data_H7T # _chem_comp.id H7T _chem_comp.name "2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone" _chem_comp.type NON-POLYMER _chem_comp.pdbx_type HETAIN _chem_comp.formula "C42 H58 N8 O4" _chem_comp.mon_nstd_parent_comp_id ? _chem_comp.pdbx_synonyms ? _chem_comp.pdbx_formal_charge 0 _chem_comp.pdbx_initial_date 2018-11-20 _chem_comp.pdbx_modified_date 2018-11-30 _chem_comp.pdbx_ambiguous_flag N _chem_comp.pdbx_release_status REL _chem_comp.pdbx_replaced_by ? _chem_comp.pdbx_replaces ? _chem_comp.formula_weight 738.961 _chem_comp.one_letter_code ? _chem_comp.three_letter_code H7T _chem_comp.pdbx_model_coordinates_details ? _chem_comp.pdbx_model_coordinates_missing_flag N _chem_comp.pdbx_ideal_coordinates_details Corina _chem_comp.pdbx_ideal_coordinates_missing_flag N _chem_comp.pdbx_model_coordinates_db_code 6I8B _chem_comp.pdbx_subcomponent_list ? _chem_comp.pdbx_processing_site EBI # loop_ _chem_comp_atom.comp_id _chem_comp_atom.atom_id _chem_comp_atom.alt_atom_id _chem_comp_atom.type_symbol _chem_comp_atom.charge _chem_comp_atom.pdbx_align _chem_comp_atom.pdbx_aromatic_flag _chem_comp_atom.pdbx_leaving_atom_flag _chem_comp_atom.pdbx_stereo_config _chem_comp_atom.model_Cartn_x _chem_comp_atom.model_Cartn_y _chem_comp_atom.model_Cartn_z _chem_comp_atom.pdbx_model_Cartn_x_ideal _chem_comp_atom.pdbx_model_Cartn_y_ideal _chem_comp_atom.pdbx_model_Cartn_z_ideal _chem_comp_atom.pdbx_component_atom_id _chem_comp_atom.pdbx_component_comp_id _chem_comp_atom.pdbx_ordinal H7T N1 N1 N 0 1 N N N 22.273 21.680 30.554 9.201 -2.531 -3.026 N1 H7T 1 H7T N3 N2 N 0 1 Y N N 12.399 14.802 39.836 -6.231 1.810 -0.584 N3 H7T 2 H7T C4 C1 C 0 1 Y N N 20.985 21.358 30.978 9.285 -1.980 -1.778 C4 H7T 3 H7T C5 C2 C 0 1 Y N N 19.943 22.244 31.215 8.600 -0.906 -1.197 C5 H7T 4 H7T C6 C3 C 0 1 Y N N 18.733 21.736 31.651 8.871 -0.537 0.106 C6 H7T 5 H7T C7 C4 C 0 1 N N N 17.875 23.901 32.192 7.237 1.172 -0.151 C7 H7T 6 H7T C8 C5 C 0 1 N N N 16.629 24.467 32.814 6.593 2.310 0.643 C8 H7T 7 H7T C10 C6 C 0 1 N N N 14.745 22.251 32.958 4.069 3.585 1.605 C10 H7T 8 H7T C13 C7 C 0 1 Y N N 11.959 19.698 33.676 0.405 2.860 0.636 C13 H7T 9 H7T C15 C8 C 0 1 N N N 11.999 17.832 36.806 -1.891 2.971 -0.787 C15 H7T 10 H7T C17 C9 C 0 1 Y N N 11.371 15.988 38.372 -4.257 2.392 -1.254 C17 H7T 11 H7T C20 C10 C 0 1 N N N 13.237 14.395 42.114 -8.415 0.848 -1.022 C20 H7T 12 H7T C21 C11 C 0 1 N N N 14.018 14.010 44.405 -10.449 1.508 0.169 C21 H7T 13 H7T C22 C12 C 0 1 N N N 15.349 14.509 44.934 -11.224 0.568 1.098 C22 H7T 14 H7T C24 C13 C 0 1 N N N 17.830 14.040 45.121 -12.935 -1.250 1.187 C24 H7T 15 H7T C26 C14 C 0 1 N N N 18.620 12.217 47.347 -15.840 -3.570 0.527 C26 H7T 16 H7T C28 C15 C 0 1 N N N 19.004 12.929 49.444 -14.793 -5.289 1.873 C28 H7T 17 H7T N N3 N 0 1 N N N 24.182 20.467 30.024 10.127 -4.267 -4.360 N H7T 18 H7T C C16 C 0 1 N N N 22.009 18.295 29.742 10.496 -5.127 -1.345 C H7T 19 H7T O O1 O 0 1 N N N 17.639 22.516 31.898 8.202 0.507 0.666 O H7T 20 H7T C1 C17 C 0 1 N N N 22.147 19.320 30.882 10.778 -3.740 -1.927 C1 H7T 21 H7T C11 C18 C 0 1 Y N N 13.838 21.197 33.522 2.689 3.481 0.996 C11 H7T 22 H7T C12 C19 C 0 1 Y N N 12.682 20.650 32.980 1.563 2.781 1.385 C12 H7T 23 H7T C14 C20 C 0 1 Y N N 12.396 19.286 34.927 0.373 3.642 -0.509 C14 H7T 24 H7T C16 C21 C 0 1 N N N 10.946 16.828 37.214 -3.069 3.183 -1.740 C16 H7T 25 H7T C18 C22 C 0 1 Y N N 12.598 15.497 38.708 -5.496 2.870 -0.991 C18 H7T 26 H7T C19 C23 C 0 1 N N N 13.364 14.059 40.630 -7.642 1.843 -0.194 C19 H7T 27 H7T C2 C24 C 0 1 N N N 22.699 18.656 32.157 12.278 -3.550 -2.160 C2 H7T 28 H7T C23 C25 C 0 1 N N N 16.478 13.542 44.607 -12.134 -0.333 0.261 C23 H7T 29 H7T C25 C26 C 0 1 N N N 17.863 14.379 46.605 -13.934 -2.063 0.361 C25 H7T 30 H7T C27 C27 C 0 1 N N N 18.927 11.728 48.735 -16.183 -4.801 1.404 C27 H7T 31 H7T C29 C28 C 0 1 N N N 17.780 13.681 48.961 -13.870 -4.064 1.738 C29 H7T 32 H7T C3 C29 C 0 1 N N N 22.936 20.547 30.475 10.003 -3.532 -3.212 C3 H7T 33 H7T C30 C30 C 0 1 N N N 16.500 13.292 43.104 -11.283 -1.183 -0.686 C30 H7T 34 H7T C31 C31 C 0 1 N N N 15.142 12.829 42.586 -10.509 -0.262 -1.635 C31 H7T 35 H7T C32 C32 C 0 1 Y N N 13.546 19.829 35.481 1.504 4.344 -0.899 C32 H7T 36 H7T C33 C33 C 0 1 Y N N 14.269 20.783 34.776 2.659 4.262 -0.147 C33 H7T 37 H7T C34 C34 C 0 1 N N N 15.539 21.482 35.162 4.019 4.901 -0.320 C34 H7T 38 H7T C35 C35 C 0 1 Y N N 18.566 20.347 31.856 9.824 -1.227 0.851 C35 H7T 39 H7T C36 C36 C 0 1 N N N 17.082 18.630 32.759 11.077 -1.612 2.836 C36 H7T 40 H7T C37 C37 C 0 1 N N N 16.371 17.962 31.607 11.233 -1.054 4.252 C37 H7T 41 H7T C38 C38 C 0 1 N N N 15.138 17.175 31.902 12.166 -1.802 5.207 C38 H7T 42 H7T C39 C39 C 0 1 N N N 15.035 18.476 31.180 12.587 -0.449 4.628 C39 H7T 43 H7T C40 C40 C 0 1 Y N N 19.609 19.473 31.593 10.506 -2.292 0.279 C40 H7T 44 H7T C41 C41 C 0 1 Y N N 20.821 19.989 31.163 10.239 -2.660 -1.017 C41 H7T 45 H7T C9 C42 C 0 1 N N N 16.271 23.783 34.123 5.559 3.022 -0.232 C9 H7T 46 H7T N2 N4 N 0 1 N N N 15.825 22.393 33.975 4.941 4.114 0.531 N2 H7T 47 H7T N4 N5 N 0 1 N N N 14.081 13.772 42.961 -9.742 0.703 -0.836 N4 H7T 48 H7T N5 N6 N 0 1 N N N 17.633 13.284 47.550 -14.703 -2.944 1.250 N5 H7T 49 H7T N6 N7 N 0 1 Y N N 11.109 14.850 40.208 -5.477 0.766 -0.602 N6 H7T 50 H7T N7 N8 N 0 1 Y N N 10.483 15.575 39.312 -4.293 1.081 -0.992 N7 H7T 51 H7T O1 O2 O 0 1 N N N 11.620 18.319 35.514 -0.765 3.721 -1.248 O1 H7T 52 H7T O2 O3 O 0 1 N N N 12.409 15.205 42.500 -7.843 0.178 -1.855 O2 H7T 53 H7T O3 O4 O 0 1 N N N 17.351 19.991 32.390 10.086 -0.858 2.134 O3 H7T 54 H7T H8 H1 H 0 1 N N N 20.074 23.305 31.062 7.859 -0.367 -1.768 H8 H7T 55 H7T H10 H2 H 0 1 N N N 18.717 23.995 32.893 6.468 0.462 -0.457 H10 H7T 56 H7T H9 H3 H 0 1 N N N 18.108 24.444 31.264 7.728 1.579 -1.035 H9 H7T 57 H7T H12 H4 H 0 1 N N N 16.786 25.538 33.007 6.102 1.903 1.527 H12 H7T 58 H7T H11 H5 H 0 1 N N N 15.794 24.340 32.109 7.361 3.020 0.949 H11 H7T 59 H7T H16 H6 H 0 1 N N N 15.160 21.930 31.991 4.056 4.271 2.452 H16 H7T 60 H7T H15 H7 H 0 1 N N N 14.205 23.201 32.828 4.417 2.601 1.921 H15 H7T 61 H7T H18 H8 H 0 1 N N N 11.060 19.278 33.249 -0.475 2.312 0.942 H18 H7T 62 H7T H20 H9 H 0 1 N N N 12.985 17.348 36.755 -2.167 3.308 0.212 H20 H7T 63 H7T H19 H10 H 0 1 N N N 12.034 18.660 37.529 -1.635 1.912 -0.756 H19 H7T 64 H7T H26 H11 H 0 1 N N N 13.244 14.764 44.612 -11.144 2.185 -0.328 H26 H7T 65 H7T H27 H12 H 0 1 N N N 13.759 13.069 44.913 -9.730 2.085 0.751 H27 H7T 66 H7T H28 H13 H 0 1 N N N 15.571 15.485 44.478 -10.522 -0.047 1.661 H28 H7T 67 H7T H29 H14 H 0 1 N N N 15.280 14.621 46.026 -11.829 1.156 1.788 H29 H7T 68 H7T H32 H15 H 0 1 N N N 18.578 13.256 44.932 -12.256 -1.928 1.704 H32 H7T 69 H7T H31 H16 H 0 1 N N N 18.098 14.946 44.557 -13.474 -0.647 1.918 H31 H7T 70 H7T H35 H17 H 0 1 N N N 18.198 11.408 46.733 -15.535 -3.882 -0.472 H35 H7T 71 H7T H36 H18 H 0 1 N N N 19.526 12.611 46.863 -16.687 -2.886 0.476 H36 H7T 72 H7T H39 H19 H 0 1 N N N 18.959 12.753 50.529 -14.838 -5.616 2.911 H39 H7T 73 H7T H40 H20 H 0 1 N N N 19.927 13.475 49.200 -14.442 -6.101 1.236 H40 H7T 74 H7T H7 H21 H 0 1 N N N 24.659 21.293 29.725 9.582 -4.054 -5.134 H7 H7T 75 H7T H6 H22 H 0 1 N N N 24.643 19.581 29.984 10.760 -5.001 -4.400 H6 H7T 76 H7T H1 H23 H 0 1 N N N 21.429 17.429 30.095 9.420 -5.263 -1.236 H1 H7T 77 H7T H2 H24 H 0 1 N N N 21.491 18.761 28.891 10.893 -5.890 -2.015 H2 H7T 78 H7T H H25 H 0 1 N N N 23.008 17.962 29.425 10.975 -5.216 -0.370 H H7T 79 H7T H17 H26 H 0 1 N N N 12.344 20.971 32.006 1.588 2.172 2.277 H17 H7T 80 H7T H22 H27 H 0 1 N N N 10.030 17.371 37.490 -3.326 4.241 -1.771 H22 H7T 81 H7T H21 H28 H 0 1 N N N 10.738 16.169 36.358 -2.793 2.846 -2.739 H21 H7T 82 H7T H23 H29 H 0 1 N N N 13.529 15.638 38.179 -5.830 3.893 -1.088 H23 H7T 83 H7T H25 H30 H 0 1 N N N 13.190 12.982 40.490 -7.734 1.587 0.861 H25 H7T 84 H7T H24 H31 H 0 1 N N N 14.379 14.313 40.291 -8.042 2.843 -0.362 H24 H7T 85 H7T H4 H32 H 0 1 N N N 22.788 19.409 32.954 12.639 -4.314 -2.850 H4 H7T 86 H7T H3 H33 H 0 1 N N N 22.014 17.858 32.481 12.457 -2.563 -2.586 H3 H7T 87 H7T H5 H34 H 0 1 N N N 23.690 18.226 31.947 12.808 -3.638 -1.212 H5 H7T 88 H7T H30 H35 H 0 1 N N N 16.260 12.586 45.105 -12.819 0.283 -0.322 H30 H7T 89 H7T H33 H36 H 0 1 N N N 18.854 14.803 46.825 -14.614 -1.386 -0.156 H33 H7T 90 H7T H34 H37 H 0 1 N N N 17.090 15.140 46.787 -13.396 -2.666 -0.370 H34 H7T 91 H7T H38 H38 H 0 1 N N N 18.123 11.085 49.121 -16.797 -4.509 2.256 H38 H7T 92 H7T H37 H39 H 0 1 N N N 19.881 11.181 48.766 -16.681 -5.568 0.812 H37 H7T 93 H7T H41 H40 H 0 1 N N N 17.933 14.767 49.045 -13.441 -3.813 2.709 H41 H7T 94 H7T H42 H41 H 0 1 N N N 16.892 13.390 49.541 -13.073 -4.276 1.025 H42 H7T 95 H7T H43 H42 H 0 1 N N N 17.248 12.517 42.883 -10.580 -1.781 -0.106 H43 H7T 96 H7T H44 H43 H 0 1 N N N 16.777 14.225 42.592 -11.930 -1.842 -1.265 H44 H7T 97 H7T H45 H44 H 0 1 N N N 14.912 11.842 43.014 -9.827 -0.855 -2.244 H45 H7T 98 H7T H46 H45 H 0 1 N N N 15.183 12.753 41.489 -11.209 0.270 -2.279 H46 H7T 99 H7T H47 H46 H 0 1 N N N 13.878 19.511 36.458 1.482 4.953 -1.790 H47 H7T 100 H7T H49 H47 H 0 1 N N N 16.356 20.760 35.308 4.331 4.846 -1.363 H49 H7T 101 H7T H48 H48 H 0 1 N N N 15.400 22.069 36.082 3.993 5.939 0.011 H48 H7T 102 H7T H51 H49 H 0 1 N N N 16.444 18.606 33.655 12.029 -1.540 2.310 H51 H7T 103 H7T H50 H50 H 0 1 N N N 18.027 18.107 32.967 10.769 -2.656 2.888 H50 H7T 104 H7T H52 H51 H 0 1 N N N 17.017 17.570 30.808 10.341 -0.595 4.678 H52 H7T 105 H7T H53 H52 H 0 1 N N N 14.774 17.090 32.937 11.889 -1.834 6.260 H53 H7T 106 H7T H54 H53 H 0 1 N N N 14.946 16.233 31.368 12.669 -2.691 4.826 H54 H7T 107 H7T H55 H54 H 0 1 N N N 14.596 19.351 31.682 13.367 -0.448 3.866 H55 H7T 108 H7T H56 H55 H 0 1 N N N 14.768 18.493 30.113 12.586 0.408 5.300 H56 H7T 109 H7T H57 H56 H 0 1 N N N 19.479 18.408 31.721 11.247 -2.830 0.853 H57 H7T 110 H7T H13 H57 H 0 1 N N N 17.160 23.793 34.771 6.050 3.429 -1.116 H13 H7T 111 H7T H14 H58 H 0 1 N N N 15.462 24.355 34.601 4.791 2.312 -0.537 H14 H7T 112 # loop_ _chem_comp_bond.comp_id _chem_comp_bond.atom_id_1 _chem_comp_bond.atom_id_2 _chem_comp_bond.value_order _chem_comp_bond.pdbx_aromatic_flag _chem_comp_bond.pdbx_stereo_config _chem_comp_bond.pdbx_ordinal H7T C C1 SING N N 1 H7T N C3 SING N N 2 H7T C3 N1 DOUB N N 3 H7T C3 C1 SING N N 4 H7T N1 C4 SING N N 5 H7T C1 C41 SING N N 6 H7T C1 C2 SING N N 7 H7T C4 C41 DOUB Y N 8 H7T C4 C5 SING Y N 9 H7T C41 C40 SING Y N 10 H7T C39 C37 SING N N 11 H7T C39 C38 SING N N 12 H7T C5 C6 DOUB Y N 13 H7T C40 C35 DOUB Y N 14 H7T C37 C38 SING N N 15 H7T C37 C36 SING N N 16 H7T C6 C35 SING Y N 17 H7T C6 O SING N N 18 H7T C35 O3 SING N N 19 H7T O C7 SING N N 20 H7T C7 C8 SING N N 21 H7T O3 C36 SING N N 22 H7T C8 C9 SING N N 23 H7T C10 C11 SING N N 24 H7T C10 N2 SING N N 25 H7T C12 C11 DOUB Y N 26 H7T C12 C13 SING Y N 27 H7T C11 C33 SING Y N 28 H7T C13 C14 DOUB Y N 29 H7T N2 C9 SING N N 30 H7T N2 C34 SING N N 31 H7T C33 C34 SING N N 32 H7T C33 C32 DOUB Y N 33 H7T C14 C32 SING Y N 34 H7T C14 O1 SING N N 35 H7T O1 C15 SING N N 36 H7T C15 C16 SING N N 37 H7T C16 C17 SING N N 38 H7T C17 C18 DOUB Y N 39 H7T C17 N7 SING Y N 40 H7T C18 N3 SING Y N 41 H7T N7 N6 DOUB Y N 42 H7T N3 N6 SING Y N 43 H7T N3 C19 SING N N 44 H7T C19 C20 SING N N 45 H7T C20 O2 DOUB N N 46 H7T C20 N4 SING N N 47 H7T C31 N4 SING N N 48 H7T C31 C30 SING N N 49 H7T N4 C21 SING N N 50 H7T C30 C23 SING N N 51 H7T C21 C22 SING N N 52 H7T C23 C22 SING N N 53 H7T C23 C24 SING N N 54 H7T C24 C25 SING N N 55 H7T C25 N5 SING N N 56 H7T C26 N5 SING N N 57 H7T C26 C27 SING N N 58 H7T N5 C29 SING N N 59 H7T C27 C28 SING N N 60 H7T C29 C28 SING N N 61 H7T C5 H8 SING N N 62 H7T C7 H10 SING N N 63 H7T C7 H9 SING N N 64 H7T C8 H12 SING N N 65 H7T C8 H11 SING N N 66 H7T C10 H16 SING N N 67 H7T C10 H15 SING N N 68 H7T C13 H18 SING N N 69 H7T C15 H20 SING N N 70 H7T C15 H19 SING N N 71 H7T C21 H26 SING N N 72 H7T C21 H27 SING N N 73 H7T C22 H28 SING N N 74 H7T C22 H29 SING N N 75 H7T C24 H32 SING N N 76 H7T C24 H31 SING N N 77 H7T C26 H35 SING N N 78 H7T C26 H36 SING N N 79 H7T C28 H39 SING N N 80 H7T C28 H40 SING N N 81 H7T N H7 SING N N 82 H7T N H6 SING N N 83 H7T C H1 SING N N 84 H7T C H2 SING N N 85 H7T C H SING N N 86 H7T C12 H17 SING N N 87 H7T C16 H22 SING N N 88 H7T C16 H21 SING N N 89 H7T C18 H23 SING N N 90 H7T C19 H25 SING N N 91 H7T C19 H24 SING N N 92 H7T C2 H4 SING N N 93 H7T C2 H3 SING N N 94 H7T C2 H5 SING N N 95 H7T C23 H30 SING N N 96 H7T C25 H33 SING N N 97 H7T C25 H34 SING N N 98 H7T C27 H38 SING N N 99 H7T C27 H37 SING N N 100 H7T C29 H41 SING N N 101 H7T C29 H42 SING N N 102 H7T C30 H43 SING N N 103 H7T C30 H44 SING N N 104 H7T C31 H45 SING N N 105 H7T C31 H46 SING N N 106 H7T C32 H47 SING N N 107 H7T C34 H49 SING N N 108 H7T C34 H48 SING N N 109 H7T C36 H51 SING N N 110 H7T C36 H50 SING N N 111 H7T C37 H52 SING N N 112 H7T C38 H53 SING N N 113 H7T C38 H54 SING N N 114 H7T C39 H55 SING N N 115 H7T C39 H56 SING N N 116 H7T C40 H57 SING N N 117 H7T C9 H13 SING N N 118 H7T C9 H14 SING N N 119 # loop_ _pdbx_chem_comp_descriptor.comp_id _pdbx_chem_comp_descriptor.type _pdbx_chem_comp_descriptor.program _pdbx_chem_comp_descriptor.program_version _pdbx_chem_comp_descriptor.descriptor H7T InChI InChI 1.03 ;InChI=1S/C42H58N8O4/c1-42(2)36-23-38(54-29-31-6-7-31)39(24-37(36)44-41(42)43)53-20-5-16-48-25-32-8-9-35(22-33(32)26-48)52-21-13-34-27-50(46-45-34)28-40(51)49-18-11-30(12-19-49)10-17-47-14-3-4-15-47/h8-9,22-24,27,30-31H,3-7,10-21,25-26,28-29H2,1-2H3,(H2,43,44) ; H7T InChIKey InChI 1.03 XPEJZXWPKDAYFX-UHFFFAOYSA-N H7T SMILES_CANONICAL CACTVS 3.385 "CC1(C)C(=Nc2cc(OCCCN3Cc4ccc(OCCc5cn(CC(=O)N6CCC(CCN7CCCC7)CC6)nn5)cc4C3)c(OCC8CC8)cc12)N" H7T SMILES CACTVS 3.385 "CC1(C)C(=Nc2cc(OCCCN3Cc4ccc(OCCc5cn(CC(=O)N6CCC(CCN7CCCC7)CC6)nn5)cc4C3)c(OCC8CC8)cc12)N" H7T SMILES_CANONICAL "OpenEye OEToolkits" 2.0.6 "CC1(c2cc(c(cc2N=C1N)OCCCN3Cc4ccc(cc4C3)OCCc5cn(nn5)CC(=O)N6CCC(CC6)CCN7CCCC7)OCC8CC8)C" H7T SMILES "OpenEye OEToolkits" 2.0.6 "CC1(c2cc(c(cc2N=C1N)OCCCN3Cc4ccc(cc4C3)OCCc5cn(nn5)CC(=O)N6CCC(CC6)CCN7CCCC7)OCC8CC8)C" # loop_ _pdbx_chem_comp_identifier.comp_id _pdbx_chem_comp_identifier.type _pdbx_chem_comp_identifier.program _pdbx_chem_comp_identifier.program_version _pdbx_chem_comp_identifier.identifier H7T "SYSTEMATIC NAME" "OpenEye OEToolkits" 2.0.6 "2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone" # loop_ _pdbx_chem_comp_audit.comp_id _pdbx_chem_comp_audit.action_type _pdbx_chem_comp_audit.date _pdbx_chem_comp_audit.processing_site H7T "Create component" 2018-11-20 EBI H7T "Initial release" 2018-12-05 RCSB #