ID	1A4IA	STANDARD;	PRT;	301	AA.
DT	CONVERTED FROM PDB (SEQRES) 1A4I
DE	METHYLENETETRAHYDROFOLATE DEHYDROGENASE / METHENYLTETRAHYDROFOLATE CYCLOHYD
DE	ROLASE
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.500
CC	R-Factor	0.199
FT	#SUB	112	 112 	GLU	A	139	 139 	ASP	B	Protein	S	5
FT	#SUB	129	 129 	SER	A	129	 129 	SER	B	Protein	B	1
FT	#SUB	129	 129 	SER	A	130	 130 	ILE	B	Protein	S	1
FT	#SUB	129	 129 	SER	A	133	 133 	GLY	B	Protein	B	1
FT	#SUB	129	 129 	SER	A	134	 134 	ARG	B	Protein	S	1
FT	#SUB	130	 130 	ILE	A	130	 130 	ILE	B	Protein	S	3
FT	#SUB	132	 132 	ALA	A	137	 137 	ARG	B	Protein	A	2
FT	#SUB	133	 133 	GLY	A	129	 129 	SER	B	Protein	B	1
FT	#SUB	133	 133 	GLY	A	133	 133 	GLY	B	Protein	B	4
FT	#SUB	135	 135 	LEU	A	137	 137 	ARG	B	Protein	S	1
FT	#SUB	136	 136 	ALA	A	136	 136 	ALA	B	Protein	S	1
FT	#SUB	137	 137 	ARG	A	132	 132 	ALA	B	Protein	S	6
FT	#SUB	137	 137 	ARG	A	135	 135 	LEU	B	Protein	S	1
FT	#SUB	137	 137 	ARG	A	175	 175 	LYS	B	Protein	A	3
FT	#SUB	137	 137 	ARG	A	179	 179 	ALA	B	Protein	S	4
FT	#SUB	137	 137 	ARG	A	180	 180 	PRO	B	Protein	S	6
FT	#SUB	137	 137 	ARG	A	183	 183 	ASP	B	Protein	S	4
FT	#SUB	139	 139 	ASP	A	112	 112 	GLU	B	Protein	S	1
FT	#SUB	139	 139 	ASP	A	175	 175 	LYS	B	Protein	S	6
FT	#SUB	165	 165 	GLY	A	198	 198 	LYS	B	Protein	B	1
FT	#SUB	167	 167 	HIS	A	205	 205 	GLU	B	Protein	S	7
FT	#SUB	173	 173 	ARG	A	186	 186 	LEU	B	Protein	S	3
FT	#SUB	173	 173 	ARG	A	187	 187 	TRP	B	Protein	A	9
FT	#SUB	173	 173 	ARG	A	189	 189 	ASN	B	Protein	S	4
FT	#SUB	175	 175 	LYS	A	137	 137 	ARG	B	Protein	S	3
FT	#SUB	179	 179 	ALA	A	137	 137 	ARG	B	Protein	A	6
FT	#SUB	180	 180 	PRO	A	137	 137 	ARG	B	Protein	A	7
FT	#SUB	182	 182 	HIS	A	182	 182 	HIS	B	Protein	S	8
FT	#SUB	182	 182 	HIS	A	194	 194 	THR	B	Protein	S	1
FT	#SUB	183	 183 	ASP	A	137	 137 	ARG	B	Protein	S	5
FT	#SUB	186	 186 	LEU	A	173	 173 	ARG	B	Protein	B	2
FT	#SUB	186	 186 	LEU	A	194	 194 	THR	B	Protein	S	2
FT	#SUB	186	 186 	LEU	A	196	 196 	HIS	B	Protein	S	1
FT	#SUB	187	 187 	TRP	A	173	 173 	ARG	B	Protein	S	9
FT	#SUB	189	 189 	ASN	A	173	 173 	ARG	B	Protein	S	4
FT	#SUB	189	 189 	ASN	A	196	 196 	HIS	B	Protein	B	5
FT	#SUB	189	 189 	ASN	A	198	 198 	LYS	B	Protein	S	2
FT	#SUB	190	 190 	ALA	A	196	 196 	HIS	B	Protein	B	4
FT	#SUB	191	 191 	THR	A	193	 193 	THR	B	Protein	S	1
FT	#SUB	191	 191 	THR	A	194	 194 	THR	B	Protein	A	3
FT	#SUB	191	 191 	THR	A	195	 195 	CYS	B	Protein	S	1
FT	#SUB	191	 191 	THR	A	199	 199 	THR	B	Protein	S	6
FT	#SUB	191	 191 	THR	A	205	 205 	GLU	B	Protein	S	1
FT	#SUB	192	 192 	VAL	A	192	 192 	VAL	B	Protein	B	1
FT	#SUB	192	 192 	VAL	A	193	 193 	THR	B	Protein	B	3
FT	#SUB	192	 192 	VAL	A	194	 194 	THR	B	Protein	B	5
FT	#SUB	193	 193 	THR	A	167	 167 	HIS	B	Protein	S	1
FT	#SUB	193	 193 	THR	A	191	 191 	THR	B	Protein	S	1
FT	#SUB	193	 193 	THR	A	192	 192 	VAL	B	Protein	A	3
FT	#SUB	193	 193 	THR	A	193	 193 	THR	B	Protein	A	6
FT	#SUB	194	 194 	THR	A	186	 186 	LEU	B	Protein	S	1
FT	#SUB	194	 194 	THR	A	191	 191 	THR	B	Protein	B	3
FT	#SUB	194	 194 	THR	A	192	 192 	VAL	B	Protein	B	3
FT	#SUB	196	 196 	HIS	A	186	 186 	LEU	B	Protein	S	1
FT	#SUB	196	 196 	HIS	A	189	 189 	ASN	B	Protein	S	5
FT	#SUB	196	 196 	HIS	A	190	 190 	ALA	B	Protein	S	4
FT	#SUB	198	 198 	LYS	A	165	 165 	GLY	B	Protein	B	2
FT	#SUB	198	 198 	LYS	A	189	 189 	ASN	B	Protein	S	3
FT	#SUB	199	 199 	THR	A	191	 191 	THR	B	Protein	A	5
FT	#SUB	205	 205 	GLU	A	167	 167 	HIS	B	Protein	S	7
FT	#SUB	205	 205 	GLU	A	191	 191 	THR	B	Protein	S	2
FT	#SUB	208	 208 	LYS	A	167	 167 	HIS	B	Protein	S	2
FT	#HET	148	 148 	THR	A	1	302 	NDP	A	S	3
FT	#HET	171	 171 	VAL	A	1	302 	NDP	A	S	2
FT	#HET	172	 172 	GLY	A	1	302 	NDP	A	B	4
FT	#HET	173	 173 	ARG	A	1	302 	NDP	A	A	14
FT	#HET	174	 174 	SER	A	1	302 	NDP	A	A	7
FT	#HET	177	 177 	VAL	A	1	302 	NDP	A	S	4
FT	#HET	196	 196 	HIS	A	1	302 	NDP	A	A	10
FT	#HET	197	 197 	SER	A	1	302 	NDP	A	A	16
FT	#HET	202	 202 	LEU	A	1	302 	NDP	A	S	1
FT	#HET	215	 215 	ALA	A	1	302 	NDP	A	B	6
FT	#HET	216	 216 	THR	A	1	302 	NDP	A	A	15
FT	#HET	217	 217 	GLY	A	1	302 	NDP	A	B	7
FT	#HET	218	 218 	GLN	A	1	302 	NDP	A	S	4
FT	#HET	221	 221 	MET	A	1	302 	NDP	A	S	3
FT	#HET	236	 236 	CYS	A	1	302 	NDP	A	A	7
FT	#HET	237	 237 	GLY	A	1	302 	NDP	A	B	2
FT	#HET	238	 238 	ILE	A	1	302 	NDP	A	A	6
FT	#HET	255	 255 	ASP	A	1	302 	NDP	A	S	1
FT	#HET	276	 276 	GLY	A	1	302 	NDP	A	B	1
FT	#HET	279	 279 	THR	A	1	302 	NDP	A	S	1
FT	DISORDER	1	1
FT	DISORDER	241	250
FT	DISORDER	297	301
CC	SEQUENCE	285 AA (ATOM);
CC	APAEILNGKE ISAQIRARLK NQVTQLKEQV PGFTPRLAIL QVGNRDDSNL YINVKLKAAE
CC	EIGIKATHIK LPRTTTESEV MKYITSLNED STVHGFLVQL PLDSENSINT EEVINAIAPE
CC	KDVDGLTSIN AGRLARGDLN DCFIPCTPKG CLELIKETGV PIAGRHAVVV GRSKIVGAPM
CC	HDLLLWNNAT VTTCHSKTAH LDEEVNKGDI LVVATGQPEM VKGEWIKPGA IVIDCGINYK
CC	VVGDVAYDEA KERASFITPV PGGVGPMTVA MLMQSTVESA KRFLE
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSN
CC	ATOM   -APAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSN
CC	        *************************************************
CC	SEQRES LYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQ
CC	ATOM   LYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQ
CC	       **************************************************
CC	SEQRES LPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPK
CC	ATOM   LPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPK
CC	       **************************************************
CC	SEQRES GCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTA
CC	ATOM   GCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTA
CC	       **************************************************
CC	SEQRES HLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGR
CC	ATOM   HLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY----------
CC	       ****************************************          
CC	SEQRES KVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
CC	ATOM   KVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLE----
CC	       **********************************************    
CC	SEQRES G
CC	ATOM   -
CC	        
SQ	SEQUENCE	301 AA;      MW;         CN;
	MAPAEILNGK EISAQIRARL KNQVTQLKEQ VPGFTPRLAI LQVGNRDDSN LYINVKLKAA
	EEIGIKATHI KLPRTTTESE VMKYITSLNE DSTVHGFLVQ LPLDSENSIN TEEVINAIAP
	EKDVDGLTSI NAGRLARGDL NDCFIPCTPK GCLELIKETG VPIAGRHAVV VGRSKIVGAP
	MHDLLLWNNA TVTTCHSKTA HLDEEVNKGD ILVVATGQPE MVKGEWIKPG AIVIDCGINY
	VPDDKKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLEKFKP
	G
//
ID	1A4IB	STANDARD;	PRT;	301	AA.
DT	CONVERTED FROM PDB (SEQRES) 1A4I
DE	METHYLENETETRAHYDROFOLATE DEHYDROGENASE / METHENYLTETRAHYDROFOLATE CYCLOHYD
DE	ROLASE
OS	Homo sapiens
CC	EXPDTA	X-RAY DIFFRACTION
CC	RESOLU	1.500
CC	R-Factor	0.199
FT	#SUB	112	 112 	GLU	B	139	 139 	ASP	A	Protein	S	1
FT	#SUB	129	 129 	SER	B	129	 129 	SER	A	Protein	B	1
FT	#SUB	129	 129 	SER	B	133	 133 	GLY	A	Protein	B	1
FT	#SUB	130	 130 	ILE	B	129	 129 	SER	A	Protein	B	1
FT	#SUB	130	 130 	ILE	B	130	 130 	ILE	A	Protein	S	3
FT	#SUB	132	 132 	ALA	B	137	 137 	ARG	A	Protein	A	6
FT	#SUB	133	 133 	GLY	B	129	 129 	SER	A	Protein	B	1
FT	#SUB	133	 133 	GLY	B	133	 133 	GLY	A	Protein	B	4
FT	#SUB	134	 134 	ARG	B	129	 129 	SER	A	Protein	S	1
FT	#SUB	135	 135 	LEU	B	137	 137 	ARG	A	Protein	S	1
FT	#SUB	136	 136 	ALA	B	136	 136 	ALA	A	Protein	S	1
FT	#SUB	137	 137 	ARG	B	132	 132 	ALA	A	Protein	S	2
FT	#SUB	137	 137 	ARG	B	135	 135 	LEU	A	Protein	S	1
FT	#SUB	137	 137 	ARG	B	175	 175 	LYS	A	Protein	A	3
FT	#SUB	137	 137 	ARG	B	179	 179 	ALA	A	Protein	S	6
FT	#SUB	137	 137 	ARG	B	180	 180 	PRO	A	Protein	S	7
FT	#SUB	137	 137 	ARG	B	183	 183 	ASP	A	Protein	S	5
FT	#SUB	139	 139 	ASP	B	112	 112 	GLU	A	Protein	S	5
FT	#SUB	165	 165 	GLY	B	198	 198 	LYS	A	Protein	B	2
FT	#SUB	167	 167 	HIS	B	193	 193 	THR	A	Protein	S	1
FT	#SUB	167	 167 	HIS	B	205	 205 	GLU	A	Protein	S	7
FT	#SUB	167	 167 	HIS	B	208	 208 	LYS	A	Protein	S	2
FT	#SUB	173	 173 	ARG	B	186	 186 	LEU	A	Protein	S	2
FT	#SUB	173	 173 	ARG	B	187	 187 	TRP	A	Protein	A	9
FT	#SUB	173	 173 	ARG	B	189	 189 	ASN	A	Protein	S	4
FT	#SUB	175	 175 	LYS	B	137	 137 	ARG	A	Protein	S	3
FT	#SUB	175	 175 	LYS	B	139	 139 	ASP	A	Protein	S	6
FT	#SUB	179	 179 	ALA	B	137	 137 	ARG	A	Protein	A	4
FT	#SUB	180	 180 	PRO	B	137	 137 	ARG	A	Protein	A	6
FT	#SUB	182	 182 	HIS	B	182	 182 	HIS	A	Protein	S	8
FT	#SUB	183	 183 	ASP	B	137	 137 	ARG	A	Protein	S	4
FT	#SUB	186	 186 	LEU	B	173	 173 	ARG	A	Protein	A	3
FT	#SUB	186	 186 	LEU	B	194	 194 	THR	A	Protein	S	1
FT	#SUB	186	 186 	LEU	B	196	 196 	HIS	A	Protein	S	1
FT	#SUB	187	 187 	TRP	B	173	 173 	ARG	A	Protein	S	9
FT	#SUB	189	 189 	ASN	B	173	 173 	ARG	A	Protein	S	4
FT	#SUB	189	 189 	ASN	B	196	 196 	HIS	A	Protein	B	5
FT	#SUB	189	 189 	ASN	B	198	 198 	LYS	A	Protein	S	3
FT	#SUB	190	 190 	ALA	B	196	 196 	HIS	A	Protein	B	4
FT	#SUB	191	 191 	THR	B	193	 193 	THR	A	Protein	S	1
FT	#SUB	191	 191 	THR	B	194	 194 	THR	A	Protein	A	3
FT	#SUB	191	 191 	THR	B	199	 199 	THR	A	Protein	S	5
FT	#SUB	191	 191 	THR	B	205	 205 	GLU	A	Protein	S	2
FT	#SUB	192	 192 	VAL	B	192	 192 	VAL	A	Protein	B	1
FT	#SUB	192	 192 	VAL	B	193	 193 	THR	A	Protein	B	3
FT	#SUB	192	 192 	VAL	B	194	 194 	THR	A	Protein	B	3
FT	#SUB	193	 193 	THR	B	191	 191 	THR	A	Protein	S	1
FT	#SUB	193	 193 	THR	B	192	 192 	VAL	A	Protein	A	3
FT	#SUB	193	 193 	THR	B	193	 193 	THR	A	Protein	S	6
FT	#SUB	194	 194 	THR	B	182	 182 	HIS	A	Protein	S	1
FT	#SUB	194	 194 	THR	B	186	 186 	LEU	A	Protein	S	2
FT	#SUB	194	 194 	THR	B	191	 191 	THR	A	Protein	B	3
FT	#SUB	194	 194 	THR	B	192	 192 	VAL	A	Protein	B	5
FT	#SUB	195	 195 	CYS	B	191	 191 	THR	A	Protein	S	1
FT	#SUB	196	 196 	HIS	B	186	 186 	LEU	A	Protein	S	1
FT	#SUB	196	 196 	HIS	B	189	 189 	ASN	A	Protein	S	5
FT	#SUB	196	 196 	HIS	B	190	 190 	ALA	A	Protein	S	4
FT	#SUB	198	 198 	LYS	B	165	 165 	GLY	A	Protein	B	1
FT	#SUB	198	 198 	LYS	B	189	 189 	ASN	A	Protein	S	2
FT	#SUB	199	 199 	THR	B	191	 191 	THR	A	Protein	A	6
FT	#SUB	205	 205 	GLU	B	167	 167 	HIS	A	Protein	S	7
FT	#SUB	205	 205 	GLU	B	191	 191 	THR	A	Protein	S	1
FT	#HET	148	 148 	THR	B	2	302 	NDP	B	S	3
FT	#HET	171	 171 	VAL	B	2	302 	NDP	B	S	2
FT	#HET	172	 172 	GLY	B	2	302 	NDP	B	B	5
FT	#HET	173	 173 	ARG	B	2	302 	NDP	B	A	14
FT	#HET	174	 174 	SER	B	2	302 	NDP	B	A	7
FT	#HET	177	 177 	VAL	B	2	302 	NDP	B	S	4
FT	#HET	196	 196 	HIS	B	2	302 	NDP	B	A	9
FT	#HET	197	 197 	SER	B	2	302 	NDP	B	A	18
FT	#HET	202	 202 	LEU	B	2	302 	NDP	B	S	2
FT	#HET	215	 215 	ALA	B	2	302 	NDP	B	B	6
FT	#HET	216	 216 	THR	B	2	302 	NDP	B	A	14
FT	#HET	217	 217 	GLY	B	2	302 	NDP	B	B	6
FT	#HET	218	 218 	GLN	B	2	302 	NDP	B	S	6
FT	#HET	221	 221 	MET	B	2	302 	NDP	B	S	5
FT	#HET	236	 236 	CYS	B	2	302 	NDP	B	A	7
FT	#HET	237	 237 	GLY	B	2	302 	NDP	B	B	2
FT	#HET	238	 238 	ILE	B	2	302 	NDP	B	A	11
FT	#HET	255	 255 	ASP	B	2	302 	NDP	B	S	1
FT	#HET	276	 276 	GLY	B	2	302 	NDP	B	B	1
FT	#HET	279	 279 	THR	B	2	302 	NDP	B	S	2
FT	DISORDER	1	1
FT	DISORDER	297	301
CC	SEQUENCE	295 AA (ATOM);
CC	APAEILNGKE ISAQIRARLK NQVTQLKEQV PGFTPRLAIL QVGNRDDSNL YINVKLKAAE
CC	EIGIKATHIK LPRTTTESEV MKYITSLNED STVHGFLVQL PLDSENSINT EEVINAIAPE
CC	KDVDGLTSIN AGRLARGDLN DCFIPCTPKG CLELIKETGV PIAGRHAVVV GRSKIVGAPM
CC	HDLLLWNNAT VTTCHSKTAH LDEEVNKGDI LVVATGQPEM VKGEWIKPGA IVIDCGINYV
CC	PDDKKPNGRK VVGDVAYDEA KERASFITPV PGGVGPMTVA MLMQSTVESA KRFLE
CC	!----
CC	ALIGNMENT OF SEQRES AND ATOMRES
CC	SEQRES MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSN
CC	ATOM   -APAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSN
CC	        *************************************************
CC	SEQRES LYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQ
CC	ATOM   LYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQ
CC	       **************************************************
CC	SEQRES LPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPK
CC	ATOM   LPLDSENSINTEEVINAIAPEKDVDGLTSINAGRLARGDLNDCFIPCTPK
CC	       **************************************************
CC	SEQRES GCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTA
CC	ATOM   GCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTA
CC	       **************************************************
CC	SEQRES HLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGR
CC	ATOM   HLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYVPDDKKPNGR
CC	       **************************************************
CC	SEQRES KVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
CC	ATOM   KVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLE----
CC	       **********************************************    
CC	SEQRES G
CC	ATOM   -
CC	        
SQ	SEQUENCE	301 AA;      MW;         CN;
	MAPAEILNGK EISAQIRARL KNQVTQLKEQ VPGFTPRLAI LQVGNRDDSN LYINVKLKAA
	EEIGIKATHI KLPRTTTESE VMKYITSLNE DSTVHGFLVQ LPLDSENSIN TEEVINAIAP
	EKDVDGLTSI NAGRLARGDL NDCFIPCTPK GCLELIKETG VPIAGRHAVV VGRSKIVGAP
	MHDLLLWNNA TVTTCHSKTA HLDEEVNKGD ILVVATGQPE MVKGEWIKPG AIVIDCGINY
	VPDDKKPNGR KVVGDVAYDE AKERASFITP VPGGVGPMTV AMLMQSTVES AKRFLEKFKP
	G
//