ID	1E2PA	STANDARD;	PRT;	331	AA.
DT	CONVERTED FROM PDB (SEQRES) 1E2P
DE	THYMIDINE KINASE
OS	HERPES SIMPLEX VIRUS TYPE 1
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.500
CC	R-Factor	0.209
FT	#SUB	42	  87 	TYR	A	262	 307 	VAL	B	Protein	S	1
FT	#SUB	42	  87 	TYR	A	263	 308 	PHE	B	Protein	S	3
FT	#SUB	46	  91 	LEU	A	140	 185 	GLN	B	Protein	B	4
FT	#SUB	46	  91 	LEU	A	260	 305 	TYR	B	Protein	S	4
FT	#SUB	46	  91 	LEU	A	263	 308 	PHE	B	Protein	B	1
FT	#SUB	47	  92 	GLY	A	140	 185 	GLN	B	Protein	B	7
FT	#SUB	74	 119 	VAL	A	74	 119 	VAL	B	Protein	A	6
FT	#SUB	74	 119 	VAL	A	75	 120 	VAL	B	Protein	S	2
FT	#SUB	74	 119 	VAL	A	78	 123 	SER	B	Protein	B	2
FT	#SUB	75	 120 	VAL	A	74	 119 	VAL	B	Protein	A	3
FT	#SUB	77	 122 	THR	A	78	 123 	SER	B	Protein	S	2
FT	#SUB	77	 122 	THR	A	81	 126 	ILE	B	Protein	S	1
FT	#SUB	78	 123 	SER	A	74	 119 	VAL	B	Protein	S	3
FT	#SUB	78	 123 	SER	A	77	 122 	THR	B	Protein	S	3
FT	#SUB	81	 126 	ILE	A	77	 122 	THR	B	Protein	S	1
FT	#SUB	81	 126 	ILE	A	81	 126 	ILE	B	Protein	S	1
FT	#SUB	81	 126 	ILE	A	144	 189 	ALA	B	Protein	S	1
FT	#SUB	85	 130 	MET	A	143	 188 	LEU	B	Protein	S	2
FT	#SUB	85	 130 	MET	A	144	 189 	ALA	B	Protein	S	2
FT	#SUB	85	 130 	MET	A	262	 307 	VAL	B	Protein	S	1
FT	#SUB	85	 130 	MET	A	266	 311 	ALA	B	Protein	S	1
FT	#SUB	88	 133 	ALA	A	148	 193 	LEU	B	Protein	S	1
FT	#SUB	89	 134 	VAL	A	147	 192 	ALA	B	Protein	A	3
FT	#SUB	89	 134 	VAL	A	262	 307 	VAL	B	Protein	S	2
FT	#SUB	89	 134 	VAL	A	265	 310 	TRP	B	Protein	S	3
FT	#SUB	89	 134 	VAL	A	266	 311 	ALA	B	Protein	S	2
FT	#SUB	92	 137 	ALA	A	269	 314 	VAL	B	Protein	S	1
FT	#SUB	93	 138 	VAL	A	265	 310 	TRP	B	Protein	S	1
FT	#SUB	93	 138 	VAL	A	269	 314 	VAL	B	Protein	S	1
FT	#SUB	140	 185 	GLN	A	42	  87 	TYR	B	Protein	S	1
FT	#SUB	140	 185 	GLN	A	46	  91 	LEU	B	Protein	S	3
FT	#SUB	140	 185 	GLN	A	47	  92 	GLY	B	Protein	S	5
FT	#SUB	144	 189 	ALA	A	81	 126 	ILE	B	Protein	S	1
FT	#SUB	144	 189 	ALA	A	85	 130 	MET	B	Protein	A	2
FT	#SUB	145	 190 	PHE	A	81	 126 	ILE	B	Protein	S	1
FT	#SUB	148	 193 	LEU	A	88	 133 	ALA	B	Protein	S	1
FT	#SUB	148	 193 	LEU	A	148	 193 	LEU	B	Protein	S	1
FT	#SUB	260	 305 	TYR	A	46	  91 	LEU	B	Protein	S	4
FT	#SUB	260	 305 	TYR	A	326	 371 	GLU	B	Protein	A	11
FT	#SUB	261	 306 	ASN	A	322	 367 	THR	B	Protein	S	4
FT	#SUB	261	 306 	ASN	A	326	 371 	GLU	B	Protein	A	13
FT	#SUB	262	 307 	VAL	A	42	  87 	TYR	B	Protein	S	4
FT	#SUB	262	 307 	VAL	A	89	 134 	VAL	B	Protein	B	1
FT	#SUB	262	 307 	VAL	A	326	 371 	GLU	B	Protein	A	5
FT	#SUB	262	 307 	VAL	A	327	 372 	MET	B	Protein	S	2
FT	#SUB	263	 308 	PHE	A	42	  87 	TYR	B	Protein	S	3
FT	#SUB	263	 308 	PHE	A	46	  91 	LEU	B	Protein	S	1
FT	#SUB	263	 308 	PHE	A	85	 130 	MET	B	Protein	S	2
FT	#SUB	265	 310 	TRP	A	89	 134 	VAL	B	Protein	A	3
FT	#SUB	265	 310 	TRP	A	93	 138 	VAL	B	Protein	S	1
FT	#SUB	265	 310 	TRP	A	319	 364 	LEU	B	Protein	S	5
FT	#SUB	265	 310 	TRP	A	322	 367 	THR	B	Protein	S	4
FT	#SUB	265	 310 	TRP	A	323	 368 	PHE	B	Protein	S	2
FT	#SUB	266	 311 	ALA	A	89	 134 	VAL	B	Protein	B	2
FT	#SUB	269	 314 	VAL	A	92	 137 	ALA	B	Protein	S	1
FT	#SUB	272	 317 	LYS	A	96	 141 	PRO	B	Protein	S	1
FT	#SUB	319	 364 	LEU	A	265	 310 	TRP	B	Protein	A	5
FT	#SUB	322	 367 	THR	A	261	 306 	ASN	B	Protein	S	3
FT	#SUB	322	 367 	THR	A	265	 310 	TRP	B	Protein	S	1
FT	#SUB	323	 368 	PHE	A	265	 310 	TRP	B	Protein	B	2
FT	#SUB	326	 371 	GLU	A	260	 305 	TYR	B	Protein	S	8
FT	#SUB	326	 371 	GLU	A	261	 306 	ASN	B	Protein	S	12
FT	#SUB	326	 371 	GLU	A	262	 307 	VAL	B	Protein	S	2
FT	#SUB	327	 372 	MET	A	262	 307 	VAL	B	Protein	S	3
FT	#HET	13	  58 	HIS	A	1	400 	SO4	A	A	3
FT	#HET	13	  58 	HIS	A	2	500 	CCV	A	S	7
FT	#HET	14	  59 	GLY	A	1	400 	SO4	A	B	8
FT	#HET	15	  60 	MET	A	1	400 	SO4	A	B	2
FT	#HET	16	  61 	GLY	A	1	400 	SO4	A	B	4
FT	#HET	17	  62 	LYS	A	1	400 	SO4	A	A	10
FT	#HET	18	  63 	THR	A	1	400 	SO4	A	A	6
FT	#HET	38	  83 	GLU	A	2	500 	CCV	A	S	2
FT	#HET	43	  88 	TRP	A	2	500 	CCV	A	S	2
FT	#HET	55	 100 	ILE	A	2	500 	CCV	A	S	3
FT	#HET	56	 101 	TYR	A	2	500 	CCV	A	S	2
FT	#HET	80	 125 	GLN	A	2	500 	CCV	A	S	11
FT	#HET	83	 128 	MET	A	2	500 	CCV	A	S	9
FT	#HET	87	 132 	TYR	A	2	500 	CCV	A	S	1
FT	#HET	118	 163 	ARG	A	2	500 	CCV	A	S	5
FT	#HET	122	 167 	ALA	A	2	500 	CCV	A	B	1
FT	#HET	123	 168 	ALA	A	2	500 	CCV	A	A	2
FT	#HET	127	 172 	TYR	A	2	500 	CCV	A	S	23
FT	#HET	175	 220 	ARG	A	1	400 	SO4	A	S	3
FT	#HET	177	 222 	ARG	A	1	400 	SO4	A	S	8
FT	#HET	177	 222 	ARG	A	2	500 	CCV	A	S	5
FT	DISORDER	25	29
FT	DISORDER	105	108
FT	DISORDER	220	234
FT	DISORDER	330	331
CC	SEQUENCE	305 AA (ATOM);
CC	MPTLLRVYID GPHGMGKTTT TQLLRDDIVY VPEPMTYWRV LGASETIANI YTTQHRLDQG
CC	EISAGDAAVV MTSAQITMGM PYAVTDAVLA PHIGGEAGSP PALTLIFDRH PIAALLCYPA
CC	ARYLMGSMTP QAVLAFVALI PPTLPGTNIV LGALPEDRHI DRLAKRQRPG ERLDLAMLAA
CC	IRRVYGLLAN TVRYLQCGGS WREDWGQLSG PRPHIGDTLF TLFRAPELLA PNGDLYNVFA
CC	WALDVLAKRL RSMHVFILDY DQSPAGCRDA LLQLTSGMVQ THVTTPGSIP TICDLARTFA
CC	REMGE
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASE
CC	ATOM   MPTLLRVYIDGPHGMGKTTTTQLL-----RDDIVYVPEPMTYWRVLGASE
CC	       ************************     *********************
CC	SEQRES TIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGG
CC	ATOM   TIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGG
CC	       **************************************************
CC	SEQRES EAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIP
CC	ATOM   EAGS----PPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIP
CC	       ****    ******************************************
CC	SEQRES PTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANT
CC	ATOM   PTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANT
CC	       **************************************************
CC	SEQRES VRYLQCGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAP
CC	ATOM   VRYLQCGGSWREDWGQLSG---------------PRPHIGDTLFTLFRAP
CC	       *******************               ****************
CC	SEQRES ELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTS
CC	ATOM   ELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTS
CC	       **************************************************
CC	SEQRES GMVQTHVTTPGSIPTICDLARTFAREMGEAN
CC	ATOM   GMVQTHVTTPGSIPTICDLARTFAREMGE--
CC	       *****************************  
SQ	SEQUENCE	331 AA;      MW;         CN;
	MPTLLRVYID GPHGMGKTTT TQLLVALGSR DDIVYVPEPM TYWRVLGASE TIANIYTTQH
	RLDQGEISAG DAAVVMTSAQ ITMGMPYAVT DAVLAPHIGG EAGSSHAPPP ALTLIFDRHP
	IAALLCYPAA RYLMGSMTPQ AVLAFVALIP PTLPGTNIVL GALPEDRHID RLAKRQRPGE
	RLDLAMLAAI RRVYGLLANT VRYLQCGGSW REDWGQLSGT AVPPQGAEPQ SNAGPRPHIG
	DTLFTLFRAP ELLAPNGDLY NVFAWALDVL AKRLRSMHVF ILDYDQSPAG CRDALLQLTS
	GMVQTHVTTP GSIPTICDLA RTFAREMGEA N
//
ID	1E2PB	STANDARD;	PRT;	331	AA.
DT	CONVERTED FROM PDB (SEQRES) 1E2P
DE	THYMIDINE KINASE
OS	HERPES SIMPLEX VIRUS TYPE 1
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	2.500
CC	R-Factor	0.209
FT	#SUB	42	  87 	TYR	B	140	 185 	GLN	A	Protein	S	1
FT	#SUB	42	  87 	TYR	B	262	 307 	VAL	A	Protein	S	4
FT	#SUB	42	  87 	TYR	B	263	 308 	PHE	A	Protein	S	3
FT	#SUB	46	  91 	LEU	B	140	 185 	GLN	A	Protein	B	3
FT	#SUB	46	  91 	LEU	B	260	 305 	TYR	A	Protein	S	4
FT	#SUB	46	  91 	LEU	B	263	 308 	PHE	A	Protein	B	1
FT	#SUB	47	  92 	GLY	B	140	 185 	GLN	A	Protein	B	5
FT	#SUB	74	 119 	VAL	B	74	 119 	VAL	A	Protein	A	6
FT	#SUB	74	 119 	VAL	B	75	 120 	VAL	A	Protein	S	3
FT	#SUB	74	 119 	VAL	B	78	 123 	SER	A	Protein	A	3
FT	#SUB	75	 120 	VAL	B	74	 119 	VAL	A	Protein	B	2
FT	#SUB	77	 122 	THR	B	78	 123 	SER	A	Protein	S	3
FT	#SUB	77	 122 	THR	B	81	 126 	ILE	A	Protein	S	1
FT	#SUB	78	 123 	SER	B	74	 119 	VAL	A	Protein	S	2
FT	#SUB	78	 123 	SER	B	77	 122 	THR	A	Protein	S	2
FT	#SUB	81	 126 	ILE	B	77	 122 	THR	A	Protein	S	1
FT	#SUB	81	 126 	ILE	B	81	 126 	ILE	A	Protein	S	1
FT	#SUB	81	 126 	ILE	B	144	 189 	ALA	A	Protein	S	1
FT	#SUB	81	 126 	ILE	B	145	 190 	PHE	A	Protein	S	1
FT	#SUB	85	 130 	MET	B	144	 189 	ALA	A	Protein	S	2
FT	#SUB	85	 130 	MET	B	263	 308 	PHE	A	Protein	S	2
FT	#SUB	88	 133 	ALA	B	148	 193 	LEU	A	Protein	S	1
FT	#SUB	89	 134 	VAL	B	262	 307 	VAL	A	Protein	S	1
FT	#SUB	89	 134 	VAL	B	265	 310 	TRP	A	Protein	S	3
FT	#SUB	89	 134 	VAL	B	266	 311 	ALA	A	Protein	S	2
FT	#SUB	92	 137 	ALA	B	269	 314 	VAL	A	Protein	S	1
FT	#SUB	93	 138 	VAL	B	265	 310 	TRP	A	Protein	S	1
FT	#SUB	96	 141 	PRO	B	272	 317 	LYS	A	Protein	S	1
FT	#SUB	140	 185 	GLN	B	46	  91 	LEU	A	Protein	S	4
FT	#SUB	140	 185 	GLN	B	47	  92 	GLY	A	Protein	S	7
FT	#SUB	143	 188 	LEU	B	85	 130 	MET	A	Protein	B	2
FT	#SUB	144	 189 	ALA	B	81	 126 	ILE	A	Protein	S	1
FT	#SUB	144	 189 	ALA	B	85	 130 	MET	A	Protein	A	2
FT	#SUB	147	 192 	ALA	B	89	 134 	VAL	A	Protein	S	3
FT	#SUB	148	 193 	LEU	B	88	 133 	ALA	A	Protein	S	1
FT	#SUB	148	 193 	LEU	B	148	 193 	LEU	A	Protein	B	1
FT	#SUB	260	 305 	TYR	B	46	  91 	LEU	A	Protein	S	4
FT	#SUB	260	 305 	TYR	B	326	 371 	GLU	A	Protein	A	8
FT	#SUB	261	 306 	ASN	B	322	 367 	THR	A	Protein	S	3
FT	#SUB	261	 306 	ASN	B	326	 371 	GLU	A	Protein	A	12
FT	#SUB	262	 307 	VAL	B	42	  87 	TYR	A	Protein	S	1
FT	#SUB	262	 307 	VAL	B	85	 130 	MET	A	Protein	S	1
FT	#SUB	262	 307 	VAL	B	89	 134 	VAL	A	Protein	A	2
FT	#SUB	262	 307 	VAL	B	326	 371 	GLU	A	Protein	A	2
FT	#SUB	262	 307 	VAL	B	327	 372 	MET	A	Protein	S	3
FT	#SUB	263	 308 	PHE	B	42	  87 	TYR	A	Protein	S	3
FT	#SUB	263	 308 	PHE	B	46	  91 	LEU	A	Protein	S	1
FT	#SUB	265	 310 	TRP	B	89	 134 	VAL	A	Protein	A	3
FT	#SUB	265	 310 	TRP	B	93	 138 	VAL	A	Protein	B	1
FT	#SUB	265	 310 	TRP	B	319	 364 	LEU	A	Protein	S	5
FT	#SUB	265	 310 	TRP	B	322	 367 	THR	A	Protein	S	1
FT	#SUB	265	 310 	TRP	B	323	 368 	PHE	A	Protein	S	2
FT	#SUB	266	 311 	ALA	B	85	 130 	MET	A	Protein	S	1
FT	#SUB	266	 311 	ALA	B	89	 134 	VAL	A	Protein	B	2
FT	#SUB	269	 314 	VAL	B	92	 137 	ALA	A	Protein	S	1
FT	#SUB	269	 314 	VAL	B	93	 138 	VAL	A	Protein	S	1
FT	#SUB	319	 364 	LEU	B	265	 310 	TRP	A	Protein	A	5
FT	#SUB	322	 367 	THR	B	261	 306 	ASN	A	Protein	S	4
FT	#SUB	322	 367 	THR	B	265	 310 	TRP	A	Protein	S	4
FT	#SUB	323	 368 	PHE	B	265	 310 	TRP	A	Protein	B	2
FT	#SUB	326	 371 	GLU	B	260	 305 	TYR	A	Protein	S	11
FT	#SUB	326	 371 	GLU	B	261	 306 	ASN	A	Protein	S	13
FT	#SUB	326	 371 	GLU	B	262	 307 	VAL	A	Protein	S	5
FT	#SUB	327	 372 	MET	B	262	 307 	VAL	A	Protein	S	2
FT	#HET	13	  58 	HIS	B	3	400 	SO4	B	A	3
FT	#HET	13	  58 	HIS	B	4	500 	CCV	B	S	1
FT	#HET	14	  59 	GLY	B	3	400 	SO4	B	B	8
FT	#HET	15	  60 	MET	B	3	400 	SO4	B	B	3
FT	#HET	16	  61 	GLY	B	3	400 	SO4	B	B	6
FT	#HET	17	  62 	LYS	B	3	400 	SO4	B	A	14
FT	#HET	18	  63 	THR	B	3	400 	SO4	B	A	4
FT	#HET	38	  83 	GLU	B	4	500 	CCV	B	S	2
FT	#HET	55	 100 	ILE	B	4	500 	CCV	B	S	1
FT	#HET	56	 101 	TYR	B	4	500 	CCV	B	S	1
FT	#HET	80	 125 	GLN	B	4	500 	CCV	B	S	10
FT	#HET	83	 128 	MET	B	4	500 	CCV	B	S	7
FT	#HET	87	 132 	TYR	B	4	500 	CCV	B	S	1
FT	#HET	118	 163 	ARG	B	4	500 	CCV	B	S	8
FT	#HET	123	 168 	ALA	B	4	500 	CCV	B	A	2
FT	#HET	127	 172 	TYR	B	4	500 	CCV	B	S	32
FT	DISORDER	105	108
FT	DISORDER	175	180
FT	DISORDER	220	228
FT	DISORDER	330	331
CC	SEQUENCE	310 AA (ATOM);
CC	MPTLLRVYID GPHGMGKTTT TQLLVALGSR DDIVYVPEPM TYWRVLGASE TIANIYTTQH
CC	RLDQGEISAG DAAVVMTSAQ ITMGMPYAVT DAVLAPHIGG EAGSPPALTL IFDRHPIAAL
CC	LCYPAARYLM GSMTPQAVLA FVALIPPTLP GTNIVLGALP EDRHIDRLAK RLDLAMLAAI
CC	RRVYGLLANT VRYLQCGGSW REDWGQLSGP QSNAGPRPHI GDTLFTLFRA PELLAPNGDL
CC	YNVFAWALDV LAKRLRSMHV FILDYDQSPA GCRDALLQLT SGMVQTHVTT PGSIPTICDL
CC	ARTFAREMGE
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASE
CC	ATOM   MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASE
CC	       **************************************************
CC	SEQRES TIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGG
CC	ATOM   TIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGG
CC	       **************************************************
CC	SEQRES EAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIP
CC	ATOM   EAGS----PPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIP
CC	       ****    ******************************************
CC	SEQRES PTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANT
CC	ATOM   PTLPGTNIVLGALPEDRHIDRLAK------RLDLAMLAAIRRVYGLLANT
CC	       ************************      ********************
CC	SEQRES VRYLQCGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAP
CC	ATOM   VRYLQCGGSWREDWGQLSG---------PQSNAGPRPHIGDTLFTLFRAP
CC	       *******************         **********************
CC	SEQRES ELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTS
CC	ATOM   ELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTS
CC	       **************************************************
CC	SEQRES GMVQTHVTTPGSIPTICDLARTFAREMGEAN
CC	ATOM   GMVQTHVTTPGSIPTICDLARTFAREMGE--
CC	       *****************************  
SQ	SEQUENCE	331 AA;      MW;         CN;
	MPTLLRVYID GPHGMGKTTT TQLLVALGSR DDIVYVPEPM TYWRVLGASE TIANIYTTQH
	RLDQGEISAG DAAVVMTSAQ ITMGMPYAVT DAVLAPHIGG EAGSSHAPPP ALTLIFDRHP
	IAALLCYPAA RYLMGSMTPQ AVLAFVALIP PTLPGTNIVL GALPEDRHID RLAKRQRPGE
	RLDLAMLAAI RRVYGLLANT VRYLQCGGSW REDWGQLSGT AVPPQGAEPQ SNAGPRPHIG
	DTLFTLFRAP ELLAPNGDLY NVFAWALDVL AKRLRSMHVF ILDYDQSPAG CRDALLQLTS
	GMVQTHVTTP GSIPTICDLA RTFAREMGEA N
//