ID	1E8ZA	STANDARD;	PRT;	966	AA.
DT	CONVERTED FROM PDB (SEQRES) 1E8Z
DE	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT
OS	HOMO SAPIENS
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.400
CC	R-Factor	0.232
FT	#HET	662	 804 	MET	A	1	3001 	STU	A	S	2
FT	#HET	664	 806 	SER	A	1	3001 	STU	A	S	5
FT	#HET	665	 807 	LYS	A	1	3001 	STU	A	S	2
FT	#HET	668	 810 	PRO	A	1	3001 	STU	A	S	1
FT	#HET	670	 812 	TRP	A	1	3001 	STU	A	S	6
FT	#HET	689	 831 	ILE	A	1	3001 	STU	A	S	2
FT	#HET	691	 833 	LYS	A	1	3001 	STU	A	S	3
FT	#HET	725	 867 	TYR	A	1	3001 	STU	A	S	5
FT	#HET	737	 879 	ILE	A	1	3001 	STU	A	S	5
FT	#HET	738	 880 	GLU	A	1	3001 	STU	A	B	4
FT	#HET	739	 881 	ILE	A	1	3001 	STU	A	B	2
FT	#HET	740	 882 	VAL	A	1	3001 	STU	A	A	8
FT	#HET	743	 885 	ALA	A	1	3001 	STU	A	B	3
FT	#HET	745	 887 	THR	A	1	3001 	STU	A	S	1
FT	#HET	808	 950 	ASP	A	1	3001 	STU	A	B	1
FT	#HET	811	 953 	MET	A	1	3001 	STU	A	S	8
FT	#HET	821	 963 	ILE	A	1	3001 	STU	A	S	3
FT	#HET	822	 964 	ASP	A	1	3001 	STU	A	A	18
FT	DISORDER	1	1
FT	DISORDER	113	126
FT	DISORDER	181	214
FT	DISORDER	294	317
FT	DISORDER	348	354
FT	DISORDER	381	382
FT	DISORDER	387	401
FT	DISORDER	759	759
FT	DISORDER	826	838
FT	DISORDER	951	966
CC	Miss-SC	1
CC	SEQUENCE	839 AA (ATOM);
CC	SEESQAFQRQ LTALIGYDVT DVSNVHDDEL EFTRRGLVTP RMAEVASRDP KLYAMHPWVT
CC	SKPLPEYLWK KIANNCIFIV IHRSTTSQTI KVSPDDTPGA ILQSFFTKMA KDFVLRVCGR
CC	DEYLVGETPI KNFQWVRHCL KNGEEIHVVL DTPPDPALDE VRKEECDRKF RVKIRGIDIP
CC	VLPRNTDLTV FVEANIQHGQ QVLCQRRTSP KPFTEEVLWN VWLEFSIKIK DLPKGALLNL
CC	QIYCLLYYVN LLLIDHRFLL RRGEYVLHMW QISGFNADKL TSATNPDKEN SMSISILLDN
CC	HPIARAEMPN QLRKQLEAII ATDPLNPLTA EDKELLWHFR YESLKHPKAY PKLFSSVKWG
CC	QQEIVAKTYQ LLARREVWDQ SALDVGLTMQ LLDCNFSDEN VRAIAVQKLE SLEDDDVLHY
CC	LLQLVQAVKF EPYHDSALAR FLLKRGLRNK RIGHFLFWFL RSEIAQSRHY QQRFAVILEA
CC	YLRGCGTAML HDFTQQVQVI EMLQKVTLDI KSLSAEKYDV SSQVISQLKQ KLENLQNSQL
CC	PESFRVPYDP GLKAGALAIE KCKVMASKKK PLWLEFKCAD PTALSNETIG IIFKHGDDLR
CC	QDMLILQILR IMESIWETES LDLCLLPYGC ISTGDKIGMI EIVKDATTIA KIQQSTVGNT
CC	GFKDEVLNHW LKEKSPTEEK FQAAVERFVY SCAGYCVATF VLGIGDRHND NIMITETGNL
CC	FHIDFGHERV PFVLTPDFLF VMGTSGKKTS PHFQKFQDIC VKAYLALRHH TNLLIILFSM
CC	MLMTGMPQLT SKEDIEYIRD ALTVGKNEED AKKYFLDQIE VCRDKGWTVQ FNWFLHLVL
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	ATOM   -SEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRD
CC	        *************************************************
CC	SEQRES PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	ATOM   PKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPG
CC	       **************************************************
CC	SEQRES AILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQW
CC	ATOM   AILQSFFTKMAK--------------DFVLRVCGRDEYLVGETPIKNFQW
CC	       ************              ************************
CC	SEQRES VRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIH
CC	ATOM   VRHCLKNGEEIHVVLDTPPDPALDEVRKEE--------------------
CC	       ******************************                    
CC	SEQRES GKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	ATOM   --------------CDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQ
CC	                     ************************************
CC	SEQRES VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALS
CC	ATOM   VLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC-------
CC	       *******************************************       
CC	SEQRES SKASAESPSSESKGKVRLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGE
CC	ATOM   -----------------LLYYVNLLLIDHRFLLRRGEYVLHMWQISG---
CC	                        ******************************   
CC	SEQRES DQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDR
CC	ATOM   ----FNADKLTSATNPDKENSMSISILLDN--HPIA--------------
CC	           **************************  ****              
CC	SEQRES VRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	ATOM   -RAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKL
CC	        *************************************************
CC	SEQRES FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	ATOM   FSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA
CC	       **************************************************
CC	SEQRES IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	ATOM   IAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIG
CC	       **************************************************
CC	SEQRES HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	ATOM   HFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEML
CC	       **************************************************
CC	SEQRES QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	ATOM   QKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLK
CC	       **************************************************
CC	SEQRES AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	ATOM   AGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDM
CC	       **************************************************
CC	SEQRES LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	ATOM   LILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQ
CC	       **************************************************
CC	SEQRES QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	ATOM   QSTVGNTG-FKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVL
CC	       ******** *****************************************
CC	SEQRES GIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFL
CC	ATOM   GIGDRHNDNIMITETGNLFHIDFGH-------------ERVPFVLTPDFL
CC	       *************************             ************
CC	SEQRES FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	ATOM   FVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQL
CC	       **************************************************
CC	SEQRES TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	ATOM   TSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVL
CC	       **************************************************
CC	SEQRES GIKQGEKHSAHHHHHH
CC	ATOM   ----------------
CC	                       
SQ	SEQUENCE	966 AA;      MW;         CN;
	MSEESQAFQR QLTALIGYDV TDVSNVHDDE LEFTRRGLVT PRMAEVASRD PKLYAMHPWV
	TSKPLPEYLW KKIANNCIFI VIHRSTTSQT IKVSPDDTPG AILQSFFTKM AKKKSLMDIP
	ESQSEQDFVL RVCGRDEYLV GETPIKNFQW VRHCLKNGEE IHVVLDTPPD PALDEVRKEE
	WPLVDDCTGV TGYHEQLTIH GKDHESVFTV SLWDCDRKFR VKIRGIDIPV LPRNTDLTVF
	VEANIQHGQQ VLCQRRTSPK PFTEEVLWNV WLEFSIKIKD LPKGALLNLQ IYCGKAPALS
	SKASAESPSS ESKGKVRLLY YVNLLLIDHR FLLRRGEYVL HMWQISGKGE DQGSFNADKL
	TSATNPDKEN SMSISILLDN YCHPIALPKH QPTPDPEGDR VRAEMPNQLR KQLEAIIATD
	PLNPLTAEDK ELLWHFRYES LKHPKAYPKL FSSVKWGQQE IVAKTYQLLA RREVWDQSAL
	DVGLTMQLLD CNFSDENVRA IAVQKLESLE DDDVLHYLLQ LVQAVKFEPY HDSALARFLL
	KRGLRNKRIG HFLFWFLRSE IAQSRHYQQR FAVILEAYLR GCGTAMLHDF TQQVQVIEML
	QKVTLDIKSL SAEKYDVSSQ VISQLKQKLE NLQNSQLPES FRVPYDPGLK AGALAIEKCK
	VMASKKKPLW LEFKCADPTA LSNETIGIIF KHGDDLRQDM LILQILRIME SIWETESLDL
	CLLPYGCIST GDKIGMIEIV KDATTIAKIQ QSTVGNTGAF KDEVLNHWLK EKSPTEEKFQ
	AAVERFVYSC AGYCVATFVL GIGDRHNDNI MITETGNLFH IDFGHILGNY KSFLGINKER
	VPFVLTPDFL FVMGTSGKKT SPHFQKFQDI CVKAYLALRH HTNLLIILFS MMLMTGMPQL
	TSKEDIEYIR DALTVGKNEE DAKKYFLDQI EVCRDKGWTV QFNWFLHLVL GIKQGEKHSA
	HHHHHH
//