 FT #SUB 363 362 ALA A 81 80 GLN B Protein S 1 FT #SUB 363 362 ALA A 84 83 ALA B Protein A 2 FT #SUB 363 362 ALA A 86 85 LEU B Protein S 1 FT #SUB 364 363 TYR A 84 83 ALA B Protein B 2 FT #SUB 364 363 TYR A 387 386 ARG B Protein S 7 FT #SUB 366 365 TYR A 68 67 ASN B Protein S 6 FT #SUB 366 365 TYR A 69 68 ALA B Protein S 7 FT #SUB 366 365 TYR A 70 69 LEU B Protein S 9 FT #SUB 366 365 TYR A 86 85 LEU B Protein S 2 FT #SUB 366 365 TYR A 334 333 GLN B Protein S 5 FT #SUB 366 365 TYR A 345 344 GLN B Protein S 1 FT #SUB 366 365 TYR A 347 346 ILE B Protein S 3 FT #SUB 367 366 ALA A 84 83 ALA B Protein S 1 FT #SUB 370 369 GLN A 66 65 TRP B Protein S 2 FT #SUB 370 369 GLN A 68 67 ASN B Protein S 1 FT #SUB 370 369 GLN A 334 333 GLN B Protein S 6 FT #SUB 371 370 MET A 315 314 CYS B Protein S 3 FT #SUB 371 370 MET A 321 320 TRP B Protein S 3 FT #SUB 371 370 MET A 330 329 ILE B Protein A 3 FT #SUB 371 370 MET A 334 333 GLN B Protein S 2 FT #SUB 371 370 MET A 347 346 ILE B Protein S 2 FT #SUB 372 371 SER A 330 329 ILE B Protein A 3 FT #SUB 372 371 SER A 331 330 ALA B Protein S 3 FT #SUB 374 373 TYR A 317 316 PRO B Protein S 6 FT #SUB 374 373 TYR A 347 346 ILE B Protein S 3 FT #SUB 374 373 TYR A 350 349 ALA B Protein S 1 FT #SUB 374 373 TYR A 353 352 HIS B Protein S 4 FT #SUB 375 374 VAL A 321 320 TRP B Protein S 1 FT #SUB 375 374 VAL A 322 321 LYS B Protein S 2 FT #SUB 375 374 VAL A 330 329 ILE B Protein S 2 FT #SUB 377 376 LEU A 357 356 TYR B Protein S 1 FT #SUB 378 377 GLN A 317 316 PRO B Protein S 1 FT #SUB 378 377 GLN A 319 318 PHE B Protein S 4 FT #SUB 378 377 GLN A 321 320 TRP B Protein S 5 FT #SUB 379 378 GLU A 322 321 LYS B Protein S 5 FT #SUB 380 379 ARG A 357 356 TYR B Protein A 3 FT #SUB 381 380 GLU A 353 352 HIS B Protein S 12 FT #SUB 381 380 GLU A 357 356 TYR B Protein S 2 FT #SUB 382 381 PHE A 320 319 ASN B Protein S 5 FT #SUB 384 383 ALA A 357 356 TYR B Protein S 1 FT #SUB 387 386 ARG A 357 356 TYR B Protein S 1 FT #SUB 387 386 ARG A 360 359 PHE B Protein B 1 FT #SUB 387 386 ARG A 361 360 ASP B Protein S 3 FT #SUB 387 386 ARG A 364 363 TYR B Protein A 6 FT #SUB 388 387 GLY A 360 359 PHE B Protein B 1 FT #SUB 389 388 TYR A 356 355 ASN B Protein S 4 FT #SUB 389 388 TYR A 357 356 TYR B Protein S 5 FT #SUB 389 388 TYR A 360 359 PHE B Protein A 10 FT #SUB 391 390 ALA A 352 351 PHE B Protein B 1 FT #SUB 391 390 ALA A 353 352 HIS B Protein B 2 FT #SUB 391 390 ALA A 356 355 ASN B Protein S 1 FT #SUB 392 391 THR A 353 352 HIS B Protein B 1 FT #SUB 394 393 HIS A 94 93 TRP B Protein A 8 FT #SUB 394 393 HIS A 317 316 PRO B Protein S 2 FT #SUB 394 393 HIS A 318 317 SER B Protein S 7 FT #SUB 394 393 HIS A 349 348 LEU B Protein S 5 FT #SUB 394 393 HIS A 352 351 PHE B Protein S 1 FT #SUB 394 393 HIS A 353 352 HIS B Protein S 4 FT #SUB 395 394 GLN A 94 93 TRP B Protein S 4 FT #SUB 395 394 GLN A 192 191 SER B Protein S 1 FT #SUB 395 394 GLN A 195 194 LEU B Protein S 7 FT #SUB 395 394 GLN A 318 317 SER B Protein S 1 FT #SUB 397 396 GLU A 352 351 PHE B Protein S 1 FT #SUB 398 397 VAL A 94 93 TRP B Protein S 1 FT #SUB 398 397 VAL A 98 97 GLY B Protein S 1 FT #SUB 398 397 VAL A 106 105 THR B Protein A 4 FT #SUB 398 397 VAL A 107 106 TYR B Protein A 7 FT #SUB 398 397 VAL A 108 107 PRO B Protein A 4 FT #SUB 400 399 ALA A 108 107 PRO B Protein B 2 FT #SUB 403 402 PHE A 107 106 TYR B Protein S 2 FT #SUB 403 402 PHE A 108 107 PRO B Protein S 4 FT #SUB 403 402 PHE A 112 111 LEU B Protein S 2 FT #SUB 413 412 ASN A 256 255 ARG B Protein S 1 FT #SUB 414 413 SER A 257 256 GLU B Protein B 2 FT #SUB 415 414 SER A 237 236 LEU B Protein B 1 FT #SUB 415 414 SER A 255 254 THR B Protein S 2 FT #SUB 415 414 SER A 257 256 GLU B Protein A 6 FT #SUB 416 415 THR A 189 188 GLU B Protein S 4 FT #SUB 416 415 THR A 191 190 LYS B Protein A 5 FT #SUB 416 415 THR A 197 196 GLY B Protein A 2 FT #SUB 416 415 THR A 199 198 VAL B Protein S 1 FT #SUB 416 415 THR A 259 258 PHE B Protein S 1 FT #SUB 417 416 THR A 191 190 LYS B Protein B 2 FT #SUB 417 416 THR A 196 195 GLY B Protein B 2 FT #SUB 417 416 THR A 197 196 GLY B Protein B 2 FT #SUB 418 417 ALA A 110 109 GLN B Protein S 1 FT #SUB 418 417 ALA A 195 194 LEU B Protein A 4 FT #SUB 418 417 ALA A 196 195 GLY B Protein B 6 FT #SUB 420 419 THR A 196 195 GLY B Protein B 2 FT #SUB 422 421 SER A 194 193 HIS B Protein A 3 FT #SUB 422 421 SER A 195 194 LEU B Protein S 2 FT #SUB 423 422 THR A 194 193 HIS B Protein A 6 FT #SUB 423 422 THR A 288 287 GLY B Protein S 1 FT #SUB 423 422 THR A 318 317 SER B Protein S 4 FT #SUB 426 425 GLY A 323 322 LYS B Protein B 1 FT #SUB 427 426 GLN A 288 287 GLY B Protein S 1 FT #SUB 427 426 GLN A 289 288 THR B Protein S 1 FT #SUB 427 426 GLN A 318 317 SER B Protein S 1 FT #SUB 427 426 GLN A 319 318 PHE B Protein S 2 FT #SUB 427 426 GLN A 320 319 ASN B Protein A 4 FT #SUB 427 426 GLN A 323 322 LYS B Protein B 4 FT #SUB 427 426 GLN A 324 323 HIS B Protein S 6 FT #SUB 428 427 PHE A 317 316 PRO B Protein S 1 FT #SUB 428 427 PHE A 318 317 SER B Protein S 2 FT #SUB 428 427 PHE A 319 318 PHE B Protein S 1 FT #SUB 102 101 LEU A 116 115 ASN C Protein B 1 FT #SUB 107 106 TYR A 167 166 GLU C Protein S 11 FT #SUB 110 109 GLN A 163 162 LEU C Protein S 1 FT #SUB 111 110 SER A 164 163 ASN C Protein B 1 FT #SUB 112 111 LEU A 163 162 LEU C Protein S 1 FT #SUB 112 111 LEU A 164 163 ASN C Protein B 1 FT #SUB 114 113 PRO A 116 115 ASN C Protein S 5 FT #SUB 116 115 ASN A 102 101 LEU C Protein S 1 FT #SUB 116 115 ASN A 114 113 PRO C Protein S 4 FT #SUB 160 159 GLY A 188 187 SER C Protein B 5 FT #SUB 161 160 GLY A 188 187 SER C Protein B 5 FT #SUB 163 162 LEU A 110 109 GLN C Protein S 1 FT #SUB 163 162 LEU A 112 111 LEU C Protein A 2 FT #SUB 164 163 ASN A 111 110 SER C Protein S 2 FT #SUB 164 163 ASN A 112 111 LEU C Protein S 2 FT #SUB 164 163 ASN A 188 187 SER C Protein S 1 FT #SUB 167 166 GLU A 107 106 TYR C Protein S 11 FT #SUB 188 187 SER A 160 159 GLY C Protein A 4 FT #SUB 188 187 SER A 161 160 GLY C Protein A 4 FT #SUB 188 187 SER A 164 163 ASN C Protein B 1 FT #SUB 208 207 ARG A 257 256 GLU C Protein S 1 FT #SUB 240 239 SER A 254 253 ARG C Protein S 1 FT #SUB 241 240 ASP A 254 253 ARG C Protein S 1 FT #SUB 242 241 VAL A 256 255 ARG C Protein S 1 FT #SUB 242 241 VAL A 257 256 GLU C Protein S 1 FT #SUB 242 241 VAL A 258 257 GLY C Protein S 1 FT #SUB 254 253 ARG A 240 239 SER C Protein S 1 FT #SUB 254 253 ARG A 241 240 ASP C Protein S 1 FT #SUB 256 255 ARG A 242 241 VAL C Protein B 1 FT #SUB 257 256 GLU A 208 207 ARG C Protein S 1 FT #SUB 257 256 GLU A 242 241 VAL C Protein B 1 FT #SUB 258 257 GLY A 242 241 VAL C Protein B 2 FT #SUB 260 259 TYR A 260 259 TYR C Protein S 1 FT #SUB 2 1 ALA A 59 58 GLU D Protein B 2 FT #SUB 3 2 SER A 52 51 ARG D Protein A 3 FT #SUB 3 2 SER A 55 54 GLU D Protein S 1 FT #SUB 5 4 VAL A 51 50 ARG D Protein S 1 FT #SUB 5 4 VAL A 52 51 ARG D Protein A 4 FT #SUB 5 4 VAL A 55 54 GLU D Protein S 3 FT #SUB 6 5 GLY A 48 47 THR D Protein B 1 FT #SUB 31 30 TYR A 409 408 THR D Protein S 2 FT #SUB 35 34 ASP A 409 408 THR D Protein S 1 FT #SUB 37 36 VAL A 137 136 LYS D Protein A 4 FT #SUB 38 37 ALA A 138 137 ILE D Protein B 1 FT #SUB 38 37 ALA A 405 404 ARG D Protein S 2 FT #SUB 39 38 LEU A 402 401 TYR D Protein A 7 FT #SUB 39 38 LEU A 405 404 ARG D Protein S 1 FT #SUB 39 38 LEU A 406 405 ILE D Protein S 1 FT #SUB 41 40 GLY A 133 132 ASP D Protein B 2 FT #SUB 41 40 GLY A 137 136 LYS D Protein B 8 FT #SUB 42 41 SER A 133 132 ASP D Protein A 9 FT #SUB 43 42 VAL A 52 51 ARG D Protein S 3 FT #SUB 43 42 VAL A 133 132 ASP D Protein B 1 FT #SUB 43 42 VAL A 148 147 LEU D Protein S 3 FT #SUB 44 43 VAL A 48 47 THR D Protein B 1 FT #SUB 45 44 GLU A 48 47 THR D Protein B 3 FT #SUB 45 44 GLU A 49 48 LEU D Protein S 5 FT #SUB 45 44 GLU A 123 122 ARG D Protein S 7 FT #SUB 45 44 GLU A 130 129 GLN D Protein S 5 FT #SUB 46 45 GLU A 46 45 GLU D Protein A 5 FT #SUB 46 45 GLU A 48 47 THR D Protein A 4 FT #SUB 48 47 THR A 5 4 VAL D Protein B 1 FT #SUB 48 47 THR A 6 5 GLY D Protein S 1 FT #SUB 48 47 THR A 44 43 VAL D Protein S 1 FT #SUB 48 47 THR A 45 44 GLU D Protein S 3 FT #SUB 48 47 THR A 46 45 GLU D Protein S 4 FT #SUB 49 48 LEU A 45 44 GLU D Protein S 5 FT #SUB 52 51 ARG A 3 2 SER D Protein S 4 FT #SUB 52 51 ARG A 5 4 VAL D Protein S 3 FT #SUB 52 51 ARG A 43 42 VAL D Protein S 1 FT #SUB 55 54 GLU A 3 2 SER D Protein S 1 FT #SUB 55 54 GLU A 5 4 VAL D Protein S 2 FT #SUB 56 55 VAL A 3 2 SER D Protein S 1 FT #SUB 59 58 GLU A 2 1 ALA D Protein S 2 FT #SUB 123 122 ARG A 45 44 GLU D Protein S 7 FT #SUB 130 129 GLN A 45 44 GLU D Protein S 5 FT #SUB 133 132 ASP A 41 40 GLY D Protein S 2 FT #SUB 133 132 ASP A 42 41 SER D Protein S 9 FT #SUB 133 132 ASP A 43 42 VAL D Protein S 1 FT #SUB 137 136 LYS A 37 36 VAL D Protein S 4 FT #SUB 137 136 LYS A 38 37 ALA D Protein S 1 FT #SUB 137 136 LYS A 41 40 GLY D Protein S 8 FT #SUB 138 137 ILE A 38 37 ALA D Protein S 1 FT #SUB 148 147 LEU A 43 42 VAL D Protein S 3 FT #SUB 163 162 LEU A 403 402 PHE D Protein S 1 FT #SUB 163 162 LEU A 406 405 ILE D Protein S 2 FT #SUB 166 165 TYR A 406 405 ILE D Protein S 3 FT #SUB 167 166 GLU A 403 402 PHE D Protein S 2 FT #SUB 208 207 ARG A 410 409 VAL D Protein B 1 FT #SUB 208 207 ARG A 411 410 ASP D Protein S 5 FT #SUB 212 211 SER A 410 409 VAL D Protein A 2 FT #SUB 215 214 LEU A 409 408 THR D Protein S 3 FT #SUB 215 214 LEU A 410 409 VAL D Protein S 1 FT #SUB 402 401 TYR A 39 38 LEU D Protein S 8 FT #SUB 403 402 PHE A 163 162 LEU D Protein B 1 FT #SUB 403 402 PHE A 167 166 GLU D Protein S 2 FT #SUB 405 404 ARG A 38 37 ALA D Protein S 2 FT #SUB 405 404 ARG A 39 38 LEU D Protein S 1 FT #SUB 406 405 ILE A 39 38 LEU D Protein S 1 FT #SUB 406 405 ILE A 163 162 LEU D Protein S 2 FT #SUB 406 405 ILE A 166 165 TYR D Protein S 3 FT #SUB 409 408 THR A 31 30 TYR D Protein A 2 FT #SUB 409 408 THR A 35 34 ASP D Protein S 1 FT #SUB 409 408 THR A 215 214 LEU D Protein S 2 FT #SUB 410 409 VAL A 208 207 ARG D Protein S 1 FT #SUB 410 409 VAL A 212 211 SER D Protein S 2 FT #SUB 410 409 VAL A 215 214 LEU D Protein S 1 FT #SUB 411 410 ASP A 208 207 ARG D Protein S 2 FT #HET 90 89 TYR A 2 461 GLV A S 5 FT #HET 92 91 SER A 2 461 GLV A A 6 FT #HET 93 92 GLY A 2 461 GLV A B 4 FT #HET 94 93 TRP A 2 461 GLV A A 6 FT #HET 94 93 TRP A 3 471 SIN A S 1 FT #HET 109 108 ASP A 1 451 MG A S 1 FT #HET 109 108 ASP A 2 461 GLV A S 1 FT #HET 109 108 ASP A 3 471 SIN A S 2 FT #HET 154 153 ASP A 1 451 MG A S 3 FT #HET 154 153 ASP A 2 461 GLV A S 4 FT #HET 181 180 HIS A 2 461 GLV A S 1 FT #HET 192 191 SER A 3 471 SIN A A 6 FT #HET 193 192 GLY A 3 471 SIN A B 5 FT #HET 194 193 HIS A 3 471 SIN A S 8 FT #HET 229 228 ARG A 2 461 GLV A S 2 FT #HET 229 228 ARG A 3 471 SIN A S 5 FT #HET 284 283 TRP A 2 461 GLV A S 2 FT #HET 286 285 GLU A 3 471 SIN A S 5 FT #HET 314 313 ASN A 3 471 SIN A S 5 FT #HET 316 315 SER A 3 471 SIN A A 5 FT #HET 318 317 SER A 3 471 SIN A S 3 FT #HET 348 347 THR A 2 461 GLV A S 3 FT #HET 348 347 THR A 3 471 SIN A S 7 FT DISORDER 1 1 FT DISORDER 429 429 CC SEQUENCE 427 AA (ATOM); CC ASVVGTPKSA EQIQQEWDTN PRWKDVTRTY SAEDVVALQG SVVEEHTLAR RGAEVLWEQL CC HDLEWVNALG ALTGNMAVQQ VRAGLKAIYL SGWQVAGDAN LSGHTYPDQS LYPANSVPQV CC VRRINNALQR ADQIAKIEGD TSVENWLAPI VADGEAGFGG ALNVYELQKA LIAAGVAGSH CC WEDQLASEKK SGHLGGKVLI PTQQHIRTLT SARLAADVAD VPTVVIARTD AEAATLITSD CC VDERDQPFIT GERTREGFYR TKNGIEPCIA RAKAYAPFAD LIWMETGTPD LEAARQFSEA CC VKAEYPDQML AYNCSPSFNW KKHLDDATIA KFQKELAAMG FKFQFITLAG FHALNYSMFD CC LAYGYAQNQM SAYVELQERE FAAEERGYTA TKHQREVGAG YFDRIATTVD PNSSTTALTG CC STEEGQF CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA CC ATOM -ASVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA CC ************************************************* CC SEQRES RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA CC ATOM RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA CC ************************************************** CC SEQRES NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP CC ATOM NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP CC ************************************************** CC SEQRES IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKSGHLGGKVL CC ATOM IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKSGHLGGKVL CC ************************************************** CC SEQRES IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI CC ATOM IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI CC ************************************************** CC SEQRES TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE CC ATOM TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE CC ************************************************** CC SEQRES AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA CC ATOM AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA CC ************************************************** CC SEQRES GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA CC ATOM GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA CC ************************************************** CC SEQRES GYFDRIATTVDPNSSTTALTGSTEEGQFH CC ATOM GYFDRIATTVDPNSSTTALTGSTEEGQF- CC **************************** SQ SEQUENCE 429 AA; MW; CN; MASVVGTPKS AEQIQQEWDT NPRWKDVTRT YSAEDVVALQ GSVVEEHTLA RRGAEVLWEQ LHDLEWVNAL GALTGNMAVQ QVRAGLKAIY LSGWQVAGDA NLSGHTYPDQ SLYPANSVPQ VVRRINNALQ RADQIAKIEG DTSVENWLAP IVADGEAGFG GALNVYELQK ALIAAGVAGS HWEDQLASEK KSGHLGGKVL IPTQQHIRTL TSARLAADVA DVPTVVIART DAEAATLITS DVDERDQPFI TGERTREGFY RTKNGIEPCI ARAKAYAPFA DLIWMETGTP DLEAARQFSE AVKAEYPDQM LAYNCSPSFN WKKHLDDATI AKFQKELAAM GFKFQFITLA GFHALNYSMF DLAYGYAQNQ MSAYVELQER EFAAEERGYT ATKHQREVGA GYFDRIATTV DPNSSTTALT GSTEEGQFH // ID 1F8IB STANDARD; PRT; 429 AA. DT CONVERTED FROM PDB (SEQRES) 1F8I DE ISOCITRATE LYASE OS Mycobacterium tuberculosis H37Rv CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.250 CC R-Factor 0.166 FT #SUB 66 65 TRP B 370 369 GLN A Protein S 2 FT #SUB 68 67 ASN B 366 365 TYR A Protein S 6 FT #SUB 68 67 ASN B 370 369 GLN A Protein S 1 FT #SUB 69 68 ALA B 366 365 TYR A Protein B 7 FT #SUB 70 69 LEU B 363 362 ALA A Protein S 3 FT #SUB 70 69 LEU B 366 365 TYR A Protein S 9 FT #SUB 74 73 THR B 99 98 ASP A Protein A 8 FT #SUB 74 73 THR B 355 354 LEU A Protein S 2 FT #SUB 75 74 GLY B 99 98 ASP A Protein B 4 FT #SUB 76 75 ASN B 98 97 GLY A Protein S 1 FT #SUB 76 75 ASN B 99 98 ASP A Protein A 17 FT #SUB 76 75 ASN B 352 351 PHE A Protein S 2 FT #SUB 76 75 ASN B 356 355 ASN A Protein A 9 FT #SUB 77 76 MET B 355 354 LEU A Protein S 1 FT #SUB 77 76 MET B 359 358 MET A Protein B 1 FT #SUB 80 79 GLN B 356 355 ASN A Protein S 10 FT #SUB 80 79 GLN B 360 359 PHE A Protein S 5 FT #SUB 81 80 GLN B 359 358 MET A Protein S 4 FT #SUB 81 80 GLN B 363 362 ALA A Protein B 1 FT #SUB 83 82 ARG B 360 359 PHE A Protein S 1 FT #SUB 84 83 ALA B 363 362 ALA A Protein S 2 FT #SUB 84 83 ALA B 364 363 TYR A Protein S 2 FT #SUB 84 83 ALA B 367 366 ALA A Protein B 1 FT #SUB 86 85 LEU B 363 362 ALA A Protein S 1 FT #SUB 86 85 LEU B 366 365 TYR A Protein S 2 FT #SUB 94 93 TRP B 394 393 HIS A Protein S 8 FT #SUB 94 93 TRP B 395 394 GLN A Protein S 4 FT #SUB 94 93 TRP B 398 397 VAL A Protein S 1 FT #SUB 98 97 GLY B 76 75 ASN A Protein B 1 FT #SUB 98 97 GLY B 124 123 ARG A Protein B 1 FT #SUB 98 97 GLY B 398 397 VAL A Protein B 1 FT #SUB 99 98 ASP B 74 73 THR A Protein S 8 FT #SUB 99 98 ASP B 75 74 GLY A Protein S 3 FT #SUB 99 98 ASP B 76 75 ASN A Protein S 17 FT #SUB 99 98 ASP B 124 123 ARG A Protein A 5 FT #SUB 104 103 GLY B 124 123 ARG A Protein B 8 FT #SUB 104 103 GLY B 127 126 ASN A Protein B 5 FT #SUB 105 104 HIS B 124 123 ARG A Protein B 3 FT #SUB 105 104 HIS B 127 126 ASN A Protein S 7 FT #SUB 105 104 HIS B 131 130 ARG A Protein S 1 FT #SUB 106 105 THR B 124 123 ARG A Protein A 6 FT #SUB 106 105 THR B 128 127 ALA A Protein S 2 FT #SUB 106 105 THR B 131 130 ARG A Protein B 5 FT #SUB 106 105 THR B 398 397 VAL A Protein A 4 FT #SUB 107 106 TYR B 131 130 ARG A Protein S 2 FT #SUB 107 106 TYR B 398 397 VAL A Protein B 7 FT #SUB 107 106 TYR B 403 402 PHE A Protein S 2 FT #SUB 108 107 PRO B 398 397 VAL A Protein A 4 FT #SUB 108 107 PRO B 400 399 ALA A Protein S 2 FT #SUB 108 107 PRO B 403 402 PHE A Protein S 4 FT #SUB 110 109 GLN B 418 417 ALA A Protein S 1 FT #SUB 112 111 LEU B 403 402 PHE A Protein S 2 FT #SUB 124 123 ARG B 98 97 GLY A Protein S 1 FT #SUB 124 123 ARG B 99 98 ASP A Protein S 5 FT #SUB 124 123 ARG B 104 103 GLY A Protein A 8 FT #SUB 124 123 ARG B 105 104 HIS A Protein S 3 FT #SUB 124 123 ARG B 106 105 THR A Protein S 6 FT #SUB 127 126 ASN B 104 103 GLY A Protein S 5 FT #SUB 127 126 ASN B 105 104 HIS A Protein S 9 FT #SUB 128 127 ALA B 106 105 THR A Protein A 2 FT #SUB 131 130 ARG B 106 105 THR A Protein S 3 FT #SUB 131 130 ARG B 107 106 TYR A Protein S 2 FT #SUB 189 188 GLU B 416 415 THR A Protein S 4 FT #SUB 191 190 LYS B 416 415 THR A Protein S 5 FT #SUB 191 190 LYS B 417 416 THR A Protein S 2 FT #SUB 192 191 SER B 395 394 GLN A Protein S 1 FT #SUB 194 193 HIS B 422 421 SER A Protein B 3 FT #SUB 194 193 HIS B 423 422 THR A Protein A 6 FT #SUB 195 194 LEU B 395 394 GLN A Protein S 7 FT #SUB 195 194 LEU B 418 417 ALA A Protein A 4 FT #SUB 195 194 LEU B 422 421 SER A Protein A 2 FT #SUB 196 195 GLY B 417 416 THR A Protein B 2 FT #SUB 196 195 GLY B 418 417 ALA A Protein B 6 FT #SUB 196 195 GLY B 420 419 THR A Protein B 2 FT #SUB 197 196 GLY B 416 415 THR A Protein B 2 FT #SUB 197 196 GLY B 417 416 THR A Protein B 2 FT #SUB 199 198 VAL B 416 415 THR A Protein S 1 FT #SUB 237 236 LEU B 415 414 SER A Protein S 1 FT #SUB 255 254 THR B 415 414 SER A Protein S 2 FT #SUB 256 255 ARG B 413 412 ASN A Protein S 1 FT #SUB 257 256 GLU B 414 413 SER A Protein S 2 FT #SUB 257 256 GLU B 415 414 SER A Protein S 6 FT #SUB 259 258 PHE B 416 415 THR A Protein S 1 FT #SUB 288 287 GLY B 423 422 THR A Protein B 1 FT #SUB 288 287 GLY B 427 426 GLN A Protein B 1 FT #SUB 289 288 THR B 427 426 GLN A Protein S 1 FT #SUB 315 314 CYS B 371 370 MET A Protein S 3 FT #SUB 317 316 PRO B 374 373 TYR A Protein S 6 FT #SUB 317 316 PRO B 378 377 GLN A Protein B 1 FT #SUB 317 316 PRO B 394 393 HIS A Protein B 2 FT #SUB 317 316 PRO B 428 427 PHE A Protein B 1 FT #SUB 318 317 SER B 394 393 HIS A Protein A 7 FT #SUB 318 317 SER B 395 394 GLN A Protein S 1 FT #SUB 318 317 SER B 423 422 THR A Protein A 4 FT #SUB 318 317 SER B 427 426 GLN A Protein B 1 FT #SUB 318 317 SER B 428 427 PHE A Protein B 2 FT #SUB 319 318 PHE B 378 377 GLN A Protein B 4 FT #SUB 319 318 PHE B 427 426 GLN A Protein B 2 FT #SUB 319 318 PHE B 428 427 PHE A Protein B 1 FT #SUB 320 319 ASN B 382 381 PHE A Protein S 5 FT #SUB 320 319 ASN B 427 426 GLN A Protein A 4 FT #SUB 321 320 TRP B 371 370 MET A Protein S 3 FT #SUB 321 320 TRP B 375 374 VAL A Protein S 1 FT #SUB 321 320 TRP B 378 377 GLN A Protein A 5 FT #SUB 322 321 LYS B 375 374 VAL A Protein S 2 FT #SUB 322 321 LYS B 379 378 GLU A Protein S 5 FT #SUB 323 322 LYS B 426 425 GLY A Protein S 1 FT #SUB 323 322 LYS B 427 426 GLN A Protein S 4 FT #SUB 324 323 HIS B 427 426 GLN A Protein S 6 FT #SUB 330 329 ILE B 371 370 MET A Protein A 3 FT #SUB 330 329 ILE B 372 371 SER A Protein S 3 FT #SUB 330 329 ILE B 375 374 VAL A Protein S 2 FT #SUB 331 330 ALA B 372 371 SER A Protein A 3 FT #SUB 334 333 GLN B 366 365 TYR A Protein S 5 FT #SUB 334 333 GLN B 370 369 GLN A Protein S 6 FT #SUB 334 333 GLN B 371 370 MET A Protein S 2 FT #SUB 345 344 GLN B 366 365 TYR A Protein B 1 FT #SUB 347 346 ILE B 366 365 TYR A Protein S 3 FT #SUB 347 346 ILE B 371 370 MET A Protein S 2 FT #SUB 347 346 ILE B 374 373 TYR A Protein S 3 FT #SUB 349 348 LEU B 394 393 HIS A Protein S 5 FT #SUB 350 349 ALA B 362 361 LEU A Protein S 1 FT #SUB 350 349 ALA B 374 373 TYR A Protein B 1 FT #SUB 351 350 GLY B 359 358 MET A Protein B 2 FT #SUB 352 351 PHE B 76 75 ASN A Protein S 2 FT #SUB 352 351 PHE B 391 390 ALA A Protein S 1 FT #SUB 352 351 PHE B 394 393 HIS A Protein S 1 FT #SUB 352 351 PHE B 397 396 GLU A Protein S 1 FT #SUB 353 352 HIS B 374 373 TYR A Protein S 4 FT #SUB 353 352 HIS B 381 380 GLU A Protein A 12 FT #SUB 353 352 HIS B 391 390 ALA A Protein S 2 FT #SUB 353 352 HIS B 392 391 THR A Protein S 1 FT #SUB 353 352 HIS B 394 393 HIS A Protein S 4 FT #SUB 354 353 ALA B 358 357 SER A Protein A 4 FT #SUB 355 354 LEU B 74 73 THR A Protein S 3 FT #SUB 355 354 LEU B 76 75 ASN A Protein S 1 FT #SUB 355 354 LEU B 77 76 MET A Protein S 2 FT #SUB 356 355 ASN B 76 75 ASN A Protein S 9 FT #SUB 356 355 ASN B 80 79 GLN A Protein A 10 FT #SUB 356 355 ASN B 389 388 TYR A Protein A 4 FT #SUB 356 355 ASN B 391 390 ALA A Protein S 1 FT #SUB 357 356 TYR B 377 376 LEU A Protein S 1 FT #SUB 357 356 TYR B 380 379 ARG A Protein S 3 FT #SUB 357 356 TYR B 381 380 GLU A Protein S 2 FT #SUB 357 356 TYR B 384 383 ALA A Protein S 1 FT #SUB 357 356 TYR B 387 386 ARG A Protein S 1 FT #SUB 357 356 TYR B 389 388 TYR A Protein A 5 FT #SUB 358 357 SER B 354 353 ALA A Protein S 3 FT #SUB 358 357 SER B 358 357 SER A Protein S 4 FT #SUB 359 358 MET B 77 76 MET A Protein S 2 FT #SUB 359 358 MET B 81 80 GLN A Protein S 5 FT #SUB 359 358 MET B 350 349 ALA A Protein S 1 FT #SUB 359 358 MET B 351 350 GLY A Protein S 1 FT #SUB 359 358 MET B 354 353 ALA A Protein S 1 FT #SUB 360 359 PHE B 80 79 GLN A Protein A 5 FT #SUB 360 359 PHE B 83 82 ARG A Protein S 2 FT #SUB 360 359 PHE B 84 83 ALA A Protein A 2 FT #SUB 360 359 PHE B 387 386 ARG A Protein S 1 FT #SUB 360 359 PHE B 388 387 GLY A Protein S 1 FT #SUB 360 359 PHE B 389 388 TYR A Protein S 10 FT #SUB 361 360 ASP B 387 386 ARG A Protein S 3 FT #SUB 362 361 LEU B 350 349 ALA A Protein S 1 FT #SUB 363 362 ALA B 70 69 LEU A Protein A 3 FT #SUB 363 362 ALA B 81 80 GLN A Protein S 1 FT #SUB 363 362 ALA B 84 83 ALA A Protein A 2 FT #SUB 364 363 TYR B 84 83 ALA A Protein B 2 FT #SUB 364 363 TYR B 387 386 ARG A Protein S 6 FT #SUB 366 365 TYR B 68 67 ASN A Protein S 9 FT #SUB 366 365 TYR B 69 68 ALA A Protein S 7 FT #SUB 366 365 TYR B 70 69 LEU A Protein S 9 FT #SUB 366 365 TYR B 86 85 LEU A Protein S 2 FT #SUB 366 365 TYR B 334 333 GLN A Protein S 5 FT #SUB 366 365 TYR B 345 344 GLN A Protein S 1 FT #SUB 366 365 TYR B 347 346 ILE A Protein S 2 FT #SUB 367 366 ALA B 84 83 ALA A Protein S 1 FT #SUB 370 369 GLN B 66 65 TRP A Protein S 2 FT #SUB 370 369 GLN B 68 67 ASN A Protein S 1 FT #SUB 370 369 GLN B 334 333 GLN A Protein S 6 FT #SUB 371 370 MET B 315 314 CYS A Protein S 3 FT #SUB 371 370 MET B 321 320 TRP A Protein S 3 FT #SUB 371 370 MET B 330 329 ILE A Protein A 4 FT #SUB 371 370 MET B 334 333 GLN A Protein S 2 FT #SUB 371 370 MET B 347 346 ILE A Protein S 2 FT #SUB 372 371 SER B 330 329 ILE A Protein B 2 FT #SUB 372 371 SER B 331 330 ALA A Protein S 3 FT #SUB 374 373 TYR B 317 316 PRO A Protein S 5 FT #SUB 374 373 TYR B 347 346 ILE A Protein S 4 FT #SUB 374 373 TYR B 353 352 HIS A Protein S 3 FT #SUB 375 374 VAL B 321 320 TRP A Protein S 1 FT #SUB 375 374 VAL B 322 321 LYS A Protein S 2 FT #SUB 375 374 VAL B 330 329 ILE A Protein S 1 FT #SUB 377 376 LEU B 354 353 ALA A Protein S 1 FT #SUB 377 376 LEU B 357 356 TYR A Protein S 1 FT #SUB 378 377 GLN B 317 316 PRO A Protein S 1 FT #SUB 378 377 GLN B 319 318 PHE A Protein S 4 FT #SUB 378 377 GLN B 320 319 ASN A Protein S 1 FT #SUB 378 377 GLN B 321 320 TRP A Protein S 5 FT #SUB 379 378 GLU B 322 321 LYS A Protein S 5 FT #SUB 380 379 ARG B 357 356 TYR A Protein A 4 FT #SUB 381 380 GLU B 353 352 HIS A Protein S 13 FT #SUB 381 380 GLU B 357 356 TYR A Protein S 1 FT #SUB 382 381 PHE B 320 319 ASN A Protein S 4 FT #SUB 384 383 ALA B 357 356 TYR A Protein S 1 FT #SUB 387 386 ARG B 357 356 TYR A Protein S 1 FT #SUB 387 386 ARG B 360 359 PHE A Protein A 4 FT #SUB 387 386 ARG B 361 360 ASP A Protein S 3 FT #SUB 387 386 ARG B 364 363 TYR A Protein A 7 FT #SUB 389 388 TYR B 356 355 ASN A Protein S 4 FT #SUB 389 388 TYR B 357 356 TYR A Protein S 7 FT #SUB 389 388 TYR B 360 359 PHE A Protein A 10 FT #SUB 391 390 ALA B 352 351 PHE A Protein B 1 FT #SUB 391 390 ALA B 353 352 HIS A Protein B 2 FT #SUB 391 390 ALA B 356 355 ASN A Protein S 1 FT #SUB 392 391 THR B 353 352 HIS A Protein B 1 FT #SUB 394 393 HIS B 94 93 TRP A Protein A 7 FT #SUB 394 393 HIS B 317 316 PRO A Protein S 2 FT #SUB 394 393 HIS B 318 317 SER A Protein S 6 FT #SUB 394 393 HIS B 349 348 LEU A Protein S 5 FT #SUB 394 393 HIS B 352 351 PHE A Protein S 3 FT #SUB 394 393 HIS B 353 352 HIS A Protein S 5 FT #SUB 395 394 GLN B 94 93 TRP A Protein S 4 FT #SUB 395 394 GLN B 192 191 SER A Protein S 1 FT #SUB 395 394 GLN B 195 194 LEU A Protein S 7 FT #SUB 395 394 GLN B 318 317 SER A Protein S 1 FT #SUB 397 396 GLU B 352 351 PHE A Protein S 1 FT #SUB 398 397 VAL B 94 93 TRP A Protein S 1 FT #SUB 398 397 VAL B 98 97 GLY A Protein S 1 FT #SUB 398 397 VAL B 106 105 THR A Protein A 3 FT #SUB 398 397 VAL B 107 106 TYR A Protein A 8 FT #SUB 398 397 VAL B 108 107 PRO A Protein A 3 FT #SUB 400 399 ALA B 108 107 PRO A Protein B 2 FT #SUB 403 402 PHE B 107 106 TYR A Protein S 2 FT #SUB 403 402 PHE B 108 107 PRO A Protein S 5 FT #SUB 403 402 PHE B 112 111 LEU A Protein S 2 FT #SUB 413 412 ASN B 256 255 ARG A Protein S 1 FT #SUB 414 413 SER B 257 256 GLU A Protein B 2 FT #SUB 415 414 SER B 237 236 LEU A Protein A 2 FT #SUB 415 414 SER B 255 254 THR A Protein S 3 FT #SUB 415 414 SER B 257 256 GLU A Protein A 8 FT #SUB 416 415 THR B 189 188 GLU A Protein S 4 FT #SUB 416 415 THR B 191 190 LYS A Protein A 5 FT #SUB 416 415 THR B 197 196 GLY A Protein A 2 FT #SUB 416 415 THR B 199 198 VAL A Protein S 1 FT #SUB 416 415 THR B 259 258 PHE A Protein S 1 FT #SUB 417 416 THR B 196 195 GLY A Protein B 2 FT #SUB 417 416 THR B 197 196 GLY A Protein B 2 FT #SUB 418 417 ALA B 110 109 GLN A Protein S 1 FT #SUB 418 417 ALA B 195 194 LEU A Protein A 5 FT #SUB 418 417 ALA B 196 195 GLY A Protein B 6 FT #SUB 420 419 THR B 196 195 GLY A Protein B 1 FT #SUB 422 421 SER B 194 193 HIS A Protein A 3 FT #SUB 422 421 SER B 195 194 LEU A Protein S 2 FT #SUB 422 421 SER B 196 195 GLY A Protein A 3 FT #SUB 423 422 THR B 194 193 HIS A Protein A 4 FT #SUB 423 422 THR B 288 287 GLY A Protein S 1 FT #SUB 423 422 THR B 318 317 SER A Protein S 4 FT #SUB 426 425 GLY B 323 322 LYS A Protein B 1 FT #SUB 427 426 GLN B 288 287 GLY A Protein S 1 FT #SUB 427 426 GLN B 319 318 PHE A Protein S 2 FT #SUB 427 426 GLN B 320 319 ASN A Protein A 4 FT #SUB 427 426 GLN B 323 322 LYS A Protein B 3 FT #SUB 427 426 GLN B 324 323 HIS A Protein S 5 FT #SUB 428 427 PHE B 317 316 PRO A Protein S 1 FT #SUB 428 427 PHE B 318 317 SER A Protein S 2 FT #SUB 428 427 PHE B 320 319 ASN A Protein S 1 FT #SUB 2 1 ALA B 59 58 GLU C Protein B 1 FT #SUB 3 2 SER B 52 51 ARG C Protein A 3 FT #SUB 3 2 SER B 56 55 VAL C Protein S 1 FT #SUB 5 4 VAL B 48 47 THR C Protein S 1 FT #SUB 5 4 VAL B 52 51 ARG C Protein A 5 FT #SUB 5 4 VAL B 55 54 GLU C Protein S 1 FT #SUB 31 30 TYR B 409 408 THR C Protein S 2 FT #SUB 35 34 ASP B 409 408 THR C Protein S 1 FT #SUB 37 36 VAL B 137 136 LYS C Protein A 4 FT #SUB 38 37 ALA B 138 137 ILE C Protein B 1 FT #SUB 38 37 ALA B 405 404 ARG C Protein S 2 FT #SUB 39 38 LEU B 402 401 TYR C Protein A 8 FT #SUB 39 38 LEU B 405 404 ARG C Protein S 1 FT #SUB 39 38 LEU B 406 405 ILE C Protein S 1 FT #SUB 41 40 GLY B 133 132 ASP C Protein B 2 FT #SUB 41 40 GLY B 137 136 LYS C Protein B 8 FT #SUB 42 41 SER B 133 132 ASP C Protein A 9 FT #SUB 43 42 VAL B 52 51 ARG C Protein S 3 FT #SUB 43 42 VAL B 133 132 ASP C Protein B 1 FT #SUB 43 42 VAL B 148 147 LEU C Protein S 3 FT #SUB 44 43 VAL B 48 47 THR C Protein B 1 FT #SUB 45 44 GLU B 48 47 THR C Protein B 3 FT #SUB 45 44 GLU B 49 48 LEU C Protein S 5 FT #SUB 45 44 GLU B 123 122 ARG C Protein S 7 FT #SUB 45 44 GLU B 130 129 GLN C Protein S 5 FT #SUB 46 45 GLU B 46 45 GLU C Protein A 5 FT #SUB 46 45 GLU B 48 47 THR C Protein A 4 FT #SUB 48 47 THR B 5 4 VAL C Protein B 1 FT #SUB 48 47 THR B 44 43 VAL C Protein S 1 FT #SUB 48 47 THR B 45 44 GLU C Protein S 3 FT #SUB 48 47 THR B 46 45 GLU C Protein S 4 FT #SUB 49 48 LEU B 45 44 GLU C Protein S 5 FT #SUB 51 50 ARG B 5 4 VAL C Protein S 1 FT #SUB 52 51 ARG B 3 2 SER C Protein S 5 FT #SUB 52 51 ARG B 5 4 VAL C Protein S 3 FT #SUB 52 51 ARG B 43 42 VAL C Protein S 2 FT #SUB 55 54 GLU B 3 2 SER C Protein S 1 FT #SUB 55 54 GLU B 5 4 VAL C Protein S 1 FT #SUB 56 55 VAL B 3 2 SER C Protein S 1 FT #SUB 59 58 GLU B 2 1 ALA C Protein S 2 FT #SUB 123 122 ARG B 45 44 GLU C Protein S 7 FT #SUB 130 129 GLN B 45 44 GLU C Protein S 5 FT #SUB 131 130 ARG B 170 169 LYS C Protein S 1 FT #SUB 133 132 ASP B 41 40 GLY C Protein S 2 FT #SUB 133 132 ASP B 42 41 SER C Protein S 9 FT #SUB 133 132 ASP B 43 42 VAL C Protein S 1 FT #SUB 137 136 LYS B 37 36 VAL C Protein S 4 FT #SUB 137 136 LYS B 38 37 ALA C Protein S 1 FT #SUB 137 136 LYS B 41 40 GLY C Protein S 8 FT #SUB 138 137 ILE B 38 37 ALA C Protein S 1 FT #SUB 148 147 LEU B 43 42 VAL C Protein S 3 FT #SUB 163 162 LEU B 403 402 PHE C Protein S 1 FT #SUB 163 162 LEU B 406 405 ILE C Protein S 1 FT #SUB 166 165 TYR B 406 405 ILE C Protein S 3 FT #SUB 167 166 GLU B 403 402 PHE C Protein S 2 FT #SUB 208 207 ARG B 410 409 VAL C Protein B 1 FT #SUB 208 207 ARG B 411 410 ASP C Protein S 2 FT #SUB 212 211 SER B 410 409 VAL C Protein A 3 FT #SUB 215 214 LEU B 409 408 THR C Protein S 3 FT #SUB 215 214 LEU B 410 409 VAL C Protein S 1 FT #SUB 402 401 TYR B 39 38 LEU C Protein S 8 FT #SUB 403 402 PHE B 163 162 LEU C Protein B 1 FT #SUB 403 402 PHE B 167 166 GLU C Protein S 2 FT #SUB 405 404 ARG B 38 37 ALA C Protein S 2 FT #SUB 405 404 ARG B 39 38 LEU C Protein S 2 FT #SUB 406 405 ILE B 39 38 LEU C Protein S 2 FT #SUB 406 405 ILE B 163 162 LEU C Protein S 1 FT #SUB 406 405 ILE B 166 165 TYR C Protein S 2 FT #SUB 409 408 THR B 31 30 TYR C Protein A 3 FT #SUB 409 408 THR B 35 34 ASP C Protein S 1 FT #SUB 409 408 THR B 215 214 LEU C Protein S 3 FT #SUB 410 409 VAL B 208 207 ARG C Protein S 1 FT #SUB 410 409 VAL B 212 211 SER C Protein S 2 FT #SUB 410 409 VAL B 215 214 LEU C Protein S 1 FT #SUB 411 410 ASP B 208 207 ARG C Protein S 3 FT #SUB 102 101 LEU B 116 115 ASN D Protein B 1 FT #SUB 107 106 TYR B 167 166 GLU D Protein S 11 FT #SUB 110 109 GLN B 163 162 LEU D Protein S 1 FT #SUB 111 110 SER B 164 163 ASN D Protein B 1 FT #SUB 112 111 LEU B 163 162 LEU D Protein S 1 FT #SUB 112 111 LEU B 164 163 ASN D Protein B 1 FT #SUB 114 113 PRO B 116 115 ASN D Protein S 4 FT #SUB 116 115 ASN B 102 101 LEU D Protein S 1 FT #SUB 116 115 ASN B 114 113 PRO D Protein S 5 FT #SUB 160 159 GLY B 188 187 SER D Protein B 3 FT #SUB 161 160 GLY B 188 187 SER D Protein B 4 FT #SUB 163 162 LEU B 110 109 GLN D Protein S 1 FT #SUB 163 162 LEU B 112 111 LEU D Protein A 2 FT #SUB 164 163 ASN B 111 110 SER D Protein S 1 FT #SUB 164 163 ASN B 112 111 LEU D Protein S 2 FT #SUB 164 163 ASN B 188 187 SER D Protein S 1 FT #SUB 167 166 GLU B 107 106 TYR D Protein S 11 FT #SUB 188 187 SER B 160 159 GLY D Protein A 4 FT #SUB 188 187 SER B 161 160 GLY D Protein A 5 FT #SUB 188 187 SER B 164 163 ASN D Protein B 1 FT #SUB 189 188 GLU B 161 160 GLY D Protein S 1 FT #SUB 208 207 ARG B 257 256 GLU D Protein S 1 FT #SUB 241 240 ASP B 254 253 ARG D Protein S 1 FT #SUB 242 241 VAL B 256 255 ARG D Protein S 1 FT #SUB 242 241 VAL B 257 256 GLU D Protein S 1 FT #SUB 242 241 VAL B 258 257 GLY D Protein S 1 FT #SUB 254 253 ARG B 241 240 ASP D Protein S 1 FT #SUB 255 254 THR B 242 241 VAL D Protein B 1 FT #SUB 256 255 ARG B 242 241 VAL D Protein B 2 FT #SUB 257 256 GLU B 208 207 ARG D Protein S 1 FT #SUB 258 257 GLY B 242 241 VAL D Protein B 3 FT #SUB 260 259 TYR B 260 259 TYR D Protein S 1 FT #HET 90 89 TYR B 5 462 GLV B S 5 FT #HET 92 91 SER B 5 462 GLV B A 5 FT #HET 93 92 GLY B 5 462 GLV B B 5 FT #HET 94 93 TRP B 4 452 MG B B 1 FT #HET 94 93 TRP B 5 462 GLV B A 7 FT #HET 94 93 TRP B 6 472 SIN B S 1 FT #HET 109 108 ASP B 4 452 MG B S 2 FT #HET 109 108 ASP B 5 462 GLV B S 1 FT #HET 109 108 ASP B 6 472 SIN B S 2 FT #HET 154 153 ASP B 4 452 MG B S 3 FT #HET 154 153 ASP B 5 462 GLV B S 4 FT #HET 181 180 HIS B 5 462 GLV B S 1 FT #HET 192 191 SER B 6 472 SIN B A 5 FT #HET 193 192 GLY B 6 472 SIN B B 5 FT #HET 194 193 HIS B 6 472 SIN B S 9 FT #HET 229 228 ARG B 5 462 GLV B S 2 FT #HET 229 228 ARG B 6 472 SIN B S 5 FT #HET 284 283 TRP B 5 462 GLV B S 2 FT #HET 286 285 GLU B 6 472 SIN B S 4 FT #HET 314 313 ASN B 6 472 SIN B S 5 FT #HET 316 315 SER B 6 472 SIN B A 5 FT #HET 318 317 SER B 6 472 SIN B S 3 FT #HET 348 347 THR B 5 462 GLV B S 3 FT #HET 348 347 THR B 6 472 SIN B S 6 FT #HET 349 348 LEU B 6 472 SIN B S 1 FT DISORDER 1 1 FT DISORDER 429 429 CC SEQUENCE 427 AA (ATOM); CC ASVVGTPKSA EQIQQEWDTN PRWKDVTRTY SAEDVVALQG SVVEEHTLAR RGAEVLWEQL CC HDLEWVNALG ALTGNMAVQQ VRAGLKAIYL SGWQVAGDAN LSGHTYPDQS LYPANSVPQV CC VRRINNALQR ADQIAKIEGD TSVENWLAPI VADGEAGFGG ALNVYELQKA LIAAGVAGSH CC WEDQLASEKK SGHLGGKVLI PTQQHIRTLT SARLAADVAD VPTVVIARTD AEAATLITSD CC VDERDQPFIT GERTREGFYR TKNGIEPCIA RAKAYAPFAD LIWMETGTPD LEAARQFSEA CC VKAEYPDQML AYNCSPSFNW KKHLDDATIA KFQKELAAMG FKFQFITLAG FHALNYSMFD CC LAYGYAQNQM SAYVELQERE FAAEERGYTA TKHQREVGAG YFDRIATTVD PNSSTTALTG CC STEEGQF CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA CC ATOM -ASVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA CC ************************************************* CC SEQRES RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA CC ATOM RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA CC ************************************************** CC SEQRES NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP CC ATOM NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP CC ************************************************** CC SEQRES IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKSGHLGGKVL CC ATOM IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKSGHLGGKVL CC ************************************************** CC SEQRES IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI CC ATOM IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI CC ************************************************** CC SEQRES TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE CC ATOM TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE CC ************************************************** CC SEQRES AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA CC ATOM AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA CC ************************************************** CC SEQRES GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA CC ATOM GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA CC ************************************************** CC SEQRES GYFDRIATTVDPNSSTTALTGSTEEGQFH CC ATOM GYFDRIATTVDPNSSTTALTGSTEEGQF- CC **************************** SQ SEQUENCE 429 AA; MW; CN; MASVVGTPKS AEQIQQEWDT NPRWKDVTRT YSAEDVVALQ GSVVEEHTLA RRGAEVLWEQ LHDLEWVNAL GALTGNMAVQ QVRAGLKAIY LSGWQVAGDA NLSGHTYPDQ SLYPANSVPQ VVRRINNALQ RADQIAKIEG DTSVENWLAP IVADGEAGFG GALNVYELQK ALIAAGVAGS HWEDQLASEK KSGHLGGKVL IPTQQHIRTL TSARLAADVA DVPTVVIART DAEAATLITS DVDERDQPFI TGERTREGFY RTKNGIEPCI ARAKAYAPFA DLIWMETGTP DLEAARQFSE AVKAEYPDQM LAYNCSPSFN WKKHLDDATI AKFQKELAAM GFKFQFITLA GFHALNYSMF DLAYGYAQNQ MSAYVELQER EFAAEERGYT ATKHQREVGA GYFDRIATTV DPNSSTTALT GSTEEGQFH // ID 1F8IC STANDARD; PRT; 429 AA. DT CONVERTED FROM PDB (SEQRES) 1F8I DE ISOCITRATE LYASE OS Mycobacterium tuberculosis H37Rv CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.250 CC R-Factor 0.166 FT #SUB 102 101 LEU C 116 115 ASN A Protein B 1 FT #SUB 107 106 TYR C 167 166 GLU A Protein S 11 FT #SUB 110 109 GLN C 163 162 LEU A Protein S 1 FT #SUB 111 110 SER C 164 163 ASN A Protein B 2 FT #SUB 112 111 LEU C 163 162 LEU A Protein S 2 FT #SUB 112 111 LEU C 164 163 ASN A Protein A 2 FT #SUB 114 113 PRO C 116 115 ASN A Protein S 4 FT #SUB 116 115 ASN C 102 101 LEU A Protein S 1 FT #SUB 116 115 ASN C 114 113 PRO A Protein S 5 FT #SUB 160 159 GLY C 188 187 SER A Protein B 4 FT #SUB 161 160 GLY C 188 187 SER A Protein B 4 FT #SUB 163 162 LEU C 110 109 GLN A Protein S 1 FT #SUB 163 162 LEU C 112 111 LEU A Protein S 1 FT #SUB 164 163 ASN C 111 110 SER A Protein S 1 FT #SUB 164 163 ASN C 112 111 LEU A Protein S 1 FT #SUB 164 163 ASN C 188 187 SER A Protein S 1 FT #SUB 167 166 GLU C 107 106 TYR A Protein S 11 FT #SUB 188 187 SER C 160 159 GLY A Protein A 5 FT #SUB 188 187 SER C 161 160 GLY A Protein A 5 FT #SUB 188 187 SER C 164 163 ASN A Protein B 1 FT #SUB 208 207 ARG C 257 256 GLU A Protein S 1 FT #SUB 240 239 SER C 254 253 ARG A Protein S 1 FT #SUB 241 240 ASP C 254 253 ARG A Protein S 1 FT #SUB 242 241 VAL C 256 255 ARG A Protein S 1 FT #SUB 242 241 VAL C 257 256 GLU A Protein S 1 FT #SUB 242 241 VAL C 258 257 GLY A Protein S 2 FT #SUB 254 253 ARG C 240 239 SER A Protein S 1 FT #SUB 254 253 ARG C 241 240 ASP A Protein S 1 FT #SUB 256 255 ARG C 242 241 VAL A Protein B 1 FT #SUB 257 256 GLU C 208 207 ARG A Protein S 1 FT #SUB 257 256 GLU C 242 241 VAL A Protein B 1 FT #SUB 258 257 GLY C 242 241 VAL A Protein B 1 FT #SUB 260 259 TYR C 260 259 TYR A Protein S 1 FT #SUB 2 1 ALA C 59 58 GLU B Protein B 2 FT #SUB 3 2 SER C 52 51 ARG B Protein A 5 FT #SUB 3 2 SER C 55 54 GLU B Protein S 1 FT #SUB 3 2 SER C 56 55 VAL B Protein S 1 FT #SUB 5 4 VAL C 48 47 THR B Protein S 1 FT #SUB 5 4 VAL C 51 50 ARG B Protein S 1 FT #SUB 5 4 VAL C 52 51 ARG B Protein A 3 FT #SUB 5 4 VAL C 55 54 GLU B Protein S 1 FT #SUB 31 30 TYR C 409 408 THR B Protein S 3 FT #SUB 35 34 ASP C 409 408 THR B Protein S 1 FT #SUB 37 36 VAL C 137 136 LYS B Protein A 4 FT #SUB 38 37 ALA C 137 136 LYS B Protein B 1 FT #SUB 38 37 ALA C 138 137 ILE B Protein B 1 FT #SUB 38 37 ALA C 405 404 ARG B Protein S 2 FT #SUB 39 38 LEU C 402 401 TYR B Protein A 8 FT #SUB 39 38 LEU C 405 404 ARG B Protein S 2 FT #SUB 39 38 LEU C 406 405 ILE B Protein S 2 FT #SUB 41 40 GLY C 133 132 ASP B Protein B 2 FT #SUB 41 40 GLY C 137 136 LYS B Protein B 8 FT #SUB 42 41 SER C 133 132 ASP B Protein A 9 FT #SUB 43 42 VAL C 52 51 ARG B Protein S 2 FT #SUB 43 42 VAL C 133 132 ASP B Protein B 1 FT #SUB 43 42 VAL C 148 147 LEU B Protein S 3 FT #SUB 44 43 VAL C 48 47 THR B Protein B 1 FT #SUB 45 44 GLU C 48 47 THR B Protein B 3 FT #SUB 45 44 GLU C 49 48 LEU B Protein S 5 FT #SUB 45 44 GLU C 123 122 ARG B Protein S 7 FT #SUB 45 44 GLU C 130 129 GLN B Protein S 5 FT #SUB 46 45 GLU C 46 45 GLU B Protein A 5 FT #SUB 46 45 GLU C 48 47 THR B Protein A 4 FT #SUB 48 47 THR C 5 4 VAL B Protein B 1 FT #SUB 48 47 THR C 44 43 VAL B Protein S 1 FT #SUB 48 47 THR C 45 44 GLU B Protein S 3 FT #SUB 48 47 THR C 46 45 GLU B Protein S 4 FT #SUB 49 48 LEU C 45 44 GLU B Protein S 5 FT #SUB 52 51 ARG C 3 2 SER B Protein S 3 FT #SUB 52 51 ARG C 5 4 VAL B Protein S 5 FT #SUB 52 51 ARG C 43 42 VAL B Protein S 3 FT #SUB 55 54 GLU C 5 4 VAL B Protein S 1 FT #SUB 56 55 VAL C 3 2 SER B Protein S 1 FT #SUB 59 58 GLU C 2 1 ALA B Protein S 1 FT #SUB 123 122 ARG C 45 44 GLU B Protein S 7 FT #SUB 130 129 GLN C 45 44 GLU B Protein S 5 FT #SUB 133 132 ASP C 41 40 GLY B Protein S 2 FT #SUB 133 132 ASP C 42 41 SER B Protein S 9 FT #SUB 133 132 ASP C 43 42 VAL B Protein S 1 FT #SUB 137 136 LYS C 37 36 VAL B Protein S 4 FT #SUB 137 136 LYS C 41 40 GLY B Protein S 8 FT #SUB 138 137 ILE C 38 37 ALA B Protein S 1 FT #SUB 148 147 LEU C 43 42 VAL B Protein S 3 FT #SUB 163 162 LEU C 403 402 PHE B Protein S 1 FT #SUB 163 162 LEU C 406 405 ILE B Protein S 1 FT #SUB 166 165 TYR C 406 405 ILE B Protein S 2 FT #SUB 167 166 GLU C 403 402 PHE B Protein S 2 FT #SUB 170 169 LYS C 131 130 ARG B Protein S 1 FT #SUB 208 207 ARG C 410 409 VAL B Protein B 1 FT #SUB 208 207 ARG C 411 410 ASP B Protein S 3 FT #SUB 212 211 SER C 410 409 VAL B Protein A 2 FT #SUB 215 214 LEU C 409 408 THR B Protein S 3 FT #SUB 215 214 LEU C 410 409 VAL B Protein S 1 FT #SUB 402 401 TYR C 39 38 LEU B Protein S 8 FT #SUB 403 402 PHE C 163 162 LEU B Protein B 1 FT #SUB 403 402 PHE C 167 166 GLU B Protein S 2 FT #SUB 405 404 ARG C 38 37 ALA B Protein S 2 FT #SUB 405 404 ARG C 39 38 LEU B Protein S 1 FT #SUB 406 405 ILE C 39 38 LEU B Protein S 1 FT #SUB 406 405 ILE C 163 162 LEU B Protein S 1 FT #SUB 406 405 ILE C 166 165 TYR B Protein S 3 FT #SUB 409 408 THR C 31 30 TYR B Protein A 2 FT #SUB 409 408 THR C 35 34 ASP B Protein S 1 FT #SUB 409 408 THR C 215 214 LEU B Protein S 3 FT #SUB 410 409 VAL C 208 207 ARG B Protein S 1 FT #SUB 410 409 VAL C 212 211 SER B Protein S 3 FT #SUB 410 409 VAL C 215 214 LEU B Protein S 1 FT #SUB 411 410 ASP C 208 207 ARG B Protein S 2 FT #SUB 66 65 TRP C 370 369 GLN D Protein S 3 FT #SUB 68 67 ASN C 366 365 TYR D Protein S 4 FT #SUB 68 67 ASN C 370 369 GLN D Protein S 1 FT #SUB 69 68 ALA C 366 365 TYR D Protein B 7 FT #SUB 70 69 LEU C 362 361 LEU D Protein S 1 FT #SUB 70 69 LEU C 363 362 ALA D Protein S 1 FT #SUB 70 69 LEU C 366 365 TYR D Protein S 9 FT #SUB 74 73 THR C 99 98 ASP D Protein A 8 FT #SUB 74 73 THR C 355 354 LEU D Protein S 2 FT #SUB 75 74 GLY C 99 98 ASP D Protein B 4 FT #SUB 76 75 ASN C 98 97 GLY D Protein S 1 FT #SUB 76 75 ASN C 99 98 ASP D Protein A 18 FT #SUB 76 75 ASN C 352 351 PHE D Protein S 2 FT #SUB 76 75 ASN C 355 354 LEU D Protein S 1 FT #SUB 76 75 ASN C 356 355 ASN D Protein S 8 FT #SUB 77 76 MET C 355 354 LEU D Protein S 1 FT #SUB 77 76 MET C 359 358 MET D Protein A 2 FT #SUB 80 79 GLN C 356 355 ASN D Protein S 10 FT #SUB 80 79 GLN C 360 359 PHE D Protein S 5 FT #SUB 81 80 GLN C 359 358 MET D Protein S 4 FT #SUB 81 80 GLN C 363 362 ALA D Protein B 1 FT #SUB 83 82 ARG C 360 359 PHE D Protein S 1 FT #SUB 84 83 ALA C 360 359 PHE D Protein S 1 FT #SUB 84 83 ALA C 363 362 ALA D Protein S 2 FT #SUB 84 83 ALA C 364 363 TYR D Protein S 2 FT #SUB 84 83 ALA C 367 366 ALA D Protein B 1 FT #SUB 86 85 LEU C 363 362 ALA D Protein S 1 FT #SUB 86 85 LEU C 366 365 TYR D Protein S 1 FT #SUB 86 85 LEU C 367 366 ALA D Protein S 1 FT #SUB 94 93 TRP C 394 393 HIS D Protein S 8 FT #SUB 94 93 TRP C 395 394 GLN D Protein S 4 FT #SUB 94 93 TRP C 398 397 VAL D Protein S 1 FT #SUB 98 97 GLY C 76 75 ASN D Protein B 1 FT #SUB 98 97 GLY C 124 123 ARG D Protein B 1 FT #SUB 98 97 GLY C 398 397 VAL D Protein B 1 FT #SUB 99 98 ASP C 74 73 THR D Protein S 8 FT #SUB 99 98 ASP C 75 74 GLY D Protein S 3 FT #SUB 99 98 ASP C 76 75 ASN D Protein S 17 FT #SUB 99 98 ASP C 124 123 ARG D Protein A 5 FT #SUB 104 103 GLY C 124 123 ARG D Protein B 8 FT #SUB 104 103 GLY C 127 126 ASN D Protein B 4 FT #SUB 105 104 HIS C 124 123 ARG D Protein B 3 FT #SUB 105 104 HIS C 127 126 ASN D Protein S 7 FT #SUB 105 104 HIS C 131 130 ARG D Protein S 1 FT #SUB 106 105 THR C 124 123 ARG D Protein A 6 FT #SUB 106 105 THR C 128 127 ALA D Protein S 2 FT #SUB 106 105 THR C 131 130 ARG D Protein B 5 FT #SUB 106 105 THR C 398 397 VAL D Protein S 3 FT #SUB 107 106 TYR C 131 130 ARG D Protein S 2 FT #SUB 107 106 TYR C 398 397 VAL D Protein B 9 FT #SUB 107 106 TYR C 403 402 PHE D Protein S 2 FT #SUB 108 107 PRO C 398 397 VAL D Protein A 4 FT #SUB 108 107 PRO C 400 399 ALA D Protein S 3 FT #SUB 108 107 PRO C 403 402 PHE D Protein S 4 FT #SUB 112 111 LEU C 403 402 PHE D Protein S 2 FT #SUB 124 123 ARG C 98 97 GLY D Protein S 1 FT #SUB 124 123 ARG C 99 98 ASP D Protein S 5 FT #SUB 124 123 ARG C 104 103 GLY D Protein A 8 FT #SUB 124 123 ARG C 105 104 HIS D Protein S 3 FT #SUB 124 123 ARG C 106 105 THR D Protein S 6 FT #SUB 127 126 ASN C 104 103 GLY D Protein S 5 FT #SUB 127 126 ASN C 105 104 HIS D Protein S 7 FT #SUB 128 127 ALA C 106 105 THR D Protein A 2 FT #SUB 131 130 ARG C 106 105 THR D Protein S 6 FT #SUB 131 130 ARG C 107 106 TYR D Protein S 2 FT #SUB 189 188 GLU C 416 415 THR D Protein S 4 FT #SUB 191 190 LYS C 416 415 THR D Protein S 5 FT #SUB 191 190 LYS C 417 416 THR D Protein S 1 FT #SUB 192 191 SER C 395 394 GLN D Protein S 1 FT #SUB 194 193 HIS C 422 421 SER D Protein B 3 FT #SUB 194 193 HIS C 423 422 THR D Protein A 6 FT #SUB 195 194 LEU C 395 394 GLN D Protein S 6 FT #SUB 195 194 LEU C 418 417 ALA D Protein A 5 FT #SUB 195 194 LEU C 422 421 SER D Protein A 3 FT #SUB 196 195 GLY C 417 416 THR D Protein B 3 FT #SUB 196 195 GLY C 418 417 ALA D Protein B 5 FT #SUB 196 195 GLY C 420 419 THR D Protein B 2 FT #SUB 196 195 GLY C 422 421 SER D Protein B 2 FT #SUB 197 196 GLY C 416 415 THR D Protein B 3 FT #SUB 197 196 GLY C 417 416 THR D Protein B 2 FT #SUB 199 198 VAL C 416 415 THR D Protein S 1 FT #SUB 237 236 LEU C 415 414 SER D Protein S 1 FT #SUB 255 254 THR C 415 414 SER D Protein S 3 FT #SUB 256 255 ARG C 413 412 ASN D Protein S 1 FT #SUB 257 256 GLU C 414 413 SER D Protein S 2 FT #SUB 257 256 GLU C 415 414 SER D Protein S 8 FT #SUB 259 258 PHE C 416 415 THR D Protein S 1 FT #SUB 288 287 GLY C 423 422 THR D Protein B 1 FT #SUB 288 287 GLY C 427 426 GLN D Protein B 1 FT #SUB 315 314 CYS C 371 370 MET D Protein S 3 FT #SUB 317 316 PRO C 374 373 TYR D Protein S 6 FT #SUB 317 316 PRO C 378 377 GLN D Protein B 1 FT #SUB 317 316 PRO C 394 393 HIS D Protein B 2 FT #SUB 317 316 PRO C 428 427 PHE D Protein B 1 FT #SUB 318 317 SER C 394 393 HIS D Protein A 6 FT #SUB 318 317 SER C 423 422 THR D Protein A 4 FT #SUB 318 317 SER C 427 426 GLN D Protein B 1 FT #SUB 318 317 SER C 428 427 PHE D Protein B 1 FT #SUB 319 318 PHE C 378 377 GLN D Protein B 3 FT #SUB 319 318 PHE C 427 426 GLN D Protein A 3 FT #SUB 320 319 ASN C 382 381 PHE D Protein S 5 FT #SUB 320 319 ASN C 427 426 GLN D Protein A 4 FT #SUB 321 320 TRP C 371 370 MET D Protein S 3 FT #SUB 321 320 TRP C 378 377 GLN D Protein A 4 FT #SUB 322 321 LYS C 375 374 VAL D Protein S 2 FT #SUB 322 321 LYS C 379 378 GLU D Protein S 6 FT #SUB 323 322 LYS C 426 425 GLY D Protein S 1 FT #SUB 323 322 LYS C 427 426 GLN D Protein S 2 FT #SUB 324 323 HIS C 427 426 GLN D Protein S 6 FT #SUB 330 329 ILE C 371 370 MET D Protein A 3 FT #SUB 330 329 ILE C 372 371 SER D Protein S 1 FT #SUB 330 329 ILE C 375 374 VAL D Protein S 1 FT #SUB 331 330 ALA C 370 369 GLN D Protein B 1 FT #SUB 331 330 ALA C 372 371 SER D Protein A 3 FT #SUB 334 333 GLN C 366 365 TYR D Protein S 5 FT #SUB 334 333 GLN C 370 369 GLN D Protein S 5 FT #SUB 334 333 GLN C 371 370 MET D Protein S 2 FT #SUB 345 344 GLN C 366 365 TYR D Protein B 1 FT #SUB 347 346 ILE C 366 365 TYR D Protein S 4 FT #SUB 347 346 ILE C 371 370 MET D Protein S 2 FT #SUB 347 346 ILE C 374 373 TYR D Protein S 4 FT #SUB 349 348 LEU C 394 393 HIS D Protein S 5 FT #SUB 350 349 ALA C 362 361 LEU D Protein S 1 FT #SUB 351 350 GLY C 359 358 MET D Protein B 2 FT #SUB 352 351 PHE C 76 75 ASN D Protein S 2 FT #SUB 352 351 PHE C 391 390 ALA D Protein S 1 FT #SUB 352 351 PHE C 394 393 HIS D Protein S 4 FT #SUB 352 351 PHE C 397 396 GLU D Protein S 1 FT #SUB 353 352 HIS C 374 373 TYR D Protein S 4 FT #SUB 353 352 HIS C 381 380 GLU D Protein A 11 FT #SUB 353 352 HIS C 391 390 ALA D Protein S 2 FT #SUB 353 352 HIS C 392 391 THR D Protein S 1 FT #SUB 353 352 HIS C 394 393 HIS D Protein S 4 FT #SUB 354 353 ALA C 358 357 SER D Protein B 2 FT #SUB 354 353 ALA C 359 358 MET D Protein S 1 FT #SUB 354 353 ALA C 377 376 LEU D Protein B 1 FT #SUB 355 354 LEU C 74 73 THR D Protein S 2 FT #SUB 355 354 LEU C 76 75 ASN D Protein S 1 FT #SUB 356 355 ASN C 76 75 ASN D Protein S 9 FT #SUB 356 355 ASN C 80 79 GLN D Protein A 10 FT #SUB 356 355 ASN C 389 388 TYR D Protein A 4 FT #SUB 356 355 ASN C 391 390 ALA D Protein S 1 FT #SUB 357 356 TYR C 377 376 LEU D Protein S 1 FT #SUB 357 356 TYR C 380 379 ARG D Protein S 3 FT #SUB 357 356 TYR C 381 380 GLU D Protein S 3 FT #SUB 357 356 TYR C 384 383 ALA D Protein S 1 FT #SUB 357 356 TYR C 387 386 ARG D Protein S 1 FT #SUB 357 356 TYR C 389 388 TYR D Protein A 6 FT #SUB 358 357 SER C 354 353 ALA D Protein S 2 FT #SUB 358 357 SER C 358 357 SER D Protein S 4 FT #SUB 359 358 MET C 77 76 MET D Protein S 1 FT #SUB 359 358 MET C 81 80 GLN D Protein S 4 FT #SUB 359 358 MET C 351 350 GLY D Protein S 2 FT #SUB 359 358 MET C 354 353 ALA D Protein S 1 FT #SUB 360 359 PHE C 80 79 GLN D Protein A 4 FT #SUB 360 359 PHE C 83 82 ARG D Protein S 1 FT #SUB 360 359 PHE C 387 386 ARG D Protein S 2 FT #SUB 360 359 PHE C 389 388 TYR D Protein S 11 FT #SUB 361 360 ASP C 387 386 ARG D Protein S 3 FT #SUB 363 362 ALA C 70 69 LEU D Protein B 1 FT #SUB 363 362 ALA C 81 80 GLN D Protein S 1 FT #SUB 363 362 ALA C 84 83 ALA D Protein A 2 FT #SUB 364 363 TYR C 84 83 ALA D Protein B 2 FT #SUB 364 363 TYR C 387 386 ARG D Protein S 5 FT #SUB 366 365 TYR C 68 67 ASN D Protein S 5 FT #SUB 366 365 TYR C 69 68 ALA D Protein S 7 FT #SUB 366 365 TYR C 70 69 LEU D Protein S 9 FT #SUB 366 365 TYR C 86 85 LEU D Protein S 2 FT #SUB 366 365 TYR C 334 333 GLN D Protein S 5 FT #SUB 366 365 TYR C 345 344 GLN D Protein S 1 FT #SUB 366 365 TYR C 347 346 ILE D Protein S 3 FT #SUB 367 366 ALA C 84 83 ALA D Protein S 1 FT #SUB 367 366 ALA C 86 85 LEU D Protein S 1 FT #SUB 370 369 GLN C 66 65 TRP D Protein S 4 FT #SUB 370 369 GLN C 68 67 ASN D Protein S 1 FT #SUB 370 369 GLN C 334 333 GLN D Protein S 6 FT #SUB 371 370 MET C 315 314 CYS D Protein S 3 FT #SUB 371 370 MET C 321 320 TRP D Protein S 4 FT #SUB 371 370 MET C 330 329 ILE D Protein A 3 FT #SUB 371 370 MET C 334 333 GLN D Protein S 2 FT #SUB 371 370 MET C 347 346 ILE D Protein S 3 FT #SUB 372 371 SER C 330 329 ILE D Protein B 1 FT #SUB 372 371 SER C 331 330 ALA D Protein S 3 FT #SUB 374 373 TYR C 317 316 PRO D Protein S 6 FT #SUB 374 373 TYR C 347 346 ILE D Protein S 5 FT #SUB 374 373 TYR C 353 352 HIS D Protein S 3 FT #SUB 375 374 VAL C 322 321 LYS D Protein S 2 FT #SUB 375 374 VAL C 330 329 ILE D Protein S 1 FT #SUB 377 376 LEU C 357 356 TYR D Protein S 1 FT #SUB 378 377 GLN C 317 316 PRO D Protein S 1 FT #SUB 378 377 GLN C 319 318 PHE D Protein S 4 FT #SUB 378 377 GLN C 320 319 ASN D Protein S 1 FT #SUB 378 377 GLN C 321 320 TRP D Protein S 3 FT #SUB 379 378 GLU C 322 321 LYS D Protein S 6 FT #SUB 380 379 ARG C 357 356 TYR D Protein A 2 FT #SUB 381 380 GLU C 353 352 HIS D Protein S 12 FT #SUB 381 380 GLU C 357 356 TYR D Protein S 2 FT #SUB 382 381 PHE C 320 319 ASN D Protein S 4 FT #SUB 384 383 ALA C 357 356 TYR D Protein S 1 FT #SUB 387 386 ARG C 357 356 TYR D Protein S 1 FT #SUB 387 386 ARG C 360 359 PHE D Protein B 1 FT #SUB 387 386 ARG C 361 360 ASP D Protein S 3 FT #SUB 387 386 ARG C 364 363 TYR D Protein A 5 FT #SUB 389 388 TYR C 356 355 ASN D Protein S 4 FT #SUB 389 388 TYR C 357 356 TYR D Protein S 7 FT #SUB 389 388 TYR C 360 359 PHE D Protein A 10 FT #SUB 391 390 ALA C 352 351 PHE D Protein B 1 FT #SUB 391 390 ALA C 353 352 HIS D Protein B 2 FT #SUB 391 390 ALA C 356 355 ASN D Protein S 1 FT #SUB 392 391 THR C 353 352 HIS D Protein B 1 FT #SUB 394 393 HIS C 94 93 TRP D Protein A 7 FT #SUB 394 393 HIS C 317 316 PRO D Protein S 2 FT #SUB 394 393 HIS C 318 317 SER D Protein S 6 FT #SUB 394 393 HIS C 349 348 LEU D Protein S 5 FT #SUB 394 393 HIS C 352 351 PHE D Protein A 4 FT #SUB 394 393 HIS C 353 352 HIS D Protein S 4 FT #SUB 395 394 GLN C 94 93 TRP D Protein S 4 FT #SUB 395 394 GLN C 192 191 SER D Protein S 1 FT #SUB 395 394 GLN C 195 194 LEU D Protein S 6 FT #SUB 397 396 GLU C 352 351 PHE D Protein S 1 FT #SUB 398 397 VAL C 94 93 TRP D Protein S 2 FT #SUB 398 397 VAL C 98 97 GLY D Protein S 1 FT #SUB 398 397 VAL C 106 105 THR D Protein A 4 FT #SUB 398 397 VAL C 107 106 TYR D Protein A 8 FT #SUB 398 397 VAL C 108 107 PRO D Protein A 3 FT #SUB 400 399 ALA C 108 107 PRO D Protein A 3 FT #SUB 403 402 PHE C 107 106 TYR D Protein S 2 FT #SUB 403 402 PHE C 108 107 PRO D Protein S 4 FT #SUB 403 402 PHE C 112 111 LEU D Protein S 2 FT #SUB 413 412 ASN C 256 255 ARG D Protein S 1 FT #SUB 414 413 SER C 257 256 GLU D Protein B 2 FT #SUB 415 414 SER C 237 236 LEU D Protein B 1 FT #SUB 415 414 SER C 255 254 THR D Protein S 3 FT #SUB 415 414 SER C 257 256 GLU D Protein A 8 FT #SUB 416 415 THR C 189 188 GLU D Protein S 4 FT #SUB 416 415 THR C 191 190 LYS D Protein A 5 FT #SUB 416 415 THR C 197 196 GLY D Protein S 1 FT #SUB 416 415 THR C 199 198 VAL D Protein S 1 FT #SUB 416 415 THR C 259 258 PHE D Protein S 1 FT #SUB 417 416 THR C 191 190 LYS D Protein B 2 FT #SUB 417 416 THR C 196 195 GLY D Protein B 2 FT #SUB 417 416 THR C 197 196 GLY D Protein B 2 FT #SUB 418 417 ALA C 110 109 GLN D Protein S 1 FT #SUB 418 417 ALA C 195 194 LEU D Protein A 5 FT #SUB 418 417 ALA C 196 195 GLY D Protein B 5 FT #SUB 420 419 THR C 196 195 GLY D Protein B 1 FT #SUB 422 421 SER C 194 193 HIS D Protein A 3 FT #SUB 422 421 SER C 195 194 LEU D Protein S 2 FT #SUB 423 422 THR C 194 193 HIS D Protein A 5 FT #SUB 423 422 THR C 288 287 GLY D Protein S 1 FT #SUB 423 422 THR C 318 317 SER D Protein S 4 FT #SUB 426 425 GLY C 323 322 LYS D Protein B 1 FT #SUB 427 426 GLN C 288 287 GLY D Protein S 1 FT #SUB 427 426 GLN C 319 318 PHE D Protein S 2 FT #SUB 427 426 GLN C 320 319 ASN D Protein A 4 FT #SUB 427 426 GLN C 323 322 LYS D Protein B 2 FT #SUB 427 426 GLN C 324 323 HIS D Protein S 6 FT #SUB 428 427 PHE C 317 316 PRO D Protein S 1 FT #SUB 428 427 PHE C 318 317 SER D Protein S 3 FT #HET 90 89 TYR C 8 463 GLV C S 5 FT #HET 92 91 SER C 8 463 GLV C A 6 FT #HET 93 92 GLY C 8 463 GLV C B 3 FT #HET 94 93 TRP C 8 463 GLV C A 6 FT #HET 109 108 ASP C 7 453 MG C S 1 FT #HET 109 108 ASP C 8 463 GLV C S 1 FT #HET 109 108 ASP C 9 473 SIN C S 2 FT #HET 154 153 ASP C 7 453 MG C S 3 FT #HET 154 153 ASP C 8 463 GLV C S 4 FT #HET 181 180 HIS C 8 463 GLV C S 1 FT #HET 192 191 SER C 9 473 SIN C A 5 FT #HET 193 192 GLY C 9 473 SIN C B 5 FT #HET 194 193 HIS C 9 473 SIN C S 6 FT #HET 229 228 ARG C 8 463 GLV C S 2 FT #HET 229 228 ARG C 9 473 SIN C S 5 FT #HET 284 283 TRP C 8 463 GLV C S 2 FT #HET 286 285 GLU C 9 473 SIN C S 5 FT #HET 314 313 ASN C 9 473 SIN C S 5 FT #HET 316 315 SER C 9 473 SIN C A 6 FT #HET 318 317 SER C 9 473 SIN C S 3 FT #HET 348 347 THR C 8 463 GLV C A 5 FT #HET 348 347 THR C 9 473 SIN C S 6 FT DISORDER 1 1 FT DISORDER 429 429 CC SEQUENCE 427 AA (ATOM); CC ASVVGTPKSA EQIQQEWDTN PRWKDVTRTY SAEDVVALQG SVVEEHTLAR RGAEVLWEQL CC HDLEWVNALG ALTGNMAVQQ VRAGLKAIYL SGWQVAGDAN LSGHTYPDQS LYPANSVPQV CC VRRINNALQR ADQIAKIEGD TSVENWLAPI VADGEAGFGG ALNVYELQKA LIAAGVAGSH CC WEDQLASEKK SGHLGGKVLI PTQQHIRTLT SARLAADVAD VPTVVIARTD AEAATLITSD CC VDERDQPFIT GERTREGFYR TKNGIEPCIA RAKAYAPFAD LIWMETGTPD LEAARQFSEA CC VKAEYPDQML AYNCSPSFNW KKHLDDATIA KFQKELAAMG FKFQFITLAG FHALNYSMFD CC LAYGYAQNQM SAYVELQERE FAAEERGYTA TKHQREVGAG YFDRIATTVD PNSSTTALTG CC STEEGQF CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA CC ATOM -ASVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA CC ************************************************* CC SEQRES RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA CC ATOM RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA CC ************************************************** CC SEQRES NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP CC ATOM NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP CC ************************************************** CC SEQRES IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKSGHLGGKVL CC ATOM IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKSGHLGGKVL CC ************************************************** CC SEQRES IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI CC ATOM IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI CC ************************************************** CC SEQRES TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE CC ATOM TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE CC ************************************************** CC SEQRES AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA CC ATOM AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA CC ************************************************** CC SEQRES GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA CC ATOM GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA CC ************************************************** CC SEQRES GYFDRIATTVDPNSSTTALTGSTEEGQFH CC ATOM GYFDRIATTVDPNSSTTALTGSTEEGQF- CC **************************** SQ SEQUENCE 429 AA; MW; CN; MASVVGTPKS AEQIQQEWDT NPRWKDVTRT YSAEDVVALQ GSVVEEHTLA RRGAEVLWEQ LHDLEWVNAL GALTGNMAVQ QVRAGLKAIY LSGWQVAGDA NLSGHTYPDQ SLYPANSVPQ VVRRINNALQ RADQIAKIEG DTSVENWLAP IVADGEAGFG GALNVYELQK ALIAAGVAGS HWEDQLASEK KSGHLGGKVL IPTQQHIRTL TSARLAADVA DVPTVVIART DAEAATLITS DVDERDQPFI TGERTREGFY RTKNGIEPCI ARAKAYAPFA DLIWMETGTP DLEAARQFSE AVKAEYPDQM LAYNCSPSFN WKKHLDDATI AKFQKELAAM GFKFQFITLA GFHALNYSMF DLAYGYAQNQ MSAYVELQER EFAAEERGYT ATKHQREVGA GYFDRIATTV DPNSSTTALT GSTEEGQFH // ID 1F8ID STANDARD; PRT; 429 AA. DT CONVERTED FROM PDB (SEQRES) 1F8I DE ISOCITRATE LYASE OS Mycobacterium tuberculosis H37Rv CC EXPDTA X-RAY DIFFRACTION CC RESOLU 2.250 CC R-Factor 0.166 FT #SUB 2 1 ALA D 59 58 GLU A Protein B 2 FT #SUB 3 2 SER D 52 51 ARG A Protein A 4 FT #SUB 3 2 SER D 55 54 GLU A Protein S 1 FT #SUB 3 2 SER D 56 55 VAL A Protein S 1 FT #SUB 5 4 VAL D 48 47 THR A Protein S 1 FT #SUB 5 4 VAL D 52 51 ARG A Protein A 3 FT #SUB 5 4 VAL D 55 54 GLU A Protein S 2 FT #SUB 6 5 GLY D 48 47 THR A Protein B 1 FT #SUB 31 30 TYR D 409 408 THR A Protein S 2 FT #SUB 35 34 ASP D 409 408 THR A Protein S 1 FT #SUB 37 36 VAL D 137 136 LYS A Protein A 4 FT #SUB 38 37 ALA D 137 136 LYS A Protein B 1 FT #SUB 38 37 ALA D 138 137 ILE A Protein B 1 FT #SUB 38 37 ALA D 405 404 ARG A Protein S 2 FT #SUB 39 38 LEU D 402 401 TYR A Protein A 8 FT #SUB 39 38 LEU D 405 404 ARG A Protein S 1 FT #SUB 39 38 LEU D 406 405 ILE A Protein S 1 FT #SUB 41 40 GLY D 133 132 ASP A Protein B 2 FT #SUB 41 40 GLY D 137 136 LYS A Protein B 8 FT #SUB 42 41 SER D 133 132 ASP A Protein A 9 FT #SUB 43 42 VAL D 52 51 ARG A Protein S 1 FT #SUB 43 42 VAL D 133 132 ASP A Protein B 1 FT #SUB 43 42 VAL D 148 147 LEU A Protein S 3 FT #SUB 44 43 VAL D 48 47 THR A Protein B 1 FT #SUB 45 44 GLU D 48 47 THR A Protein B 3 FT #SUB 45 44 GLU D 49 48 LEU A Protein S 5 FT #SUB 45 44 GLU D 123 122 ARG A Protein S 7 FT #SUB 45 44 GLU D 130 129 GLN A Protein S 5 FT #SUB 46 45 GLU D 46 45 GLU A Protein A 5 FT #SUB 46 45 GLU D 48 47 THR A Protein A 4 FT #SUB 48 47 THR D 6 5 GLY A Protein S 1 FT #SUB 48 47 THR D 44 43 VAL A Protein S 1 FT #SUB 48 47 THR D 45 44 GLU A Protein S 3 FT #SUB 48 47 THR D 46 45 GLU A Protein S 4 FT #SUB 49 48 LEU D 45 44 GLU A Protein S 5 FT #SUB 51 50 ARG D 5 4 VAL A Protein S 1 FT #SUB 52 51 ARG D 3 2 SER A Protein S 3 FT #SUB 52 51 ARG D 5 4 VAL A Protein S 4 FT #SUB 52 51 ARG D 43 42 VAL A Protein S 3 FT #SUB 55 54 GLU D 3 2 SER A Protein S 1 FT #SUB 55 54 GLU D 5 4 VAL A Protein S 3 FT #SUB 59 58 GLU D 2 1 ALA A Protein S 2 FT #SUB 123 122 ARG D 45 44 GLU A Protein S 7 FT #SUB 130 129 GLN D 45 44 GLU A Protein S 5 FT #SUB 133 132 ASP D 41 40 GLY A Protein S 2 FT #SUB 133 132 ASP D 42 41 SER A Protein S 9 FT #SUB 133 132 ASP D 43 42 VAL A Protein S 1 FT #SUB 137 136 LYS D 37 36 VAL A Protein S 4 FT #SUB 137 136 LYS D 41 40 GLY A Protein S 8 FT #SUB 138 137 ILE D 38 37 ALA A Protein S 1 FT #SUB 148 147 LEU D 43 42 VAL A Protein S 3 FT #SUB 163 162 LEU D 403 402 PHE A Protein S 1 FT #SUB 163 162 LEU D 406 405 ILE A Protein S 2 FT #SUB 166 165 TYR D 406 405 ILE A Protein S 3 FT #SUB 167 166 GLU D 403 402 PHE A Protein S 2 FT #SUB 208 207 ARG D 410 409 VAL A Protein B 1 FT #SUB 208 207 ARG D 411 410 ASP A Protein S 2 FT #SUB 212 211 SER D 410 409 VAL A Protein A 2 FT #SUB 215 214 LEU D 409 408 THR A Protein S 2 FT #SUB 215 214 LEU D 410 409 VAL A Protein S 1 FT #SUB 402 401 TYR D 39 38 LEU A Protein S 7 FT #SUB 403 402 PHE D 163 162 LEU A Protein B 1 FT #SUB 403 402 PHE D 167 166 GLU A Protein S 2 FT #SUB 405 404 ARG D 38 37 ALA A Protein S 2 FT #SUB 405 404 ARG D 39 38 LEU A Protein S 1 FT #SUB 406 405 ILE D 39 38 LEU A Protein S 1 FT #SUB 406 405 ILE D 163 162 LEU A Protein S 2 FT #SUB 406 405 ILE D 166 165 TYR A Protein S 3 FT #SUB 409 408 THR D 31 30 TYR A Protein A 2 FT #SUB 409 408 THR D 35 34 ASP A Protein S 1 FT #SUB 409 408 THR D 215 214 LEU A Protein S 3 FT #SUB 410 409 VAL D 208 207 ARG A Protein S 1 FT #SUB 410 409 VAL D 212 211 SER A Protein S 2 FT #SUB 410 409 VAL D 215 214 LEU A Protein S 1 FT #SUB 411 410 ASP D 208 207 ARG A Protein S 5 FT #SUB 102 101 LEU D 116 115 ASN B Protein B 1 FT #SUB 107 106 TYR D 167 166 GLU B Protein S 11 FT #SUB 110 109 GLN D 163 162 LEU B Protein S 1 FT #SUB 111 110 SER D 164 163 ASN B Protein B 1 FT #SUB 112 111 LEU D 163 162 LEU B Protein S 2 FT #SUB 112 111 LEU D 164 163 ASN B Protein A 2 FT #SUB 114 113 PRO D 116 115 ASN B Protein S 5 FT #SUB 116 115 ASN D 102 101 LEU B Protein S 1 FT #SUB 116 115 ASN D 114 113 PRO B Protein S 4 FT #SUB 160 159 GLY D 188 187 SER B Protein B 4 FT #SUB 161 160 GLY D 188 187 SER B Protein B 5 FT #SUB 161 160 GLY D 189 188 GLU B Protein B 1 FT #SUB 163 162 LEU D 110 109 GLN B Protein S 1 FT #SUB 163 162 LEU D 112 111 LEU B Protein S 1 FT #SUB 164 163 ASN D 111 110 SER B Protein S 1 FT #SUB 164 163 ASN D 112 111 LEU B Protein S 1 FT #SUB 164 163 ASN D 188 187 SER B Protein S 1 FT #SUB 167 166 GLU D 107 106 TYR B Protein S 11 FT #SUB 188 187 SER D 160 159 GLY B Protein A 3 FT #SUB 188 187 SER D 161 160 GLY B Protein A 4 FT #SUB 188 187 SER D 164 163 ASN B Protein B 1 FT #SUB 208 207 ARG D 257 256 GLU B Protein S 1 FT #SUB 241 240 ASP D 254 253 ARG B Protein S 1 FT #SUB 242 241 VAL D 255 254 THR B Protein S 1 FT #SUB 242 241 VAL D 256 255 ARG B Protein S 2 FT #SUB 242 241 VAL D 258 257 GLY B Protein S 3 FT #SUB 254 253 ARG D 241 240 ASP B Protein S 1 FT #SUB 256 255 ARG D 242 241 VAL B Protein B 1 FT #SUB 257 256 GLU D 208 207 ARG B Protein S 1 FT #SUB 257 256 GLU D 242 241 VAL B Protein B 1 FT #SUB 258 257 GLY D 242 241 VAL B Protein B 1 FT #SUB 260 259 TYR D 260 259 TYR B Protein S 1 FT #SUB 66 65 TRP D 370 369 GLN C Protein S 4 FT #SUB 68 67 ASN D 366 365 TYR C Protein S 5 FT #SUB 68 67 ASN D 370 369 GLN C Protein S 1 FT #SUB 69 68 ALA D 366 365 TYR C Protein B 7 FT #SUB 70 69 LEU D 363 362 ALA C Protein S 1 FT #SUB 70 69 LEU D 366 365 TYR C Protein S 9 FT #SUB 74 73 THR D 99 98 ASP C Protein A 8 FT #SUB 74 73 THR D 355 354 LEU C Protein S 2 FT #SUB 75 74 GLY D 99 98 ASP C Protein B 3 FT #SUB 76 75 ASN D 98 97 GLY C Protein S 1 FT #SUB 76 75 ASN D 99 98 ASP C Protein A 17 FT #SUB 76 75 ASN D 352 351 PHE C Protein S 2 FT #SUB 76 75 ASN D 355 354 LEU C Protein S 1 FT #SUB 76 75 ASN D 356 355 ASN C Protein A 9 FT #SUB 77 76 MET D 359 358 MET C Protein B 1 FT #SUB 80 79 GLN D 356 355 ASN C Protein S 10 FT #SUB 80 79 GLN D 360 359 PHE C Protein S 4 FT #SUB 81 80 GLN D 359 358 MET C Protein S 4 FT #SUB 81 80 GLN D 363 362 ALA C Protein B 1 FT #SUB 83 82 ARG D 360 359 PHE C Protein S 1 FT #SUB 84 83 ALA D 363 362 ALA C Protein S 2 FT #SUB 84 83 ALA D 364 363 TYR C Protein S 2 FT #SUB 84 83 ALA D 367 366 ALA C Protein B 1 FT #SUB 86 85 LEU D 366 365 TYR C Protein S 2 FT #SUB 86 85 LEU D 367 366 ALA C Protein S 1 FT #SUB 94 93 TRP D 394 393 HIS C Protein S 7 FT #SUB 94 93 TRP D 395 394 GLN C Protein S 4 FT #SUB 94 93 TRP D 398 397 VAL C Protein S 2 FT #SUB 98 97 GLY D 76 75 ASN C Protein B 1 FT #SUB 98 97 GLY D 124 123 ARG C Protein B 1 FT #SUB 98 97 GLY D 398 397 VAL C Protein B 1 FT #SUB 99 98 ASP D 74 73 THR C Protein S 8 FT #SUB 99 98 ASP D 75 74 GLY C Protein S 4 FT #SUB 99 98 ASP D 76 75 ASN C Protein S 18 FT #SUB 99 98 ASP D 124 123 ARG C Protein A 5 FT #SUB 104 103 GLY D 124 123 ARG C Protein B 8 FT #SUB 104 103 GLY D 127 126 ASN C Protein B 5 FT #SUB 105 104 HIS D 124 123 ARG C Protein B 3 FT #SUB 105 104 HIS D 127 126 ASN C Protein S 7 FT #SUB 106 105 THR D 124 123 ARG C Protein A 6 FT #SUB 106 105 THR D 128 127 ALA C Protein S 2 FT #SUB 106 105 THR D 131 130 ARG C Protein A 6 FT #SUB 106 105 THR D 398 397 VAL C Protein A 4 FT #SUB 107 106 TYR D 131 130 ARG C Protein S 2 FT #SUB 107 106 TYR D 398 397 VAL C Protein B 8 FT #SUB 107 106 TYR D 403 402 PHE C Protein S 2 FT #SUB 108 107 PRO D 398 397 VAL C Protein A 3 FT #SUB 108 107 PRO D 400 399 ALA C Protein S 3 FT #SUB 108 107 PRO D 403 402 PHE C Protein S 4 FT #SUB 110 109 GLN D 418 417 ALA C Protein S 1 FT #SUB 112 111 LEU D 403 402 PHE C Protein S 2 FT #SUB 124 123 ARG D 98 97 GLY C Protein S 1 FT #SUB 124 123 ARG D 99 98 ASP C Protein S 5 FT #SUB 124 123 ARG D 104 103 GLY C Protein A 8 FT #SUB 124 123 ARG D 105 104 HIS C Protein S 3 FT #SUB 124 123 ARG D 106 105 THR C Protein S 6 FT #SUB 127 126 ASN D 104 103 GLY C Protein S 4 FT #SUB 127 126 ASN D 105 104 HIS C Protein S 7 FT #SUB 128 127 ALA D 106 105 THR C Protein A 2 FT #SUB 131 130 ARG D 105 104 HIS C Protein S 1 FT #SUB 131 130 ARG D 106 105 THR C Protein S 5 FT #SUB 131 130 ARG D 107 106 TYR C Protein S 2 FT #SUB 189 188 GLU D 416 415 THR C Protein S 4 FT #SUB 191 190 LYS D 416 415 THR C Protein S 5 FT #SUB 191 190 LYS D 417 416 THR C Protein S 2 FT #SUB 192 191 SER D 395 394 GLN C Protein S 1 FT #SUB 194 193 HIS D 422 421 SER C Protein B 3 FT #SUB 194 193 HIS D 423 422 THR C Protein A 5 FT #SUB 195 194 LEU D 395 394 GLN C Protein S 6 FT #SUB 195 194 LEU D 418 417 ALA C Protein A 5 FT #SUB 195 194 LEU D 422 421 SER C Protein A 2 FT #SUB 196 195 GLY D 417 416 THR C Protein B 2 FT #SUB 196 195 GLY D 418 417 ALA C Protein B 5 FT #SUB 196 195 GLY D 420 419 THR C Protein B 1 FT #SUB 197 196 GLY D 416 415 THR C Protein B 1 FT #SUB 197 196 GLY D 417 416 THR C Protein B 2 FT #SUB 199 198 VAL D 416 415 THR C Protein S 1 FT #SUB 237 236 LEU D 415 414 SER C Protein S 1 FT #SUB 255 254 THR D 415 414 SER C Protein S 3 FT #SUB 256 255 ARG D 413 412 ASN C Protein S 1 FT #SUB 257 256 GLU D 414 413 SER C Protein S 2 FT #SUB 257 256 GLU D 415 414 SER C Protein S 8 FT #SUB 259 258 PHE D 416 415 THR C Protein S 1 FT #SUB 288 287 GLY D 423 422 THR C Protein B 1 FT #SUB 288 287 GLY D 427 426 GLN C Protein B 1 FT #SUB 315 314 CYS D 371 370 MET C Protein S 3 FT #SUB 317 316 PRO D 374 373 TYR C Protein S 6 FT #SUB 317 316 PRO D 378 377 GLN C Protein B 1 FT #SUB 317 316 PRO D 394 393 HIS C Protein B 2 FT #SUB 317 316 PRO D 428 427 PHE C Protein B 1 FT #SUB 318 317 SER D 394 393 HIS C Protein A 6 FT #SUB 318 317 SER D 423 422 THR C Protein A 4 FT #SUB 318 317 SER D 428 427 PHE C Protein B 3 FT #SUB 319 318 PHE D 378 377 GLN C Protein B 4 FT #SUB 319 318 PHE D 427 426 GLN C Protein B 2 FT #SUB 320 319 ASN D 378 377 GLN C Protein B 1 FT #SUB 320 319 ASN D 382 381 PHE C Protein S 4 FT #SUB 320 319 ASN D 427 426 GLN C Protein A 4 FT #SUB 321 320 TRP D 371 370 MET C Protein S 4 FT #SUB 321 320 TRP D 378 377 GLN C Protein A 3 FT #SUB 322 321 LYS D 375 374 VAL C Protein S 2 FT #SUB 322 321 LYS D 379 378 GLU C Protein S 6 FT #SUB 323 322 LYS D 426 425 GLY C Protein S 1 FT #SUB 323 322 LYS D 427 426 GLN C Protein S 2 FT #SUB 324 323 HIS D 427 426 GLN C Protein S 6 FT #SUB 330 329 ILE D 371 370 MET C Protein A 3 FT #SUB 330 329 ILE D 372 371 SER C Protein S 1 FT #SUB 330 329 ILE D 375 374 VAL C Protein S 1 FT #SUB 331 330 ALA D 372 371 SER C Protein A 3 FT #SUB 334 333 GLN D 366 365 TYR C Protein S 5 FT #SUB 334 333 GLN D 370 369 GLN C Protein S 6 FT #SUB 334 333 GLN D 371 370 MET C Protein S 2 FT #SUB 345 344 GLN D 366 365 TYR C Protein B 1 FT #SUB 347 346 ILE D 366 365 TYR C Protein S 3 FT #SUB 347 346 ILE D 371 370 MET C Protein S 3 FT #SUB 347 346 ILE D 374 373 TYR C Protein S 5 FT #SUB 349 348 LEU D 394 393 HIS C Protein S 5 FT #SUB 351 350 GLY D 359 358 MET C Protein B 2 FT #SUB 352 351 PHE D 76 75 ASN C Protein S 2 FT #SUB 352 351 PHE D 391 390 ALA C Protein S 1 FT #SUB 352 351 PHE D 394 393 HIS C Protein S 4 FT #SUB 352 351 PHE D 397 396 GLU C Protein S 1 FT #SUB 353 352 HIS D 374 373 TYR C Protein S 3 FT #SUB 353 352 HIS D 381 380 GLU C Protein A 12 FT #SUB 353 352 HIS D 391 390 ALA C Protein S 2 FT #SUB 353 352 HIS D 392 391 THR C Protein S 1 FT #SUB 353 352 HIS D 394 393 HIS C Protein S 4 FT #SUB 354 353 ALA D 358 357 SER C Protein B 2 FT #SUB 354 353 ALA D 359 358 MET C Protein S 1 FT #SUB 355 354 LEU D 74 73 THR C Protein S 2 FT #SUB 355 354 LEU D 76 75 ASN C Protein S 1 FT #SUB 355 354 LEU D 77 76 MET C Protein S 1 FT #SUB 356 355 ASN D 76 75 ASN C Protein S 8 FT #SUB 356 355 ASN D 80 79 GLN C Protein A 10 FT #SUB 356 355 ASN D 389 388 TYR C Protein A 4 FT #SUB 356 355 ASN D 391 390 ALA C Protein S 1 FT #SUB 357 356 TYR D 377 376 LEU C Protein S 1 FT #SUB 357 356 TYR D 380 379 ARG C Protein S 2 FT #SUB 357 356 TYR D 381 380 GLU C Protein S 2 FT #SUB 357 356 TYR D 384 383 ALA C Protein S 1 FT #SUB 357 356 TYR D 387 386 ARG C Protein S 1 FT #SUB 357 356 TYR D 389 388 TYR C Protein A 7 FT #SUB 358 357 SER D 354 353 ALA C Protein S 2 FT #SUB 358 357 SER D 358 357 SER C Protein S 4 FT #SUB 359 358 MET D 77 76 MET C Protein S 2 FT #SUB 359 358 MET D 81 80 GLN C Protein S 4 FT #SUB 359 358 MET D 351 350 GLY C Protein S 2 FT #SUB 359 358 MET D 354 353 ALA C Protein S 1 FT #SUB 360 359 PHE D 80 79 GLN C Protein A 5 FT #SUB 360 359 PHE D 83 82 ARG C Protein S 1 FT #SUB 360 359 PHE D 84 83 ALA C Protein B 1 FT #SUB 360 359 PHE D 387 386 ARG C Protein S 1 FT #SUB 360 359 PHE D 389 388 TYR C Protein S 10 FT #SUB 361 360 ASP D 387 386 ARG C Protein S 3 FT #SUB 362 361 LEU D 70 69 LEU C Protein S 1 FT #SUB 362 361 LEU D 350 349 ALA C Protein S 1 FT #SUB 363 362 ALA D 70 69 LEU C Protein B 1 FT #SUB 363 362 ALA D 81 80 GLN C Protein S 1 FT #SUB 363 362 ALA D 84 83 ALA C Protein A 2 FT #SUB 363 362 ALA D 86 85 LEU C Protein S 1 FT #SUB 364 363 TYR D 84 83 ALA C Protein B 2 FT #SUB 364 363 TYR D 387 386 ARG C Protein S 5 FT #SUB 366 365 TYR D 68 67 ASN C Protein S 4 FT #SUB 366 365 TYR D 69 68 ALA C Protein S 7 FT #SUB 366 365 TYR D 70 69 LEU C Protein S 9 FT #SUB 366 365 TYR D 86 85 LEU C Protein S 1 FT #SUB 366 365 TYR D 334 333 GLN C Protein S 5 FT #SUB 366 365 TYR D 345 344 GLN C Protein S 1 FT #SUB 366 365 TYR D 347 346 ILE C Protein S 4 FT #SUB 367 366 ALA D 84 83 ALA C Protein S 1 FT #SUB 367 366 ALA D 86 85 LEU C Protein S 1 FT #SUB 370 369 GLN D 66 65 TRP C Protein S 3 FT #SUB 370 369 GLN D 68 67 ASN C Protein S 1 FT #SUB 370 369 GLN D 331 330 ALA C Protein S 1 FT #SUB 370 369 GLN D 334 333 GLN C Protein S 5 FT #SUB 371 370 MET D 315 314 CYS C Protein S 3 FT #SUB 371 370 MET D 321 320 TRP C Protein S 3 FT #SUB 371 370 MET D 330 329 ILE C Protein A 3 FT #SUB 371 370 MET D 334 333 GLN C Protein S 2 FT #SUB 371 370 MET D 347 346 ILE C Protein S 2 FT #SUB 372 371 SER D 330 329 ILE C Protein B 1 FT #SUB 372 371 SER D 331 330 ALA C Protein S 3 FT #SUB 374 373 TYR D 317 316 PRO C Protein S 6 FT #SUB 374 373 TYR D 347 346 ILE C Protein S 4 FT #SUB 374 373 TYR D 353 352 HIS C Protein S 4 FT #SUB 375 374 VAL D 322 321 LYS C Protein S 2 FT #SUB 375 374 VAL D 330 329 ILE C Protein S 1 FT #SUB 377 376 LEU D 354 353 ALA C Protein S 1 FT #SUB 377 376 LEU D 357 356 TYR C Protein S 1 FT #SUB 378 377 GLN D 317 316 PRO C Protein S 1 FT #SUB 378 377 GLN D 319 318 PHE C Protein S 3 FT #SUB 378 377 GLN D 321 320 TRP C Protein S 4 FT #SUB 379 378 GLU D 322 321 LYS C Protein S 6 FT #SUB 380 379 ARG D 357 356 TYR C Protein A 3 FT #SUB 381 380 GLU D 353 352 HIS C Protein S 11 FT #SUB 381 380 GLU D 357 356 TYR C Protein S 3 FT #SUB 382 381 PHE D 320 319 ASN C Protein S 5 FT #SUB 384 383 ALA D 357 356 TYR C Protein S 1 FT #SUB 387 386 ARG D 357 356 TYR C Protein S 1 FT #SUB 387 386 ARG D 360 359 PHE C Protein B 2 FT #SUB 387 386 ARG D 361 360 ASP C Protein S 3 FT #SUB 387 386 ARG D 364 363 TYR C Protein A 5 FT #SUB 389 388 TYR D 356 355 ASN C Protein S 4 FT #SUB 389 388 TYR D 357 356 TYR C Protein S 6 FT #SUB 389 388 TYR D 360 359 PHE C Protein A 11 FT #SUB 391 390 ALA D 352 351 PHE C Protein B 1 FT #SUB 391 390 ALA D 353 352 HIS C Protein B 2 FT #SUB 391 390 ALA D 356 355 ASN C Protein S 1 FT #SUB 392 391 THR D 353 352 HIS C Protein B 1 FT #SUB 394 393 HIS D 94 93 TRP C Protein A 8 FT #SUB 394 393 HIS D 317 316 PRO C Protein S 2 FT #SUB 394 393 HIS D 318 317 SER C Protein S 6 FT #SUB 394 393 HIS D 349 348 LEU C Protein S 5 FT #SUB 394 393 HIS D 352 351 PHE C Protein A 4 FT #SUB 394 393 HIS D 353 352 HIS C Protein S 4 FT #SUB 395 394 GLN D 94 93 TRP C Protein S 4 FT #SUB 395 394 GLN D 192 191 SER C Protein S 1 FT #SUB 395 394 GLN D 195 194 LEU C Protein S 6 FT #SUB 397 396 GLU D 352 351 PHE C Protein S 1 FT #SUB 398 397 VAL D 94 93 TRP C Protein S 1 FT #SUB 398 397 VAL D 98 97 GLY C Protein S 1 FT #SUB 398 397 VAL D 106 105 THR C Protein A 3 FT #SUB 398 397 VAL D 107 106 TYR C Protein A 9 FT #SUB 398 397 VAL D 108 107 PRO C Protein A 4 FT #SUB 400 399 ALA D 108 107 PRO C Protein A 3 FT #SUB 403 402 PHE D 107 106 TYR C Protein S 2 FT #SUB 403 402 PHE D 108 107 PRO C Protein S 4 FT #SUB 403 402 PHE D 112 111 LEU C Protein S 2 FT #SUB 413 412 ASN D 256 255 ARG C Protein S 1 FT #SUB 414 413 SER D 257 256 GLU C Protein B 2 FT #SUB 415 414 SER D 237 236 LEU C Protein B 1 FT #SUB 415 414 SER D 255 254 THR C Protein S 3 FT #SUB 415 414 SER D 257 256 GLU C Protein A 8 FT #SUB 416 415 THR D 189 188 GLU C Protein S 4 FT #SUB 416 415 THR D 191 190 LYS C Protein A 5 FT #SUB 416 415 THR D 197 196 GLY C Protein A 3 FT #SUB 416 415 THR D 199 198 VAL C Protein S 1 FT #SUB 416 415 THR D 259 258 PHE C Protein S 1 FT #SUB 417 416 THR D 191 190 LYS C Protein B 1 FT #SUB 417 416 THR D 196 195 GLY C Protein B 3 FT #SUB 417 416 THR D 197 196 GLY C Protein B 2 FT #SUB 418 417 ALA D 195 194 LEU C Protein A 5 FT #SUB 418 417 ALA D 196 195 GLY C Protein B 5 FT #SUB 420 419 THR D 196 195 GLY C Protein B 2 FT #SUB 422 421 SER D 194 193 HIS C Protein A 3 FT #SUB 422 421 SER D 195 194 LEU C Protein A 3 FT #SUB 422 421 SER D 196 195 GLY C Protein B 2 FT #SUB 423 422 THR D 194 193 HIS C Protein A 6 FT #SUB 423 422 THR D 288 287 GLY C Protein S 1 FT #SUB 423 422 THR D 318 317 SER C Protein S 4 FT #SUB 426 425 GLY D 323 322 LYS C Protein B 1 FT #SUB 427 426 GLN D 288 287 GLY C Protein S 1 FT #SUB 427 426 GLN D 318 317 SER C Protein S 1 FT #SUB 427 426 GLN D 319 318 PHE C Protein S 3 FT #SUB 427 426 GLN D 320 319 ASN C Protein A 4 FT #SUB 427 426 GLN D 323 322 LYS C Protein B 2 FT #SUB 427 426 GLN D 324 323 HIS C Protein S 6 FT #SUB 428 427 PHE D 317 316 PRO C Protein S 1 FT #SUB 428 427 PHE D 318 317 SER C Protein S 1 FT #HET 90 89 TYR D 11 464 GLV D S 5 FT #HET 92 91 SER D 11 464 GLV D A 6 FT #HET 93 92 GLY D 11 464 GLV D B 4 FT #HET 94 93 TRP D 11 464 GLV D A 6 FT #HET 94 93 TRP D 12 474 SIN D S 1 FT #HET 109 108 ASP D 10 454 MG D S 1 FT #HET 109 108 ASP D 11 464 GLV D S 1 FT #HET 109 108 ASP D 12 474 SIN D S 2 FT #HET 154 153 ASP D 10 454 MG D S 3 FT #HET 154 153 ASP D 11 464 GLV D S 5 FT #HET 181 180 HIS D 11 464 GLV D S 1 FT #HET 192 191 SER D 12 474 SIN D A 6 FT #HET 193 192 GLY D 12 474 SIN D B 7 FT #HET 194 193 HIS D 12 474 SIN D S 8 FT #HET 229 228 ARG D 11 464 GLV D S 2 FT #HET 229 228 ARG D 12 474 SIN D S 5 FT #HET 284 283 TRP D 11 464 GLV D S 1 FT #HET 286 285 GLU D 12 474 SIN D S 5 FT #HET 314 313 ASN D 12 474 SIN D S 4 FT #HET 316 315 SER D 12 474 SIN D A 5 FT #HET 318 317 SER D 12 474 SIN D S 3 FT #HET 348 347 THR D 11 464 GLV D S 3 FT #HET 348 347 THR D 12 474 SIN D S 6 FT DISORDER 1 1 FT DISORDER 429 429 CC SEQUENCE 427 AA (ATOM); CC ASVVGTPKSA EQIQQEWDTN PRWKDVTRTY SAEDVVALQG SVVEEHTLAR RGAEVLWEQL CC HDLEWVNALG ALTGNMAVQQ VRAGLKAIYL SGWQVAGDAN LSGHTYPDQS LYPANSVPQV CC VRRINNALQR ADQIAKIEGD TSVENWLAPI VADGEAGFGG ALNVYELQKA LIAAGVAGSH CC WEDQLASEKK SGHLGGKVLI PTQQHIRTLT SARLAADVAD VPTVVIARTD AEAATLITSD CC VDERDQPFIT GERTREGFYR TKNGIEPCIA RAKAYAPFAD LIWMETGTPD LEAARQFSEA CC VKAEYPDQML AYNCSPSFNW KKHLDDATIA KFQKELAAMG FKFQFITLAG FHALNYSMFD CC LAYGYAQNQM SAYVELQERE FAAEERGYTA TKHQREVGAG YFDRIATTVD PNSSTTALTG CC STEEGQF CC !---- CC ALIGNMENT OF SEQRES AND ATOMRES CC SEQRES MASVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA CC ATOM -ASVVGTPKSAEQIQQEWDTNPRWKDVTRTYSAEDVVALQGSVVEEHTLA CC ************************************************* CC SEQRES RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA CC ATOM RRGAEVLWEQLHDLEWVNALGALTGNMAVQQVRAGLKAIYLSGWQVAGDA CC ************************************************** CC SEQRES NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP CC ATOM NLSGHTYPDQSLYPANSVPQVVRRINNALQRADQIAKIEGDTSVENWLAP CC ************************************************** CC SEQRES IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKSGHLGGKVL CC ATOM IVADGEAGFGGALNVYELQKALIAAGVAGSHWEDQLASEKKSGHLGGKVL CC ************************************************** CC SEQRES IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI CC ATOM IPTQQHIRTLTSARLAADVADVPTVVIARTDAEAATLITSDVDERDQPFI CC ************************************************** CC SEQRES TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE CC ATOM TGERTREGFYRTKNGIEPCIARAKAYAPFADLIWMETGTPDLEAARQFSE CC ************************************************** CC SEQRES AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA CC ATOM AVKAEYPDQMLAYNCSPSFNWKKHLDDATIAKFQKELAAMGFKFQFITLA CC ************************************************** CC SEQRES GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA CC ATOM GFHALNYSMFDLAYGYAQNQMSAYVELQEREFAAEERGYTATKHQREVGA CC ************************************************** CC SEQRES GYFDRIATTVDPNSSTTALTGSTEEGQFH CC ATOM GYFDRIATTVDPNSSTTALTGSTEEGQF- CC **************************** SQ SEQUENCE 429 AA; MW; CN; MASVVGTPKS AEQIQQEWDT NPRWKDVTRT YSAEDVVALQ GSVVEEHTLA RRGAEVLWEQ LHDLEWVNAL GALTGNMAVQ QVRAGLKAIY LSGWQVAGDA NLSGHTYPDQ SLYPANSVPQ VVRRINNALQ RADQIAKIEG DTSVENWLAP IVADGEAGFG GALNVYELQK ALIAAGVAGS HWEDQLASEK KSGHLGGKVL IPTQQHIRTL TSARLAADVA DVPTVVIART DAEAATLITS DVDERDQPFI TGERTREGFY RTKNGIEPCI ARAKAYAPFA DLIWMETGTP DLEAARQFSE AVKAEYPDQM LAYNCSPSFN WKKHLDDATI AKFQKELAAM GFKFQFITLA GFHALNYSMF DLAYGYAQNQ MSAYVELQER EFAAEERGYT ATKHQREVGA GYFDRIATTV DPNSSTTALT GSTEEGQFH //