1 954 5-{(2e,4ar,7ar)-6-[5-fluoro-4-methyl-6-(methylsulfanyl)pyrimidin-2-yl]-2-imino-3-methyl-4-oxooctahydro-7ah-pyrrolo[3,4-D]pyrimidin-7a-yl}thiophene-2-carbonitrile 1.000 2 60S 5-{(2e,4ar,7ar)-6-[5-fluoro-4-methyl-6-(methylamino)pyrimidin-2-yl]-2-imino-3-methyl-4-oxooctahydro-7ah-pyrrolo[3,4-D]pyrimidin-7a-yl}thiophene-2-carbonitrile 0.871 3 60V 5-[(2e,4ar,7ar)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-2-imino-3-methyl-4-oxooctahydro-7ah-pyrrolo[3,4-D]pyrimidin-7a-yl]thiophene-2-carbonitrile 0.871 4 60U 5-[(2e,4ar,7ar)-6-(4-ethoxy-5-fluoro-6-methylpyrimidin-2-yl)-2-imino-3-methyl-4-oxooctahydro-7ah-pyrrolo[3,4-D]pyrimidin-7a-yl]thiophene-2-carbonitrile 0.844