1 R8E 3-{5-[(6-amino-1h-pyrazolo[3,4-B]pyridin-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile 1.000 2 R8D 3-chloro-5-[2-chloro-5-(1h-pyrazolo[3,4-B]pyridin-3-ylmethoxy)phenoxy]benzonitrile 0.966 3 M22 3-chloro-5-[2-chloro-5-(1h-indazol-3-ylmethoxy)phenoxy]benzonitrile 0.900