1 8B0 (4~{S})-6-azanyl-4-[3-(2-cyanophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-C]pyrazole-5-carbonitrile 1.000 2 8A0 (4~{S})-6-azanyl-3-methyl-4-[3-(2-methylphenyl)-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2~{H}-pyrano[2,3-C]pyrazole-5-carbonitrile 0.971 3 8AU (4~{S})-6-azanyl-4-[3-(2-chlorophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-C]pyrazole-5- carbonitrile 0.914 4 8B3 (4~{S})-6-azanyl-4-[3-(2-fluorophenyl)-5-(trifluoromethyl)phenyl]-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-C]pyrazole-5- carbonitrile 0.914 5 G57 2-[3-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-C]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]phenyl]ethanoic acid 0.842 6 5M5 (4r)-6-azanyl-4-[3-(hydroxymethyl)-5-phenyl-phenyl]-3-methyl-4-propan-2-yl-1h-pyrano[2,3-C]pyrazole-5-carbonitrile 0.829 7 GCF 3-[3-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-C]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]phenyl]propanoic acid 0.821 8 8A3 4-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-C]pyrazol-4-yl]-5-(trifluoromethyl)phenyl]-~{N}-methyl-~{N}-[2,2,2-tris(fluoranyl)ethyl]benzenesulfonamide 0.727 9 8AO (4~{S})-6-azanyl-3-methyl-4-[3-[4-(phenylmethyl)sulfonylphenyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-2~{H}-pyrano[2 ,3-C]pyrazole-5-carbonitrile 0.727 10 G6F 3-[3-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-C]pyrazol-4-yl]-5-fluoranyl-phenyl]phenyl]propanoic acid 0.700